PAF-Antagonist Administration after Hemorrhage-Resuscitation Prevents Splenocyte Immunodepression

A number of studies have suggested that the inflammatory and chemotactic autocoid platelet activating factor (PAF), together with various cytokines, plays an important role in the pathophysiology of trauma, sepsis, and shock. However, little is known about PAF's contribution to the immunosuppre...

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Veröffentlicht in:	The Journal of surgical research 1995-09, Vol.59 (3), p.366-370
Hauptverfasser:	Zellweger, René, Ayala, Alfred, Schmand, Jochen F., Morrison, Mary H., Chaudry, Irshad H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Hemorrhage - drug therapy Hemorrhage - immunology Hemorrhage - physiopathology Immune Tolerance - drug effects Immunomodulators Interleukin-2 - metabolism Interleukin-3 - metabolism Lymphokines - drug effects Lymphokines - metabolism Male Medical sciences Mice Mice, Inbred C3H Pharmacology. Drug treatments Phenanthridines - pharmacology Platelet Activating Factor - antagonists & inhibitors Spleen - cytology Spleen - drug effects Spleen - immunology Triazines - pharmacology
Online-Zugang:	Volltext
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