Expression of p53 oncoprotein in non-small-cell lung cancer: a favorable prognostic factor
Mutation of the p53 gene is one of the most common genetic abnormalities found in lung cancer. The purpose of this study was to evaluate the prognostic value of p53 oncoprotein expression in patients with non-small-cell lung cancer (NSCLC). We studied 156 resected primary NSCLCs by the immunohistoch...
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| Veröffentlicht in: | Journal of clinical oncology 1995-08, Vol.13 (8), p.1893-1903 |
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| creator | JIN SOO LEE YOON, A KALAPURAKAL, S. K RO, J. Y LEE, J. J TU, N HITTELMAN, W. N HONG, W. K |
| description | Mutation of the p53 gene is one of the most common genetic abnormalities found in lung cancer. The purpose of this study was to evaluate the prognostic value of p53 oncoprotein expression in patients with non-small-cell lung cancer (NSCLC).
We studied 156 resected primary NSCLCs by the immunohistochemical staining technique, using the p53 antibody DO7. There were 81 adenocarcinomas, 16 large-cell carcinomas, and 59 squamous cell carcinomas; stages were I in 67, II in 30, and III in 59 cases. For each tumor, the percentage of p53 positivity was calculated by scoring a minimum of 1,000 cells on an arbitrary intensity scale of 0 to 3+.
Overall, 103 (66%) tumors expressed p53 in more than 0.1% of cells, and squamous cell carcinomas tended to express more p53 than adenocarcinomas. Since 50% positivity marked the most distinct change in overall survival duration (P = .0008), we divided the cases into three groups, as follows: p53-negative (< or = 0.1%, n = 53), low p53 (0.1% to 50%, n = 54), and high p53 (> 50%, n = 49). Overall, patients in the high-p53 group survived longer than those in the low or negative groups, with respective median survival durations of more than 65, 26, and 33 months (P = .002). The survival difference among the three groups was statistically significant for non-squamous cell (P = .008), but not for squamous cell (P = .17) carcinomas. Among lymph node-negative patients, the survival difference between groups was not statistically significant. However, among lymph node-positive patients (n = 78), more than 65% of the high-p53 group survived for more than 70 months, while the median survival durations for the low and negative groups were 21 and 18 months, respectively (P = .001). A Cox regression analysis with multiple covariates showed that p53 positivity in more than 50% of tumor cells was an independent prognostic factor for better outcome.
These results suggest that high expression of the p53 oncoprotein is a favorable prognostic factor in a subset of patients with NSCLC. |
| doi_str_mv | 10.1200/jco.1995.13.8.1893 |
| format | Article |
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We studied 156 resected primary NSCLCs by the immunohistochemical staining technique, using the p53 antibody DO7. There were 81 adenocarcinomas, 16 large-cell carcinomas, and 59 squamous cell carcinomas; stages were I in 67, II in 30, and III in 59 cases. For each tumor, the percentage of p53 positivity was calculated by scoring a minimum of 1,000 cells on an arbitrary intensity scale of 0 to 3+.
Overall, 103 (66%) tumors expressed p53 in more than 0.1% of cells, and squamous cell carcinomas tended to express more p53 than adenocarcinomas. Since 50% positivity marked the most distinct change in overall survival duration (P = .0008), we divided the cases into three groups, as follows: p53-negative (< or = 0.1%, n = 53), low p53 (0.1% to 50%, n = 54), and high p53 (> 50%, n = 49). Overall, patients in the high-p53 group survived longer than those in the low or negative groups, with respective median survival durations of more than 65, 26, and 33 months (P = .002). The survival difference among the three groups was statistically significant for non-squamous cell (P = .008), but not for squamous cell (P = .17) carcinomas. Among lymph node-negative patients, the survival difference between groups was not statistically significant. However, among lymph node-positive patients (n = 78), more than 65% of the high-p53 group survived for more than 70 months, while the median survival durations for the low and negative groups were 21 and 18 months, respectively (P = .001). A Cox regression analysis with multiple covariates showed that p53 positivity in more than 50% of tumor cells was an independent prognostic factor for better outcome.
These results suggest that high expression of the p53 oncoprotein is a favorable prognostic factor in a subset of patients with NSCLC.</description><identifier>ISSN: 0732-183X</identifier><identifier>EISSN: 1527-7755</identifier><identifier>DOI: 10.1200/jco.1995.13.8.1893</identifier><identifier>PMID: 7636531</identifier><language>eng</language><publisher>Baltimore, MD: American Society of Clinical Oncology</publisher><subject>Adenocarcinoma - metabolism ; Adult ; Aged ; Biological and medical sciences ; Carcinoma, Large Cell - metabolism ; Carcinoma, Non-Small-Cell Lung - metabolism ; Carcinoma, Non-Small-Cell Lung - mortality ; Carcinoma, Non-Small-Cell Lung - pathology ; Carcinoma, Squamous Cell - metabolism ; Chi-Square Distribution ; Female ; Humans ; Immunohistochemistry ; Lung Neoplasms - metabolism ; Lung Neoplasms - mortality ; Lung Neoplasms - pathology ; Lymph Nodes - pathology ; Lymphatic Metastasis ; Male ; Medical sciences ; Middle Aged ; Pneumology ; Prognosis ; Regression Analysis ; Survival Rate ; Tumor Suppressor Protein p53 - metabolism ; Tumors of the respiratory system and mediastinum</subject><ispartof>Journal of clinical oncology, 1995-08, Vol.13 (8), p.1893-1903</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-b6cfa62dac19b875b52f31911128b98a5a5c5cc4b774e534c7d414130007a7b53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3729,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3616215$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7636531$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JIN SOO LEE</creatorcontrib><creatorcontrib>YOON, A</creatorcontrib><creatorcontrib>KALAPURAKAL, S. K</creatorcontrib><creatorcontrib>RO, J. Y</creatorcontrib><creatorcontrib>LEE, J. J</creatorcontrib><creatorcontrib>TU, N</creatorcontrib><creatorcontrib>HITTELMAN, W. N</creatorcontrib><creatorcontrib>HONG, W. K</creatorcontrib><title>Expression of p53 oncoprotein in non-small-cell lung cancer: a favorable prognostic factor</title><title>Journal of clinical oncology</title><addtitle>J Clin Oncol</addtitle><description>Mutation of the p53 gene is one of the most common genetic abnormalities found in lung cancer. The purpose of this study was to evaluate the prognostic value of p53 oncoprotein expression in patients with non-small-cell lung cancer (NSCLC).
We studied 156 resected primary NSCLCs by the immunohistochemical staining technique, using the p53 antibody DO7. There were 81 adenocarcinomas, 16 large-cell carcinomas, and 59 squamous cell carcinomas; stages were I in 67, II in 30, and III in 59 cases. For each tumor, the percentage of p53 positivity was calculated by scoring a minimum of 1,000 cells on an arbitrary intensity scale of 0 to 3+.
Overall, 103 (66%) tumors expressed p53 in more than 0.1% of cells, and squamous cell carcinomas tended to express more p53 than adenocarcinomas. Since 50% positivity marked the most distinct change in overall survival duration (P = .0008), we divided the cases into three groups, as follows: p53-negative (< or = 0.1%, n = 53), low p53 (0.1% to 50%, n = 54), and high p53 (> 50%, n = 49). Overall, patients in the high-p53 group survived longer than those in the low or negative groups, with respective median survival durations of more than 65, 26, and 33 months (P = .002). The survival difference among the three groups was statistically significant for non-squamous cell (P = .008), but not for squamous cell (P = .17) carcinomas. Among lymph node-negative patients, the survival difference between groups was not statistically significant. However, among lymph node-positive patients (n = 78), more than 65% of the high-p53 group survived for more than 70 months, while the median survival durations for the low and negative groups were 21 and 18 months, respectively (P = .001). A Cox regression analysis with multiple covariates showed that p53 positivity in more than 50% of tumor cells was an independent prognostic factor for better outcome.
These results suggest that high expression of the p53 oncoprotein is a favorable prognostic factor in a subset of patients with NSCLC.</description><subject>Adenocarcinoma - metabolism</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Large Cell - metabolism</subject><subject>Carcinoma, Non-Small-Cell Lung - metabolism</subject><subject>Carcinoma, Non-Small-Cell Lung - mortality</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Chi-Square Distribution</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - pathology</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>Prognosis</subject><subject>Regression Analysis</subject><subject>Survival Rate</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0732-183X</issn><issn>1527-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkUtLAzEUhYMoWh9_QBCyEHcz5iaTScadlPqi4EZB3IRMmmmnTJOaTH38e1MtVQgEcs859_AFoVMgOVBCLufG51BVPAeWyxxkxXbQADgVmRCc76IBEYxmINnLATqMcU4IFJLxfbQvSlZyBgP0OvpcBhtj6x32DV5yhr0zfhl8b1uH03HeZXGhuy4ztutwt3JTbLQzNlxhjRv97oOuO4uTZep87FuTHk3vwzHaa3QX7cnmPkLPN6On4V02fry9H16PM8O47LO6NI0u6UQbqGopeM1pw6ACACrrSmquueHGFLUQheWsMGJSQAGMECK0qDk7Qhe_uanB28rGXi3auO6qnfWrqJKPiaKgSUh_hSb4GINt1DK0Cx2-FBC1Bqoeho9qDVQBU1KtgSbT2SZ9VS_sZGvZEEzz881cR6O7JiQ0bdzKWAklhX8lZ-109tEGq36YplCq0jf-7fsGZeeLJQ</recordid><startdate>19950801</startdate><enddate>19950801</enddate><creator>JIN SOO LEE</creator><creator>YOON, A</creator><creator>KALAPURAKAL, S. 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K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-b6cfa62dac19b875b52f31911128b98a5a5c5cc4b774e534c7d414130007a7b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adenocarcinoma - metabolism</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Large Cell - metabolism</topic><topic>Carcinoma, Non-Small-Cell Lung - metabolism</topic><topic>Carcinoma, Non-Small-Cell Lung - mortality</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Chi-Square Distribution</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - pathology</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pneumology</topic><topic>Prognosis</topic><topic>Regression Analysis</topic><topic>Survival Rate</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JIN SOO LEE</creatorcontrib><creatorcontrib>YOON, A</creatorcontrib><creatorcontrib>KALAPURAKAL, S. K</creatorcontrib><creatorcontrib>RO, J. Y</creatorcontrib><creatorcontrib>LEE, J. J</creatorcontrib><creatorcontrib>TU, N</creatorcontrib><creatorcontrib>HITTELMAN, W. N</creatorcontrib><creatorcontrib>HONG, W. K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JIN SOO LEE</au><au>YOON, A</au><au>KALAPURAKAL, S. K</au><au>RO, J. Y</au><au>LEE, J. J</au><au>TU, N</au><au>HITTELMAN, W. N</au><au>HONG, W. K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of p53 oncoprotein in non-small-cell lung cancer: a favorable prognostic factor</atitle><jtitle>Journal of clinical oncology</jtitle><addtitle>J Clin Oncol</addtitle><date>1995-08-01</date><risdate>1995</risdate><volume>13</volume><issue>8</issue><spage>1893</spage><epage>1903</epage><pages>1893-1903</pages><issn>0732-183X</issn><eissn>1527-7755</eissn><abstract>Mutation of the p53 gene is one of the most common genetic abnormalities found in lung cancer. The purpose of this study was to evaluate the prognostic value of p53 oncoprotein expression in patients with non-small-cell lung cancer (NSCLC).
We studied 156 resected primary NSCLCs by the immunohistochemical staining technique, using the p53 antibody DO7. There were 81 adenocarcinomas, 16 large-cell carcinomas, and 59 squamous cell carcinomas; stages were I in 67, II in 30, and III in 59 cases. For each tumor, the percentage of p53 positivity was calculated by scoring a minimum of 1,000 cells on an arbitrary intensity scale of 0 to 3+.
Overall, 103 (66%) tumors expressed p53 in more than 0.1% of cells, and squamous cell carcinomas tended to express more p53 than adenocarcinomas. Since 50% positivity marked the most distinct change in overall survival duration (P = .0008), we divided the cases into three groups, as follows: p53-negative (< or = 0.1%, n = 53), low p53 (0.1% to 50%, n = 54), and high p53 (> 50%, n = 49). Overall, patients in the high-p53 group survived longer than those in the low or negative groups, with respective median survival durations of more than 65, 26, and 33 months (P = .002). The survival difference among the three groups was statistically significant for non-squamous cell (P = .008), but not for squamous cell (P = .17) carcinomas. Among lymph node-negative patients, the survival difference between groups was not statistically significant. However, among lymph node-positive patients (n = 78), more than 65% of the high-p53 group survived for more than 70 months, while the median survival durations for the low and negative groups were 21 and 18 months, respectively (P = .001). A Cox regression analysis with multiple covariates showed that p53 positivity in more than 50% of tumor cells was an independent prognostic factor for better outcome.
These results suggest that high expression of the p53 oncoprotein is a favorable prognostic factor in a subset of patients with NSCLC.</abstract><cop>Baltimore, MD</cop><pub>American Society of Clinical Oncology</pub><pmid>7636531</pmid><doi>10.1200/jco.1995.13.8.1893</doi><tpages>11</tpages></addata></record> |
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| ispartof | Journal of clinical oncology, 1995-08, Vol.13 (8), p.1893-1903 |
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| source | MEDLINE; American Society of Clinical Oncology Online Journals; Journals@Ovid Complete |
| subjects | Adenocarcinoma - metabolism Adult Aged Biological and medical sciences Carcinoma, Large Cell - metabolism Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Squamous Cell - metabolism Chi-Square Distribution Female Humans Immunohistochemistry Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology Lymph Nodes - pathology Lymphatic Metastasis Male Medical sciences Middle Aged Pneumology Prognosis Regression Analysis Survival Rate Tumor Suppressor Protein p53 - metabolism Tumors of the respiratory system and mediastinum |
| title | Expression of p53 oncoprotein in non-small-cell lung cancer: a favorable prognostic factor |
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