Crystal structure of a replication fork single-stranded DNA binding protein (T4 gp32) complexed to DNA

The single-stranded DNA (ssDNA) binding protein gp32 from bacteriophage T4 is essential for T4 DNA replication, recombination and repair. In vivo gp32 binds ssDNA as the replication fork advances and stimulates replisome processivity and accuracy by a factor of several hundred. Gp32 binding affects...

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Veröffentlicht in:	Nature (London) 1995-07, Vol.376 (6538), p.362-366
Hauptverfasser:	Shamoo, Yousif, Friedman, Alan M, Parsons, Mark R, Konigsberg, William H, Steitz, Thomas A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacteriophage T4 - chemistry Biochemistry Biological and medical sciences Computer Graphics Crystalline structure Crystallography, X-Ray Crystals Deoxyribonucleic acid DNA DNA, Single-Stranded - chemistry DNA-Binding Proteins - chemistry Electrochemistry Fundamental and applied biological sciences. Psychology Molecular biophysics Molecular Sequence Data Nucleic Acid Conformation phage T4 Protein Binding Protein Conformation Proteins Structure in molecular biology Viral Proteins - chemistry
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