Biosynthesis and localization of inhibin in human prostate

Inhibin biosynthesis by human prostatic tissue was investigated in vitro. Serum levels of inhibin as well as tissue concentrations in different cells and zones of the normal and benign hyperplastic prostates were determined. Immunocytochemical localization of inhibin identified the involvement of ep...

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Veröffentlicht in:	The Prostate 1987, Vol.10 (1), p.33-43
Hauptverfasser:	Sathe, Vinaya S., Sheth, Nandini A., Phadke, Meena A., Sheth, Anil R., Zaveri, Jayesh P.
Format:	Artikel
Sprache:	eng
Schlagworte:	benign prostatic hyperplasia Biological and medical sciences epithelial cells Estradiol - pharmacology Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Humans Inhibins - analysis Inhibins - biosynthesis Male Mammalian male genital system Prostate - analysis Prostate - anatomy & histology Prostate - drug effects Prostate - metabolism Prostatic Hyperplasia - metabolism prostatic inhibin Radioimmunoassay stromal cells Testosterone - pharmacology Vertebrates: reproduction
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Zusammenfassung:	Inhibin biosynthesis by human prostatic tissue was investigated in vitro. Serum levels of inhibin as well as tissue concentrations in different cells and zones of the normal and benign hyperplastic prostates were determined. Immunocytochemical localization of inhibin identified the involvement of epithelial but not stromal cells in the synthesis and release of prostatic inhibin into the circulation. The endocrine and paracrine functions of prostatic inhibin remain to be elucidated.
ISSN:	0270-4137 1097-0045
DOI:	10.1002/pros.2990100107