Pilocytic Astrocytomas: Well-Demarcated Magnetic Resonance Appearance Despite Frequent Infiltration Histologically
To determine the magnetic resonance imaging (MRI) characteristics of pilocytic astro-cytomas and to correlate them with the histopathologic findings. MRI examinations and histopathologic findings in 56 patients with pilocytic astrocytomas were retrospectively reviewed. In 38 patients, findings on MR...
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| Veröffentlicht in: | Mayo Clinic proceedings 1995-08, Vol.70 (8), p.747-751 |
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| creator | Coakley, Kevin J. Huston, John Scheithauer, Bernd W. Forbes, Glenn Kelly, Patrick J. |
| description | To determine the magnetic resonance imaging (MRI) characteristics of pilocytic astro-cytomas and to correlate them with the histopathologic findings.
MRI examinations and histopathologic findings in 56 patients with pilocytic astrocytomas were retrospectively reviewed. In 38 patients, findings on MRI were compared with those on computed tomography.
The tumors occurred at all levels of the central nervous system, including the spinal cord. The intracranial tumors were periventricular (73%) or periaqueductal (9%). All tumors were typical pilocytic astrocytomas and were grade 1 on the basis of the World Health Organization classification. At operation, they were often circumscribed and cystic. Radiologically, the tumors were well demarcated (96%), had benign morphologic features, and almost always showed enhancement (94 %).
MRI of pilocytic astrocytomas typically demonstrated a relatively large, sharply demarcated periventricular mass with pronounced contrast enhancement but minimal or no associated edema. Often, the tumors were cystic on MRI. Despite the well-demarcated appearance grossly and on MRI, pathologic review showed that many of these tumors (64%) infiltrated the surrounding parenchyma, particularly the white matter. |
| doi_str_mv | 10.4065/70.8.747 |
| format | Article |
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MRI examinations and histopathologic findings in 56 patients with pilocytic astrocytomas were retrospectively reviewed. In 38 patients, findings on MRI were compared with those on computed tomography.
The tumors occurred at all levels of the central nervous system, including the spinal cord. The intracranial tumors were periventricular (73%) or periaqueductal (9%). All tumors were typical pilocytic astrocytomas and were grade 1 on the basis of the World Health Organization classification. At operation, they were often circumscribed and cystic. Radiologically, the tumors were well demarcated (96%), had benign morphologic features, and almost always showed enhancement (94 %).
MRI of pilocytic astrocytomas typically demonstrated a relatively large, sharply demarcated periventricular mass with pronounced contrast enhancement but minimal or no associated edema. Often, the tumors were cystic on MRI. Despite the well-demarcated appearance grossly and on MRI, pathologic review showed that many of these tumors (64%) infiltrated the surrounding parenchyma, particularly the white matter.</description><identifier>ISSN: 0025-6196</identifier><identifier>EISSN: 1942-5546</identifier><identifier>DOI: 10.4065/70.8.747</identifier><identifier>PMID: 7630212</identifier><identifier>CODEN: MACPAJ</identifier><language>eng</language><publisher>Rochester, MN: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Astrocytoma - diagnostic imaging ; Astrocytoma - pathology ; Biological and medical sciences ; Brain Neoplasms - diagnostic imaging ; Brain Neoplasms - pathology ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Neurology ; Retrospective Studies ; Tomography, X-Ray Computed ; Tumors of the nervous system. Phacomatoses</subject><ispartof>Mayo Clinic proceedings, 1995-08, Vol.70 (8), p.747-751</ispartof><rights>1995 Mayo Foundation for Medical Education and Research</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-6f2d8fe7dc0addac21bdf848a69824f06a2a6296335a10b517e64ea39d95aa7c3</citedby><cites>FETCH-LOGICAL-c416t-6f2d8fe7dc0addac21bdf848a69824f06a2a6296335a10b517e64ea39d95aa7c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3613826$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7630212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coakley, Kevin J.</creatorcontrib><creatorcontrib>Huston, John</creatorcontrib><creatorcontrib>Scheithauer, Bernd W.</creatorcontrib><creatorcontrib>Forbes, Glenn</creatorcontrib><creatorcontrib>Kelly, Patrick J.</creatorcontrib><title>Pilocytic Astrocytomas: Well-Demarcated Magnetic Resonance Appearance Despite Frequent Infiltration Histologically</title><title>Mayo Clinic proceedings</title><addtitle>Mayo Clin Proc</addtitle><description>To determine the magnetic resonance imaging (MRI) characteristics of pilocytic astro-cytomas and to correlate them with the histopathologic findings.
MRI examinations and histopathologic findings in 56 patients with pilocytic astrocytomas were retrospectively reviewed. In 38 patients, findings on MRI were compared with those on computed tomography.
The tumors occurred at all levels of the central nervous system, including the spinal cord. The intracranial tumors were periventricular (73%) or periaqueductal (9%). All tumors were typical pilocytic astrocytomas and were grade 1 on the basis of the World Health Organization classification. At operation, they were often circumscribed and cystic. Radiologically, the tumors were well demarcated (96%), had benign morphologic features, and almost always showed enhancement (94 %).
MRI of pilocytic astrocytomas typically demonstrated a relatively large, sharply demarcated periventricular mass with pronounced contrast enhancement but minimal or no associated edema. Often, the tumors were cystic on MRI. Despite the well-demarcated appearance grossly and on MRI, pathologic review showed that many of these tumors (64%) infiltrated the surrounding parenchyma, particularly the white matter.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Astrocytoma - diagnostic imaging</subject><subject>Astrocytoma - pathology</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - diagnostic imaging</subject><subject>Brain Neoplasms - pathology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Retrospective Studies</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>0025-6196</issn><issn>1942-5546</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkE1rGzEQhkVoSZwP6B8o7KGEXNbR10q7uZmkaQIJCaWlRzGWZoPCerWR5IL_feTa5NLTDMzDzLwPIV8YnUuqmktN5-1cS31AZqyTvG4aqT6RGaW8qRXr1BE5TumVUqq7Th6SQ60E5YzPSHz2Q7Cb7G21SDlu27CCdFX9wWGob3AF0UJGVz3Cy4hb7CemMMJosVpME0L8195gmnzG6jbi2xrHXN2PvR9yhOzDWN35lMMQXryFYdicks89DAnP9vWE_L79_uv6rn54-nF_vXiorWQq16rnru1RO0vBObCcLV3fyhZU13LZUwUcFO-UEA0wumyYRiURROe6BkBbcULOd3unGMpTKZuVT7bEghHDOhmtpRBM8wJe7EAbQ0oRezNFX4JvDKNmq9doalpT9Bb0637nerlC9wHufZb5t_0cUgnbb-349IEJxUTLVcH4DsOS_6_HaJL1WEQ6H9Fm44L___Y7rZyUrA</recordid><startdate>19950801</startdate><enddate>19950801</enddate><creator>Coakley, Kevin J.</creator><creator>Huston, John</creator><creator>Scheithauer, Bernd W.</creator><creator>Forbes, Glenn</creator><creator>Kelly, Patrick J.</creator><general>Elsevier Inc</general><general>Mayo Medical Ventures</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950801</creationdate><title>Pilocytic Astrocytomas: Well-Demarcated Magnetic Resonance Appearance Despite Frequent Infiltration Histologically</title><author>Coakley, Kevin J. ; Huston, John ; Scheithauer, Bernd W. ; Forbes, Glenn ; Kelly, Patrick J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-6f2d8fe7dc0addac21bdf848a69824f06a2a6296335a10b517e64ea39d95aa7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Astrocytoma - diagnostic imaging</topic><topic>Astrocytoma - pathology</topic><topic>Biological and medical sciences</topic><topic>Brain Neoplasms - diagnostic imaging</topic><topic>Brain Neoplasms - pathology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Retrospective Studies</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coakley, Kevin J.</creatorcontrib><creatorcontrib>Huston, John</creatorcontrib><creatorcontrib>Scheithauer, Bernd W.</creatorcontrib><creatorcontrib>Forbes, Glenn</creatorcontrib><creatorcontrib>Kelly, Patrick J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Mayo Clinic proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coakley, Kevin J.</au><au>Huston, John</au><au>Scheithauer, Bernd W.</au><au>Forbes, Glenn</au><au>Kelly, Patrick J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pilocytic Astrocytomas: Well-Demarcated Magnetic Resonance Appearance Despite Frequent Infiltration Histologically</atitle><jtitle>Mayo Clinic proceedings</jtitle><addtitle>Mayo Clin Proc</addtitle><date>1995-08-01</date><risdate>1995</risdate><volume>70</volume><issue>8</issue><spage>747</spage><epage>751</epage><pages>747-751</pages><issn>0025-6196</issn><eissn>1942-5546</eissn><coden>MACPAJ</coden><abstract>To determine the magnetic resonance imaging (MRI) characteristics of pilocytic astro-cytomas and to correlate them with the histopathologic findings.
MRI examinations and histopathologic findings in 56 patients with pilocytic astrocytomas were retrospectively reviewed. In 38 patients, findings on MRI were compared with those on computed tomography.
The tumors occurred at all levels of the central nervous system, including the spinal cord. The intracranial tumors were periventricular (73%) or periaqueductal (9%). All tumors were typical pilocytic astrocytomas and were grade 1 on the basis of the World Health Organization classification. At operation, they were often circumscribed and cystic. Radiologically, the tumors were well demarcated (96%), had benign morphologic features, and almost always showed enhancement (94 %).
MRI of pilocytic astrocytomas typically demonstrated a relatively large, sharply demarcated periventricular mass with pronounced contrast enhancement but minimal or no associated edema. Often, the tumors were cystic on MRI. Despite the well-demarcated appearance grossly and on MRI, pathologic review showed that many of these tumors (64%) infiltrated the surrounding parenchyma, particularly the white matter.</abstract><cop>Rochester, MN</cop><pub>Elsevier Inc</pub><pmid>7630212</pmid><doi>10.4065/70.8.747</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Astrocytoma - diagnostic imaging Astrocytoma - pathology Biological and medical sciences Brain Neoplasms - diagnostic imaging Brain Neoplasms - pathology Child Child, Preschool Female Humans Infant Magnetic Resonance Imaging Male Medical sciences Middle Aged Neurology Retrospective Studies Tomography, X-Ray Computed Tumors of the nervous system. Phacomatoses |
| title | Pilocytic Astrocytomas: Well-Demarcated Magnetic Resonance Appearance Despite Frequent Infiltration Histologically |
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