Antiestrogens: Mechanisms and actions in target cells

Antiestrogens, acting via the estrogen receptor (ER) evoke conformational changes in the ER and inhibit the effects of estrogens as well as exerting anti-growth factor activities. Although the binding of estrogens and antiestrogens is mutually competitive, studies with ER mutants indicate that some...

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Veröffentlicht in:	Journal of steroid biochemistry and molecular biology 1995-06, Vol.53 (1), p.387-393
Hauptverfasser:	Katzenellenbogen, Benita S., Montano, Monica M., Le Goff, Pascale, Schodin, David J., Kraus, W.Lee, Bhardwaj, Bhavna, Fujimoto, Nariaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cyclic AMP - physiology Estradiol - analogs & derivatives Estradiol - pharmacology Estrogen Antagonists - chemistry Estrogen Antagonists - metabolism Gene Expression Regulation Hormones. Endocrine system Humans In Vitro Techniques Ligands Medical sciences Pharmacology. Drug treatments Phosphorylation Polyunsaturated Alkamides Promoter Regions, Genetic Protein Kinases - metabolism Receptors, Estrogen - metabolism RNA, Messenger - genetics Signal Transduction Structure-Activity Relationship Tamoxifen - pharmacology Transcriptional Activation
Online-Zugang:	Volltext
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