A molecular model for the interaction between vorozole and other non-steroidal inhibitors and human cytochrome P450 19 ( P450 Aromatase)

In a previous study (Vanden Bossche et al., Breast Cancer Res. Treat. 30 (1994) 43) the interaction between (+)- S-vorozole and the I-helix of cytochrome P450 19 ( P450 aromatase) has been reported. In the present study we extended the “I-helix model” by incorporating the C-terminus of P450 aromatas...

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Veröffentlicht in:	Journal of steroid biochemistry and molecular biology 1995-06, Vol.53 (1), p.191-197
Hauptverfasser:	Koymans, Luc M.H., Moereels, Henri, Bossche, Hugo Vanden
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Androstenedione - metabolism Antineoplastic agents Aromatase - chemistry Aromatase - metabolism Aromatase Inhibitors Binding Sites Biological and medical sciences General aspects Humans In Vitro Techniques Medical sciences Models, Molecular Molecular Sequence Data Pharmacology. Drug treatments Protein Structure, Secondary Protein Structure, Tertiary Sequence Alignment Triazoles - chemistry Triazoles - pharmacology
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