Long distance pathways of diffusion for dextran along fibre bundles in brain. Relevance for volume transmission
Texas Red-labelled dextran with a mol. wt of 3000 g mol, a marker for the extracellular space, was injected unilaterally into the neostriatum of adult rats (0.3–30 μ g μ l) and its distribution evaluated 1 min to 5 h later. Diffusion in the neuropil was observed with clearance starting after 30 min....
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| Veröffentlicht in: | Neuroreport 1995-05, Vol.6 (7), p.1005-1009 |
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| container_title | Neuroreport |
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| creator | Bjelke, Börje England, Robert Nicholson, Charles Rice, Margaret E Lindberg, Jakob Zoli, Michele Agnati, Luigi F Fuxe, Kjell |
| description | Texas Red-labelled dextran with a mol. wt of 3000 g mol, a marker for the extracellular space, was injected unilaterally into the neostriatum of adult rats (0.3–30 μ g μ l) and its distribution evaluated 1 min to 5 h later. Diffusion in the neuropil was observed with clearance starting after 30 min. After 10–15 min strong labelling along the myelinated fibre bundles was observed in the entire neostriatum. After about 20 min the labelling along the fibres reached into the corpus callosum and the overlaying deep layers of the cerebral cortex. A marked cellular uptake and accumulation of labelled dextran was found in putative perivascular pericytes. Thus, in the living brain preferential extracellular fluid pathways for diffusion exist, especially along fibre bundles, which allow the exchange of chemical signals between two distant regions. These may represent extracellular fluid pathways for volume transmission. |
| doi_str_mv | 10.1097/00001756-199505090-00014 |
| format | Article |
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Relevance for volume transmission</title><source>MEDLINE</source><source>Journals@Ovid Ovid Autoload</source><creator>Bjelke, Börje ; England, Robert ; Nicholson, Charles ; Rice, Margaret E ; Lindberg, Jakob ; Zoli, Michele ; Agnati, Luigi F ; Fuxe, Kjell</creator><creatorcontrib>Bjelke, Börje ; England, Robert ; Nicholson, Charles ; Rice, Margaret E ; Lindberg, Jakob ; Zoli, Michele ; Agnati, Luigi F ; Fuxe, Kjell</creatorcontrib><description>Texas Red-labelled dextran with a mol. wt of 3000 g mol, a marker for the extracellular space, was injected unilaterally into the neostriatum of adult rats (0.3–30 μ g μ l) and its distribution evaluated 1 min to 5 h later. Diffusion in the neuropil was observed with clearance starting after 30 min. After 10–15 min strong labelling along the myelinated fibre bundles was observed in the entire neostriatum. After about 20 min the labelling along the fibres reached into the corpus callosum and the overlaying deep layers of the cerebral cortex. A marked cellular uptake and accumulation of labelled dextran was found in putative perivascular pericytes. Thus, in the living brain preferential extracellular fluid pathways for diffusion exist, especially along fibre bundles, which allow the exchange of chemical signals between two distant regions. These may represent extracellular fluid pathways for volume transmission.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199505090-00014</identifier><identifier>PMID: 7543300</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Animals ; Biological and medical sciences ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Dextrans ; Diffusion ; Fluorescent Dyes ; Fundamental and applied biological sciences. Psychology ; Histocytochemistry ; Male ; Microscopy, Confocal ; Microscopy, Fluorescence ; Neostriatum - ultrastructure ; Nerve Fibers, Myelinated - ultrastructure ; Rats ; Rats, Sprague-Dawley ; Synaptic Transmission - physiology ; Vertebrates: nervous system and sense organs ; Xanthenes</subject><ispartof>Neuroreport, 1995-05, Vol.6 (7), p.1005-1009</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3304-fb30df995e957f634693e07f17698e5a516a0bf0a188024edf131e3d3bc6fcb83</citedby><cites>FETCH-LOGICAL-c3304-fb30df995e957f634693e07f17698e5a516a0bf0a188024edf131e3d3bc6fcb83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3505981$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7543300$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bjelke, Börje</creatorcontrib><creatorcontrib>England, Robert</creatorcontrib><creatorcontrib>Nicholson, Charles</creatorcontrib><creatorcontrib>Rice, Margaret E</creatorcontrib><creatorcontrib>Lindberg, Jakob</creatorcontrib><creatorcontrib>Zoli, Michele</creatorcontrib><creatorcontrib>Agnati, Luigi F</creatorcontrib><creatorcontrib>Fuxe, Kjell</creatorcontrib><title>Long distance pathways of diffusion for dextran along fibre bundles in brain. Relevance for volume transmission</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>Texas Red-labelled dextran with a mol. wt of 3000 g mol, a marker for the extracellular space, was injected unilaterally into the neostriatum of adult rats (0.3–30 μ g μ l) and its distribution evaluated 1 min to 5 h later. Diffusion in the neuropil was observed with clearance starting after 30 min. After 10–15 min strong labelling along the myelinated fibre bundles was observed in the entire neostriatum. After about 20 min the labelling along the fibres reached into the corpus callosum and the overlaying deep layers of the cerebral cortex. A marked cellular uptake and accumulation of labelled dextran was found in putative perivascular pericytes. Thus, in the living brain preferential extracellular fluid pathways for diffusion exist, especially along fibre bundles, which allow the exchange of chemical signals between two distant regions. These may represent extracellular fluid pathways for volume transmission.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Dextrans</subject><subject>Diffusion</subject><subject>Fluorescent Dyes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Histocytochemistry</subject><subject>Male</subject><subject>Microscopy, Confocal</subject><subject>Microscopy, Fluorescence</subject><subject>Neostriatum - ultrastructure</subject><subject>Nerve Fibers, Myelinated - ultrastructure</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Synaptic Transmission - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Xanthenes</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkstOLCEQhonR6Hh5BBMWJ-5aQaCB5YnxlkxiYjRxR-juwmllmjnQPaNvL-3MmZ2RBSRV318U9YMQpuScEi0vSF5UirKgWgsiiCbFGOE7aEK5ZIUQ6mUXTYgWuuC6FAfoMKW3jGhC1T7al4IzRsgEhWnoXnHTpt52NeCF7Wcr-5lwcDno3JDa0GEXIm7go4-2w9aPAtdWEXA1dI2HhNsOV9G23Tl-BA_L70qjZhn8MAc86tK8TWOtY7TnrE9wsjmP0PPN9dPVXTF9uL2_-jst6twXL1zFSOPy20AL6UrGS82ASEdlqRUIK2hpSeWIpUqRSw6No4wCa1hVl66uFDtCZ-u6ixj-DZB6kxuowXvbQRiSkTIPgCr-K0hLqS7zlkG1BusYUorgzCK2cxs_DSVmNMX8N8VsTTHfpmTp6eaOoZpDsxVuXMj5P5u8TbX1Ls-rbtMWY7mYVjRjfI2tgu8hpnc_rCCaGVjfz8xPX4J9AbkWpN0</recordid><startdate>19950509</startdate><enddate>19950509</enddate><creator>Bjelke, Börje</creator><creator>England, Robert</creator><creator>Nicholson, Charles</creator><creator>Rice, Margaret E</creator><creator>Lindberg, Jakob</creator><creator>Zoli, Michele</creator><creator>Agnati, Luigi F</creator><creator>Fuxe, Kjell</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19950509</creationdate><title>Long distance pathways of diffusion for dextran along fibre bundles in brain. Relevance for volume transmission</title><author>Bjelke, Börje ; England, Robert ; Nicholson, Charles ; Rice, Margaret E ; Lindberg, Jakob ; Zoli, Michele ; Agnati, Luigi F ; Fuxe, Kjell</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3304-fb30df995e957f634693e07f17698e5a516a0bf0a188024edf131e3d3bc6fcb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Dextrans</topic><topic>Diffusion</topic><topic>Fluorescent Dyes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Histocytochemistry</topic><topic>Male</topic><topic>Microscopy, Confocal</topic><topic>Microscopy, Fluorescence</topic><topic>Neostriatum - ultrastructure</topic><topic>Nerve Fibers, Myelinated - ultrastructure</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Synaptic Transmission - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Xanthenes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bjelke, Börje</creatorcontrib><creatorcontrib>England, Robert</creatorcontrib><creatorcontrib>Nicholson, Charles</creatorcontrib><creatorcontrib>Rice, Margaret E</creatorcontrib><creatorcontrib>Lindberg, Jakob</creatorcontrib><creatorcontrib>Zoli, Michele</creatorcontrib><creatorcontrib>Agnati, Luigi F</creatorcontrib><creatorcontrib>Fuxe, Kjell</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bjelke, Börje</au><au>England, Robert</au><au>Nicholson, Charles</au><au>Rice, Margaret E</au><au>Lindberg, Jakob</au><au>Zoli, Michele</au><au>Agnati, Luigi F</au><au>Fuxe, Kjell</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long distance pathways of diffusion for dextran along fibre bundles in brain. Relevance for volume transmission</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1995-05-09</date><risdate>1995</risdate><volume>6</volume><issue>7</issue><spage>1005</spage><epage>1009</epage><pages>1005-1009</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>Texas Red-labelled dextran with a mol. wt of 3000 g mol, a marker for the extracellular space, was injected unilaterally into the neostriatum of adult rats (0.3–30 μ g μ l) and its distribution evaluated 1 min to 5 h later. Diffusion in the neuropil was observed with clearance starting after 30 min. After 10–15 min strong labelling along the myelinated fibre bundles was observed in the entire neostriatum. After about 20 min the labelling along the fibres reached into the corpus callosum and the overlaying deep layers of the cerebral cortex. A marked cellular uptake and accumulation of labelled dextran was found in putative perivascular pericytes. Thus, in the living brain preferential extracellular fluid pathways for diffusion exist, especially along fibre bundles, which allow the exchange of chemical signals between two distant regions. These may represent extracellular fluid pathways for volume transmission.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>7543300</pmid><doi>10.1097/00001756-199505090-00014</doi><tpages>5</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Dextrans Diffusion Fluorescent Dyes Fundamental and applied biological sciences. Psychology Histocytochemistry Male Microscopy, Confocal Microscopy, Fluorescence Neostriatum - ultrastructure Nerve Fibers, Myelinated - ultrastructure Rats Rats, Sprague-Dawley Synaptic Transmission - physiology Vertebrates: nervous system and sense organs Xanthenes |
| title | Long distance pathways of diffusion for dextran along fibre bundles in brain. Relevance for volume transmission |
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