Prevalence of antibody to Chlamydia trachomatis in spontaneous abortion and infertility
A higher prevalence of Chlamydia trachomatis antibody occurred in 57.6% of women with recurrent abortion, but not in their male partners, compared to 33.7% of normal pregnant women (p < 0.01) and 44.2% of infertile women (NS). The mean titer for the recurrent abortion group was not significantly...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1987-02, Vol.156 (2), p.291-296 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Quinn, P.A. Petric, M. Barkin, M. Butany, J. Derzko, C. Gysler, M. Lie, K.I. Shewchuck, A.B. Shuber, J. Ryan, E. Chipman, M.L. |
| description | A higher prevalence of Chlamydia trachomatis antibody occurred in 57.6% of women with recurrent abortion, but not in their male partners, compared to 33.7% of normal pregnant women (p < 0.01) and 44.2% of infertile women (NS). The mean titer for the recurrent abortion group was not significantly elevated, compared to controls. Women with blocked fallopian tubes had the highest prevalence of elevated titers (p < 0.01) and the highest mean titer (p < 0.001). Despite multiple testing, no women or men were chlamydia culture-positive. The lack of isolation among patients with antibody could be due to cryptic infection at a site not amenable to culture or to inhibition by secretory IgA. There could also be nonspecific stimulation of chlamydial antibody caused by other infections such as mycoplasma. The presence, though at a low level, of antibody in culture-negative patients suggests chlamydia may not be directly associated with recurrent abortion but reflect previous exposure to chlamydia or an altered immune system. |
| doi_str_mv | 10.1016/0002-9378(87)90270-5 |
| format | Article |
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The mean titer for the recurrent abortion group was not significantly elevated, compared to controls. Women with blocked fallopian tubes had the highest prevalence of elevated titers (p < 0.01) and the highest mean titer (p < 0.001). Despite multiple testing, no women or men were chlamydia culture-positive. The lack of isolation among patients with antibody could be due to cryptic infection at a site not amenable to culture or to inhibition by secretory IgA. There could also be nonspecific stimulation of chlamydial antibody caused by other infections such as mycoplasma. The presence, though at a low level, of antibody in culture-negative patients suggests chlamydia may not be directly associated with recurrent abortion but reflect previous exposure to chlamydia or an altered immune system.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/0002-9378(87)90270-5</identifier><identifier>PMID: 3826162</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Elsevier Inc</publisher><subject>Abortion, Habitual - immunology ; Antibodies, Bacterial - analysis ; antibody ; Bacterial diseases ; Bacterial diseases of the genital system ; Biological and medical sciences ; Chlamydia ; Chlamydia trachomatis - immunology ; Female ; Human bacterial diseases ; Humans ; Infectious diseases ; infertility ; Infertility, Female - immunology ; Infertility, Male - immunology ; Male ; Medical sciences ; Pregnancy ; recurrent spontaneous abortion</subject><ispartof>American journal of obstetrics and gynecology, 1987-02, Vol.156 (2), p.291-296</ispartof><rights>1987</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-9734e62d1256ae6dd858145b79966446db1a5cec9d8598edcafdfa09b4e8d0903</citedby><cites>FETCH-LOGICAL-c386t-9734e62d1256ae6dd858145b79966446db1a5cec9d8598edcafdfa09b4e8d0903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9378(87)90270-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8302498$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3826162$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quinn, P.A.</creatorcontrib><creatorcontrib>Petric, M.</creatorcontrib><creatorcontrib>Barkin, M.</creatorcontrib><creatorcontrib>Butany, J.</creatorcontrib><creatorcontrib>Derzko, C.</creatorcontrib><creatorcontrib>Gysler, M.</creatorcontrib><creatorcontrib>Lie, K.I.</creatorcontrib><creatorcontrib>Shewchuck, A.B.</creatorcontrib><creatorcontrib>Shuber, J.</creatorcontrib><creatorcontrib>Ryan, E.</creatorcontrib><creatorcontrib>Chipman, M.L.</creatorcontrib><title>Prevalence of antibody to Chlamydia trachomatis in spontaneous abortion and infertility</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>A higher prevalence of Chlamydia trachomatis antibody occurred in 57.6% of women with recurrent abortion, but not in their male partners, compared to 33.7% of normal pregnant women (p < 0.01) and 44.2% of infertile women (NS). The mean titer for the recurrent abortion group was not significantly elevated, compared to controls. Women with blocked fallopian tubes had the highest prevalence of elevated titers (p < 0.01) and the highest mean titer (p < 0.001). Despite multiple testing, no women or men were chlamydia culture-positive. The lack of isolation among patients with antibody could be due to cryptic infection at a site not amenable to culture or to inhibition by secretory IgA. There could also be nonspecific stimulation of chlamydial antibody caused by other infections such as mycoplasma. The presence, though at a low level, of antibody in culture-negative patients suggests chlamydia may not be directly associated with recurrent abortion but reflect previous exposure to chlamydia or an altered immune system.</description><subject>Abortion, Habitual - immunology</subject><subject>Antibodies, Bacterial - analysis</subject><subject>antibody</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the genital system</subject><subject>Biological and medical sciences</subject><subject>Chlamydia</subject><subject>Chlamydia trachomatis - immunology</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>infertility</subject><subject>Infertility, Female - immunology</subject><subject>Infertility, Male - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>recurrent spontaneous abortion</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVoSTdp_kEKPoTSHpxKsq2PS6EsTRMINIeWHMVYGhMF29pI2sD--8rZZY89DcP7vMPwEHLJ6DWjTHyjlPJaN1J9UfKrplzSujshK0a1rIUS6h1ZHZEP5Cyl52Xlmp-S00ZxwQRfkceHiK8w4myxCkMFc_Z9cLsqh2r9NMK0cx6qHME-hQmyT5Wfq7QJc4YZwzZV0IeYfZhL05VswLKNPu8-kvcDjAkvDvOc_L35-Wd9W9___nW3_nFf20aJXGvZtCi4Y7wTgMI51SnWdr3UWoi2Fa5n0Fm0ugRaobMwuAGo7ltUjmranJPP-7ubGF62mLKZfLI4jvv_jJQt15LzArZ70MaQUsTBbKKfIO4Mo2bxaRY7ZpFllDRvPk1Xap8O97f9hO5YOggs-dUhh2RhHCLM1qcjphrKW60K9n2PYXHx6jGaZP0i3fmINhsX_P__-Ac2y5Jm</recordid><startdate>19870201</startdate><enddate>19870201</enddate><creator>Quinn, P.A.</creator><creator>Petric, M.</creator><creator>Barkin, M.</creator><creator>Butany, J.</creator><creator>Derzko, C.</creator><creator>Gysler, M.</creator><creator>Lie, K.I.</creator><creator>Shewchuck, A.B.</creator><creator>Shuber, J.</creator><creator>Ryan, E.</creator><creator>Chipman, M.L.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870201</creationdate><title>Prevalence of antibody to Chlamydia trachomatis in spontaneous abortion and infertility</title><author>Quinn, P.A. ; Petric, M. ; Barkin, M. ; Butany, J. ; Derzko, C. ; Gysler, M. ; Lie, K.I. ; Shewchuck, A.B. ; Shuber, J. ; Ryan, E. ; Chipman, M.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-9734e62d1256ae6dd858145b79966446db1a5cec9d8598edcafdfa09b4e8d0903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Abortion, Habitual - immunology</topic><topic>Antibodies, Bacterial - analysis</topic><topic>antibody</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the genital system</topic><topic>Biological and medical sciences</topic><topic>Chlamydia</topic><topic>Chlamydia trachomatis - immunology</topic><topic>Female</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>infertility</topic><topic>Infertility, Female - immunology</topic><topic>Infertility, Male - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>recurrent spontaneous abortion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quinn, P.A.</creatorcontrib><creatorcontrib>Petric, M.</creatorcontrib><creatorcontrib>Barkin, M.</creatorcontrib><creatorcontrib>Butany, J.</creatorcontrib><creatorcontrib>Derzko, C.</creatorcontrib><creatorcontrib>Gysler, M.</creatorcontrib><creatorcontrib>Lie, K.I.</creatorcontrib><creatorcontrib>Shewchuck, A.B.</creatorcontrib><creatorcontrib>Shuber, J.</creatorcontrib><creatorcontrib>Ryan, E.</creatorcontrib><creatorcontrib>Chipman, M.L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quinn, P.A.</au><au>Petric, M.</au><au>Barkin, M.</au><au>Butany, J.</au><au>Derzko, C.</au><au>Gysler, M.</au><au>Lie, K.I.</au><au>Shewchuck, A.B.</au><au>Shuber, J.</au><au>Ryan, E.</au><au>Chipman, M.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of antibody to Chlamydia trachomatis in spontaneous abortion and infertility</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1987-02-01</date><risdate>1987</risdate><volume>156</volume><issue>2</issue><spage>291</spage><epage>296</epage><pages>291-296</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>A higher prevalence of Chlamydia trachomatis antibody occurred in 57.6% of women with recurrent abortion, but not in their male partners, compared to 33.7% of normal pregnant women (p < 0.01) and 44.2% of infertile women (NS). The mean titer for the recurrent abortion group was not significantly elevated, compared to controls. Women with blocked fallopian tubes had the highest prevalence of elevated titers (p < 0.01) and the highest mean titer (p < 0.001). Despite multiple testing, no women or men were chlamydia culture-positive. The lack of isolation among patients with antibody could be due to cryptic infection at a site not amenable to culture or to inhibition by secretory IgA. There could also be nonspecific stimulation of chlamydial antibody caused by other infections such as mycoplasma. The presence, though at a low level, of antibody in culture-negative patients suggests chlamydia may not be directly associated with recurrent abortion but reflect previous exposure to chlamydia or an altered immune system.</abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>3826162</pmid><doi>10.1016/0002-9378(87)90270-5</doi><tpages>6</tpages></addata></record> |
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| subjects | Abortion, Habitual - immunology Antibodies, Bacterial - analysis antibody Bacterial diseases Bacterial diseases of the genital system Biological and medical sciences Chlamydia Chlamydia trachomatis - immunology Female Human bacterial diseases Humans Infectious diseases infertility Infertility, Female - immunology Infertility, Male - immunology Male Medical sciences Pregnancy recurrent spontaneous abortion |
| title | Prevalence of antibody to Chlamydia trachomatis in spontaneous abortion and infertility |
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