Divalent cation modulation of the ribonuclease functions of human immunodeficiency virus reverse transcriptase

The stimulatory effect of Mg2+ and Mn2+ on the ribonuclease H (RNase H) functions of HIV-1 reverse transcriptase (RT) has been evaluated using a model 90-nt RNA template/36-nt DNA primer. Wild type enzyme exhibits similar endonuclease and directional processing activities in response to both cations...

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Veröffentlicht in:	Biochemistry (Easton) 1995-08, Vol.34 (31), p.9936-9943
Hauptverfasser:	Cirino, Nick M, Cameron, Craig E, Smith, Jeffrey S, Roth, Monica J, Benkovic, Stephen J, Le Grice, Stuart F. J
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Base Sequence Binding Sites Cations, Divalent - pharmacology DNA, Viral - metabolism DNA-Directed DNA Polymerase - metabolism HIV Reverse Transcriptase HIV-1 - enzymology HIV-1 - growth & development Magnesium - pharmacology Manganese - pharmacology Molecular Sequence Data Nucleic Acid Heteroduplexes - metabolism Recombinant Proteins - drug effects Recombinant Proteins - metabolism Ribonuclease H - drug effects Ribonuclease H - metabolism RNA RNA, Transfer - metabolism RNA, Viral - metabolism RNA-Directed DNA Polymerase - drug effects RNA-Directed DNA Polymerase - metabolism Substrate Specificity
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