Two polyamine analogs (BE-4-4-4 and BE-4-4-4-4) directly affect growth, survival, and cell cycle progression in two human brain tumor cell lines
1,14-Bis-(ethyl)-amino-5,10-diazatetradecane N1,N11-bis(ethyl)norspermine (BE-4-4-4) and 1,19-bis-(ethylamino)-5,10,15 triazanonadecane (BE-4-4-4-4) are two relatively new polyamine analogs synthesized for use as antineoplastic agents. In human brain tumor cell lines U-251 MG and SF-767, both agents...
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| Veröffentlicht in: | Cancer chemotherapy and pharmacology 1995, Vol.36 (5), p.411-417 |
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| container_issue | 5 |
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| container_title | Cancer chemotherapy and pharmacology |
| container_volume | 36 |
| creator | BERGERON, C. J BASU, H. S MARTON, L. J DEEN, D. F PELLARIN, M FEUERSTEIN, B. G |
| description | 1,14-Bis-(ethyl)-amino-5,10-diazatetradecane N1,N11-bis(ethyl)norspermine (BE-4-4-4) and 1,19-bis-(ethylamino)-5,10,15 triazanonadecane (BE-4-4-4-4) are two relatively new polyamine analogs synthesized for use as antineoplastic agents. In human brain tumor cell lines U-251 MG and SF-767, both agents inhibited cell growth, were cytotoxic, induced a variable G1/S block, and depleted intracellular polyamines. Since intracellular polyamine depletion did not always correlate with growth inhibition, cell survival, or cell cycle progression, it cannot completely explain the effects of these agents on growth, survival, and cell cycle progression in U-251 MG and SF-767 cells. |
| doi_str_mv | 10.1007/BF00686190 |
| format | Article |
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Since intracellular polyamine depletion did not always correlate with growth inhibition, cell survival, or cell cycle progression, it cannot completely explain the effects of these agents on growth, survival, and cell cycle progression in U-251 MG and SF-767 cells.</description><identifier>ISSN: 0344-5704</identifier><identifier>EISSN: 1432-0843</identifier><identifier>DOI: 10.1007/BF00686190</identifier><identifier>PMID: 7634383</identifier><identifier>CODEN: CCPHDZ</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Antineoplastic agents ; Antineoplastic Agents - pharmacology ; Biological and medical sciences ; Brain Neoplasms - drug therapy ; Flow Cytometry ; General aspects ; Growth Inhibitors - pharmacology ; Humans ; Medical sciences ; Pharmacology. 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J</creatorcontrib><creatorcontrib>BASU, H. S</creatorcontrib><creatorcontrib>MARTON, L. J</creatorcontrib><creatorcontrib>DEEN, D. F</creatorcontrib><creatorcontrib>PELLARIN, M</creatorcontrib><creatorcontrib>FEUERSTEIN, B. G</creatorcontrib><title>Two polyamine analogs (BE-4-4-4 and BE-4-4-4-4) directly affect growth, survival, and cell cycle progression in two human brain tumor cell lines</title><title>Cancer chemotherapy and pharmacology</title><addtitle>Cancer Chemother Pharmacol</addtitle><description>1,14-Bis-(ethyl)-amino-5,10-diazatetradecane N1,N11-bis(ethyl)norspermine (BE-4-4-4) and 1,19-bis-(ethylamino)-5,10,15 triazanonadecane (BE-4-4-4-4) are two relatively new polyamine analogs synthesized for use as antineoplastic agents. In human brain tumor cell lines U-251 MG and SF-767, both agents inhibited cell growth, were cytotoxic, induced a variable G1/S block, and depleted intracellular polyamines. Since intracellular polyamine depletion did not always correlate with growth inhibition, cell survival, or cell cycle progression, it cannot completely explain the effects of these agents on growth, survival, and cell cycle progression in U-251 MG and SF-767 cells.</description><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - drug therapy</subject><subject>Flow Cytometry</subject><subject>General aspects</subject><subject>Growth Inhibitors - pharmacology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacology. 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G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c226t-5613ee7cb1e1512574045e531ceff57b190bf130624b21caa8293b41484d00a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Brain Neoplasms - drug therapy</topic><topic>Flow Cytometry</topic><topic>General aspects</topic><topic>Growth Inhibitors - pharmacology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Spermine - analogs & derivatives</topic><topic>Spermine - pharmacology</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BERGERON, C. J</creatorcontrib><creatorcontrib>BASU, H. S</creatorcontrib><creatorcontrib>MARTON, L. 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G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two polyamine analogs (BE-4-4-4 and BE-4-4-4-4) directly affect growth, survival, and cell cycle progression in two human brain tumor cell lines</atitle><jtitle>Cancer chemotherapy and pharmacology</jtitle><addtitle>Cancer Chemother Pharmacol</addtitle><date>1995</date><risdate>1995</risdate><volume>36</volume><issue>5</issue><spage>411</spage><epage>417</epage><pages>411-417</pages><issn>0344-5704</issn><eissn>1432-0843</eissn><coden>CCPHDZ</coden><abstract>1,14-Bis-(ethyl)-amino-5,10-diazatetradecane N1,N11-bis(ethyl)norspermine (BE-4-4-4) and 1,19-bis-(ethylamino)-5,10,15 triazanonadecane (BE-4-4-4-4) are two relatively new polyamine analogs synthesized for use as antineoplastic agents. In human brain tumor cell lines U-251 MG and SF-767, both agents inhibited cell growth, were cytotoxic, induced a variable G1/S block, and depleted intracellular polyamines. Since intracellular polyamine depletion did not always correlate with growth inhibition, cell survival, or cell cycle progression, it cannot completely explain the effects of these agents on growth, survival, and cell cycle progression in U-251 MG and SF-767 cells.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>7634383</pmid><doi>10.1007/BF00686190</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0344-5704 |
| ispartof | Cancer chemotherapy and pharmacology, 1995, Vol.36 (5), p.411-417 |
| issn | 0344-5704 1432-0843 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Brain Neoplasms - drug therapy Flow Cytometry General aspects Growth Inhibitors - pharmacology Humans Medical sciences Pharmacology. Drug treatments Spermine - analogs & derivatives Spermine - pharmacology Tumor Cells, Cultured |
| title | Two polyamine analogs (BE-4-4-4 and BE-4-4-4-4) directly affect growth, survival, and cell cycle progression in two human brain tumor cell lines |
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