Müllerian inhibiting substance blocks autophosphorylation of the EGF receptor by inhibiting tyrosine kinase

The fetal regressor Mullerian inhibiting substance (MIS), in concentrations as low as picomolar, inhibited the growth of A-431 cells and the autophosphorylation of its epidermal growth factor (EGF) receptor. The inhibition of membrane phosphorylation was due neither to the reduction of the total num...

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Veröffentlicht in:	Molecular and cellular endocrinology 1987, Vol.49 (1), p.75-86
Hauptverfasser:	Coughlin, John P., Donahoe, Patricia K., Budzik, Gerald P., MacLaughlin, David T.
Format:	Artikel
Sprache:	eng
Schlagworte:	A-431 cell Animals Anti-Mullerian Hormone Apud cells. Peptide and protein hormones. Growth factors Biological and medical sciences Cattle Cell Division - drug effects Cell Line Cell Membrane - enzymology Epidermal Growth Factor - pharmacology ErbB Receptors - metabolism Female Fetal inhibitor/regressor Fundamental and applied biological sciences. Psychology Glycoproteins Growth Inhibitors Humans Male Mechanism of action Mullerian inhibiting substance Phosphoric Monoester Hydrolases - metabolism Phosphorylation Protein-Tyrosine Kinases - antagonists & inhibitors Testicular Hormones - pharmacology Vertebrates: endocrinology Vulvar Neoplasms
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