Evaluation of the safety, immunogenicity, and efficacy in healthy adults of four doses of live oral hybrid Escherichia coli-Shigella flexneri 2a vaccine strain EcSf2a-2

In previous trials, live invasive Escherichia coli-Shigella flexneri 2a hybrid vaccine candidate EcSf2a-2, administered to adult volunteers as 3 doses of ca. 2×10 9 colony forming units (c.f.u.) spaced over one week, induced fever and/or diarrhea in 11% of subjects and provided only limited protecti...

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Veröffentlicht in:	Vaccine 1995, Vol.13 (5), p.495-502
Hauptverfasser:	Kotloff, Karen L., Losonsky, Genevieve A., Nataro, James P., Wasserman, Steven S., Hale, Thomas L., Taylor, David N., Newland, John W., Sadoff, Jeral C., Formal, Samuel B., Levine, Myron M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Antibodies, Bacterial - biosynthesis Antibodies, Bacterial - blood Bacterial Vaccines - adverse effects Bacterial Vaccines - immunology Bacterial Vaccines - therapeutic use Bacteriology Biological and medical sciences Drug Administration Schedule Dysentery, Bacillary - immunology Dysentery, Bacillary - prevention & control Escherichia coli Escherichia coli - immunology Evaluation Studies as Topic Fundamental and applied biological sciences. Psychology Humans Immunization Schedule Immunoglobulin A - biosynthesis Immunoglobulin A - blood Immunoglobulin G - biosynthesis Immunoglobulin G - blood Microbiology mucosal immunity Phase I study Shigella flexneri Shigella flexneri - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
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