Berenil [1,3-bis(4'-amidinophenyl)triazene] binding to DNA duplexes and to a RNA duplex: evidence for both intercalative and minor groove binding properties

Berenil is an antitrypanosomal agent that binds to nucleic acid duplexes. The generally accepted mode of berenil binding is via complexation into the minor groove of AT-rich domains of DNA double helices. We find that berenil can bind to RNA as well as DNA duplexes, while exhibiting properties chara...

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Veröffentlicht in:	Biochemistry (Easton) 1995-08, Vol.34 (31), p.9962-9976
Hauptverfasser:	Pilch, D S, Kirolos, M A, Liu, X, Plum, G E, Breslauer, K J
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Calorimetry Circular Dichroism Diminazene - analogs & derivatives Diminazene - metabolism DNA - metabolism Hot Temperature Intercalating Agents - metabolism Magnetic Resonance Spectroscopy Models, Chemical Nucleic Acid Denaturation RNA, Double-Stranded - metabolism Spectrophotometry, Ultraviolet Trypanocidal Agents - metabolism Viscosity
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