Na,K-ATPase Inhibitors from Bovine Hypothalamus and Human Plasma Are Different from Ouabain: Nanogram Scale CD Structural Analysis

The specific, high affinity binding of plant-derived digitalis glycosides by the mammalian sodium and potassium transporting adenosine triphosphatase (Na,K-ATPase, or sodium pump), a plasma membrane enzyme with critical physiological importance in mammalian tissues, has raised the possibility that a...

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Veröffentlicht in:	Biochemistry (Easton) 1995-08, Vol.34 (31), p.9893-9896
Hauptverfasser:	Zhao, Ning, Lo, Lee-Chiang, Berova, Nina, Nakanishi, Koji, Tymiak, Adrienne A, Ludens, James H, Haupert, Garner T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle Chromatography, High Pressure Liquid Circular Dichroism Enzyme Inhibitors - blood Enzyme Inhibitors - chemistry Humans Hypothalamus - chemistry Ouabain - analogs & derivatives Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors
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