Unidirectional potentiation of binding between two anti-FBP MAbs: Evaluation of involved mechanisms

The monoclonal antibody MOv19 directed to a folate binding protein shows temperature‐dependent potentiation of binding of the noncompeting monoclonal antibody MOv18 to the relevant antigen, but the mechanism involved in this phinomenon had remained unclear. Use of chimeric versions of both monoclona...

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Veröffentlicht in:	Journal of cellular biochemistry 1995-05, Vol.58 (1), p.47-55
Hauptverfasser:	Casaline, Patrizia, Mezzanzanica, Delia, Valota, Olga, Adobati, Elena, Tomassetti, Antonella, Colnaghi, Maria I., Canevari, Silvana
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antibody Affinity Antigen-Antibody Reactions Binding Sites, Antibody Binding, Competitive Carcinoma Carrier Proteins - immunology conformational change Female folate binding protien Folate Receptors, GPI-Anchored human ovary carcinoma human overy cancinoma Humans Immunoblotting Immunoglobulin Fab Fragments - immunology Kinetics monoclonal antibodies Ovarian Neoplasms potentiation Protein Conformation Receptors, Cell Surface - immunology Recombinant Fusion Proteins - immunology Time Factors Tumor Cells, Cultured
Online-Zugang:	Volltext
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