Rapid Substrate Translocation by the Multisubunit, Erythroid Glucose Transporter Requires Subunit Associations but Not Cooperative Ligand Binding

The human erythroid glucose transporter is a GLUT1 homotetramer whose structure and function are stabilized by noncovalent, cooperative subunit interactions. The present study demonstrates that exofacial tryptic digestion of GLUT1 abolishes cooperative interactions between substrate binding sites on...

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