Relationship between multidrug resistant gene expression and multidrug resistant-reversing effect of MS-209 in various tumor cells

MS-209 is a novel quinoline compound which can overcome multidrug resistance (MDR) both in vitro and in vivo, while having a low level of side effects, and is now being evaluated in a clinical phase II study. Reverse transcription-polymerase chain reaction (RT-PCR) was used to quantitate the express...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 1995, Vol.36 (5), p.361-367
Hauptverfasser:	BABA, M, NAKANISHI, O, SATO, W, SAITO, A, MIYAMA, Y, YANO, O, SHIMADA, S, FUKAZAWA, N, NAITO, M, TSURUO, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Base Sequence Biological and medical sciences Blotting, Western Cell Line Drug Resistance, Multiple - genetics Gene Expression - drug effects Gene Expression - genetics General aspects Humans Medical sciences Mice Molecular Sequence Data Pharmacology. Drug treatments Polymerase Chain Reaction - methods Quinolines - chemistry Quinolines - pharmacology RNA, Messenger - drug effects RNA, Messenger - genetics RNA, Neoplasm - drug effects RNA, Neoplasm - genetics Transcription, Genetic
Online-Zugang:	Volltext
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