Comparison of the effects of sumatriptan and the NK1 antagonist CP-99,994 on plasma extravasation in dura mater and c-fos mRNA expression in trigeminal nucleus caudalis of rats

Dural plasma extravasation produced by electrical stimulation of the trigeminal ganglion was measured in rats and the concomitant expression of c-fos mRNA produced in the trigeminal nucleus caudalis (NtV) was measured using in situ hybridization techniques. The non-peptide NK1 receptor selective ant...

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Veröffentlicht in:	Neuropharmacology 1995-03, Vol.34 (3), p.255-261
Hauptverfasser:	SHEPHEARD, S. L, WILLIAMSON, D. J, WILLIAMS, J, HILL, R. G, HARGREAVES, R. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood-Brain Barrier - drug effects Capillary Permeability - drug effects Cardiovascular system Dura Mater - drug effects Dura Mater - metabolism Electric Stimulation Gene Expression - drug effects Genes, fos - drug effects In Situ Hybridization Male Medical sciences Neurokinin A - antagonists & inhibitors Neurokinin-1 Receptor Antagonists Pharmacology. Drug treatments Piperidines - pharmacology Rats Rats, Sprague-Dawley RNA, Messenger - biosynthesis Sumatriptan - pharmacology Trigeminal Ganglion - anatomy & histology Trigeminal Ganglion - drug effects Trigeminal Ganglion - metabolism Vasodilator agents. Cerebral vasodilators
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