Body weight and mortality among women
Background. The relation between body weight and overall mortality remains controversial despite considerable investigation. Methods. We examined the association between body-mass index (defined as the weight in kilograms divided by the square of the height in meters) and both overall mortality and...
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| Veröffentlicht in: | The New England journal of medicine 1995-09, Vol.333 (11), p.677-685 |
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| creator | Manson, J.E. (Harvard Medical School, Boston, MA.) Willett, W.C Stampfer, M.J Colditz, G.A Hunter, D.J Hankinson, S.E Hennekens, C.H Speizer, F.E |
| description | Background. The relation between body weight and overall mortality remains controversial despite considerable investigation. Methods. We examined the association between body-mass index (defined as the weight in kilograms divided by the square of the height in meters) and both overall mortality and mortality from specific causes in a cohort of 115,195 U.S. women enrolled in the prospective Nurses' Health Study. These women were 30 to 55 years of age and free of known cardiovascular disease and cancer in 1976. During 16 years of follow-up, we documented 4726 deaths, of which 881 were from cardiovascular disease, 2586 from cancer, and 1259 from other causes. Results. In analyses adjusted only for age, we observed a J-shaped relation between body-mass index and overall mortality. When women who had never smoked were examined separately, no increase in risk was observed among the leaner women, and a more direct relation between weight and mortality emerged (P for trend 0.001). In multivariate analyses of women who had never smoked and had recently had stable weight, in which the first four years of follow-up were excluded, the relative risks of death from all causes for increasing categories of body-mass index were as follows: body-mass index 19.0 (the reference category), relative risk |
| doi_str_mv | 10.1056/NEJM199509143331101 |
| format | Article |
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(Harvard Medical School, Boston, MA.) ; Willett, W.C ; Stampfer, M.J ; Colditz, G.A ; Hunter, D.J ; Hankinson, S.E ; Hennekens, C.H ; Speizer, F.E</creator><creatorcontrib>Manson, J.E. (Harvard Medical School, Boston, MA.) ; Willett, W.C ; Stampfer, M.J ; Colditz, G.A ; Hunter, D.J ; Hankinson, S.E ; Hennekens, C.H ; Speizer, F.E</creatorcontrib><description>Background. The relation between body weight and overall mortality remains controversial despite considerable investigation. Methods. We examined the association between body-mass index (defined as the weight in kilograms divided by the square of the height in meters) and both overall mortality and mortality from specific causes in a cohort of 115,195 U.S. women enrolled in the prospective Nurses' Health Study. These women were 30 to 55 years of age and free of known cardiovascular disease and cancer in 1976. During 16 years of follow-up, we documented 4726 deaths, of which 881 were from cardiovascular disease, 2586 from cancer, and 1259 from other causes. Results. In analyses adjusted only for age, we observed a J-shaped relation between body-mass index and overall mortality. When women who had never smoked were examined separately, no increase in risk was observed among the leaner women, and a more direct relation between weight and mortality emerged (P for trend 0.001). In multivariate analyses of women who had never smoked and had recently had stable weight, in which the first four years of follow-up were excluded, the relative risks of death from all causes for increasing categories of body-mass index were as follows: body-mass index 19.0 (the reference category), relative risk</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199509143331101</identifier><identifier>PMID: 7637744</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adult ; ADULTE ; ADULTOS ; Age ; Biological and medical sciences ; Body Constitution ; Body Mass Index ; Body Weight ; CARCINOMAS ; CARCINOME ; CARDIOPATHIE ; Cardiovascular Diseases - mortality ; Cause of Death ; ENFERMEDADES CARDIACAS ; ENFERMEDADES CARDIOVASCULARES ; ETATS UNIS ; EUA ; Family medical history ; Female ; FEMME ; GAIN DE POIDS ; GANANCIA DE PESO ; General aspects ; Humans ; MALADIE CARDIOVASCULAIRE ; Medical sciences ; Middle Aged ; MORTALIDAD ; MORTALITE ; Mortality ; MUJERES ; Multivariate Analysis ; Neoplasms - mortality ; Nurses ; Obesity ; PERDIDA DE PESO ; PERTE DE POIDS ; PESO ; Planification. Prevention (methods). Intervention. Evaluation ; POIDS ; Prospective Studies ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Reference Values ; RIESGO ; Risk Factors ; RISQUE ; Smoking ; TABAC ; TABACO ; United States - epidemiology ; Weight control ; Weight Gain ; Womens health</subject><ispartof>The New England journal of medicine, 1995-09, Vol.333 (11), p.677-685</ispartof><rights>Copyright © 1995 Massachusetts Medical Society. All rights reserved.</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c650t-31ec96e826877a2cc9efcd33bda27e18fd5093f3015c010c989b6348bb33a8733</citedby><cites>FETCH-LOGICAL-c650t-31ec96e826877a2cc9efcd33bda27e18fd5093f3015c010c989b6348bb33a8733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199509143331101$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199509143331101$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3663417$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7637744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manson, J.E. (Harvard Medical School, Boston, MA.)</creatorcontrib><creatorcontrib>Willett, W.C</creatorcontrib><creatorcontrib>Stampfer, M.J</creatorcontrib><creatorcontrib>Colditz, G.A</creatorcontrib><creatorcontrib>Hunter, D.J</creatorcontrib><creatorcontrib>Hankinson, S.E</creatorcontrib><creatorcontrib>Hennekens, C.H</creatorcontrib><creatorcontrib>Speizer, F.E</creatorcontrib><title>Body weight and mortality among women</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Background. The relation between body weight and overall mortality remains controversial despite considerable investigation. Methods. We examined the association between body-mass index (defined as the weight in kilograms divided by the square of the height in meters) and both overall mortality and mortality from specific causes in a cohort of 115,195 U.S. women enrolled in the prospective Nurses' Health Study. These women were 30 to 55 years of age and free of known cardiovascular disease and cancer in 1976. During 16 years of follow-up, we documented 4726 deaths, of which 881 were from cardiovascular disease, 2586 from cancer, and 1259 from other causes. Results. In analyses adjusted only for age, we observed a J-shaped relation between body-mass index and overall mortality. When women who had never smoked were examined separately, no increase in risk was observed among the leaner women, and a more direct relation between weight and mortality emerged (P for trend 0.001). In multivariate analyses of women who had never smoked and had recently had stable weight, in which the first four years of follow-up were excluded, the relative risks of death from all causes for increasing categories of body-mass index were as follows: body-mass index 19.0 (the reference category), relative risk</description><subject>Adult</subject><subject>ADULTE</subject><subject>ADULTOS</subject><subject>Age</subject><subject>Biological and medical sciences</subject><subject>Body Constitution</subject><subject>Body Mass Index</subject><subject>Body Weight</subject><subject>CARCINOMAS</subject><subject>CARCINOME</subject><subject>CARDIOPATHIE</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Cause of Death</subject><subject>ENFERMEDADES CARDIACAS</subject><subject>ENFERMEDADES CARDIOVASCULARES</subject><subject>ETATS UNIS</subject><subject>EUA</subject><subject>Family medical history</subject><subject>Female</subject><subject>FEMME</subject><subject>GAIN DE POIDS</subject><subject>GANANCIA DE PESO</subject><subject>General aspects</subject><subject>Humans</subject><subject>MALADIE CARDIOVASCULAIRE</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>MORTALIDAD</subject><subject>MORTALITE</subject><subject>Mortality</subject><subject>MUJERES</subject><subject>Multivariate Analysis</subject><subject>Neoplasms - mortality</subject><subject>Nurses</subject><subject>Obesity</subject><subject>PERDIDA DE PESO</subject><subject>PERTE DE POIDS</subject><subject>PESO</subject><subject>Planification. Prevention (methods). Intervention. Evaluation</subject><subject>POIDS</subject><subject>Prospective Studies</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Reference Values</subject><subject>RIESGO</subject><subject>Risk Factors</subject><subject>RISQUE</subject><subject>Smoking</subject><subject>TABAC</subject><subject>TABACO</subject><subject>United States - epidemiology</subject><subject>Weight control</subject><subject>Weight Gain</subject><subject>Womens health</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkEtP3DAUha2qiA60f4CqUlRRNijgm-v4sQREgYrHAlhbjuNMM4pjameE5t_XoxmxqCrhzV2c7x7fcwj5CvQEaM1P7y9_3YFSNVXAEBGAwgcygxqxZIzyj2RGaSVLJhR-InspLWh-wNQu2RUchWBsRn6ch3ZVvLp-_nsqzNgWPsTJDP20KowP47x4Dd6Nn8lOZ4bkvmznPnn-efl0cV3ePlzdXJzdlpbXdCoRnFXcyYpLIUxlrXKdbRGb1lTCgezafCt2SKG2FKhVUjUcmWwaRCMF4j452vi-xPBn6dKkfZ-sGwYzurBMen0zVUq8CwJXvJZKZfD7P-AiLOOYQ-iqQiU5YJUh3EA2hpSi6_RL7L2JKw1Ur6vW_6k6b33bWi8b79q3nW23WT_c6iZZM3TRjLZPbxjyHB3WUY43mPdJj27h3_n0YEN3Jmgzj9nw-VGJrFQM_wJMmpcF</recordid><startdate>19950914</startdate><enddate>19950914</enddate><creator>Manson, J.E. 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(Harvard Medical School, Boston, MA.) ; Willett, W.C ; Stampfer, M.J ; Colditz, G.A ; Hunter, D.J ; Hankinson, S.E ; Hennekens, C.H ; Speizer, F.E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c650t-31ec96e826877a2cc9efcd33bda27e18fd5093f3015c010c989b6348bb33a8733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>ADULTE</topic><topic>ADULTOS</topic><topic>Age</topic><topic>Biological and medical sciences</topic><topic>Body Constitution</topic><topic>Body Mass Index</topic><topic>Body Weight</topic><topic>CARCINOMAS</topic><topic>CARCINOME</topic><topic>CARDIOPATHIE</topic><topic>Cardiovascular Diseases - mortality</topic><topic>Cause of Death</topic><topic>ENFERMEDADES CARDIACAS</topic><topic>ENFERMEDADES CARDIOVASCULARES</topic><topic>ETATS UNIS</topic><topic>EUA</topic><topic>Family medical history</topic><topic>Female</topic><topic>FEMME</topic><topic>GAIN DE POIDS</topic><topic>GANANCIA DE PESO</topic><topic>General aspects</topic><topic>Humans</topic><topic>MALADIE CARDIOVASCULAIRE</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>MORTALIDAD</topic><topic>MORTALITE</topic><topic>Mortality</topic><topic>MUJERES</topic><topic>Multivariate Analysis</topic><topic>Neoplasms - mortality</topic><topic>Nurses</topic><topic>Obesity</topic><topic>PERDIDA DE PESO</topic><topic>PERTE DE POIDS</topic><topic>PESO</topic><topic>Planification. Prevention (methods). Intervention. Evaluation</topic><topic>POIDS</topic><topic>Prospective Studies</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Reference Values</topic><topic>RIESGO</topic><topic>Risk Factors</topic><topic>RISQUE</topic><topic>Smoking</topic><topic>TABAC</topic><topic>TABACO</topic><topic>United States - epidemiology</topic><topic>Weight control</topic><topic>Weight Gain</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manson, J.E. 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(Harvard Medical School, Boston, MA.)</au><au>Willett, W.C</au><au>Stampfer, M.J</au><au>Colditz, G.A</au><au>Hunter, D.J</au><au>Hankinson, S.E</au><au>Hennekens, C.H</au><au>Speizer, F.E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body weight and mortality among women</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1995-09-14</date><risdate>1995</risdate><volume>333</volume><issue>11</issue><spage>677</spage><epage>685</epage><pages>677-685</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Background. The relation between body weight and overall mortality remains controversial despite considerable investigation. Methods. We examined the association between body-mass index (defined as the weight in kilograms divided by the square of the height in meters) and both overall mortality and mortality from specific causes in a cohort of 115,195 U.S. women enrolled in the prospective Nurses' Health Study. These women were 30 to 55 years of age and free of known cardiovascular disease and cancer in 1976. During 16 years of follow-up, we documented 4726 deaths, of which 881 were from cardiovascular disease, 2586 from cancer, and 1259 from other causes. Results. In analyses adjusted only for age, we observed a J-shaped relation between body-mass index and overall mortality. When women who had never smoked were examined separately, no increase in risk was observed among the leaner women, and a more direct relation between weight and mortality emerged (P for trend 0.001). In multivariate analyses of women who had never smoked and had recently had stable weight, in which the first four years of follow-up were excluded, the relative risks of death from all causes for increasing categories of body-mass index were as follows: body-mass index 19.0 (the reference category), relative risk</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>7637744</pmid><doi>10.1056/NEJM199509143331101</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The New England journal of medicine, 1995-09, Vol.333 (11), p.677-685 |
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| language | eng |
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| subjects | Adult ADULTE ADULTOS Age Biological and medical sciences Body Constitution Body Mass Index Body Weight CARCINOMAS CARCINOME CARDIOPATHIE Cardiovascular Diseases - mortality Cause of Death ENFERMEDADES CARDIACAS ENFERMEDADES CARDIOVASCULARES ETATS UNIS EUA Family medical history Female FEMME GAIN DE POIDS GANANCIA DE PESO General aspects Humans MALADIE CARDIOVASCULAIRE Medical sciences Middle Aged MORTALIDAD MORTALITE Mortality MUJERES Multivariate Analysis Neoplasms - mortality Nurses Obesity PERDIDA DE PESO PERTE DE POIDS PESO Planification. Prevention (methods). Intervention. Evaluation POIDS Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine Reference Values RIESGO Risk Factors RISQUE Smoking TABAC TABACO United States - epidemiology Weight control Weight Gain Womens health |
| title | Body weight and mortality among women |
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