Rapid cytoreduction in childhood leukemic hyperleukocytosis by conservative therapy
Childhood leukemic hyperleukocytosis poses a serious threat to life because of its associated metabolic complications. The present prospective trial utilized conservative management of childhood acute lymphoblastic leukemia with hyperleukocytosis (total white cell count equal or >100 × 109/L) by...
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| Veröffentlicht in: | Medical and pediatric oncology 1995-09, Vol.25 (3), p.204-207 |
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| creator | Basade, Maheboob Dhar, Anil K. Kulkarni, Samar S. Sastry, P. S. R. K. Yadav, Ram P. Parikh, Bhavana S. Pai, Suresh K. Nair, Chandrika N. Kurkure, Purna A. Advani, Suresh H. |
| description | Childhood leukemic hyperleukocytosis poses a serious threat to life because of its associated metabolic complications. The present prospective trial utilized conservative management of childhood acute lymphoblastic leukemia with hyperleukocytosis (total white cell count equal or >100 × 109/L) by intravenous hydration, urinary alkalinization, and allopurinol presenting without severe life‐threatening complications. The median reduction in WBC count was 81.51% (range: 66–98.8%) within a median period of 36 hours (range: 12–60 hours) following hospitalization. There were no failures or treatment related complications. Thus we conclude that in childhood acute lymphoblastic leukemia, hyperleukocytosis can be managed safely and effectively with intravenous hydration, urinary alkalinization, and allopurinol before starting any specific anti‐leukemic chemotherapy avoiding risk‐associated cranial irradiation, leukapheresis, and exchange transfusion. © 1995 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/mpo.2950250308 |
| format | Article |
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S. R. K. ; Yadav, Ram P. ; Parikh, Bhavana S. ; Pai, Suresh K. ; Nair, Chandrika N. ; Kurkure, Purna A. ; Advani, Suresh H.</creator><creatorcontrib>Basade, Maheboob ; Dhar, Anil K. ; Kulkarni, Samar S. ; Sastry, P. S. R. K. ; Yadav, Ram P. ; Parikh, Bhavana S. ; Pai, Suresh K. ; Nair, Chandrika N. ; Kurkure, Purna A. ; Advani, Suresh H.</creatorcontrib><description>Childhood leukemic hyperleukocytosis poses a serious threat to life because of its associated metabolic complications. The present prospective trial utilized conservative management of childhood acute lymphoblastic leukemia with hyperleukocytosis (total white cell count equal or >100 × 109/L) by intravenous hydration, urinary alkalinization, and allopurinol presenting without severe life‐threatening complications. The median reduction in WBC count was 81.51% (range: 66–98.8%) within a median period of 36 hours (range: 12–60 hours) following hospitalization. There were no failures or treatment related complications. Thus we conclude that in childhood acute lymphoblastic leukemia, hyperleukocytosis can be managed safely and effectively with intravenous hydration, urinary alkalinization, and allopurinol before starting any specific anti‐leukemic chemotherapy avoiding risk‐associated cranial irradiation, leukapheresis, and exchange transfusion. © 1995 Wiley‐Liss, Inc.</description><identifier>ISSN: 0098-1532</identifier><identifier>EISSN: 1096-911X</identifier><identifier>DOI: 10.1002/mpo.2950250308</identifier><identifier>PMID: 7623730</identifier><identifier>CODEN: MPONDB</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Allopurinol - therapeutic use ; Biological and medical sciences ; Blood. Blood coagulation. Reticuloendothelial system ; Child ; Child, Preschool ; Citrates - therapeutic use ; Citric Acid ; conservative therapy ; Female ; Fluid Therapy ; Humans ; Hydrogen-Ion Concentration ; hyperleukocytosis ; leukemia ; Leukocyte Count ; Leukocytosis - complications ; Leukocytosis - therapy ; Leukocytosis - urine ; Male ; Medical sciences ; Pharmacology. 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S. R. K.</creatorcontrib><creatorcontrib>Yadav, Ram P.</creatorcontrib><creatorcontrib>Parikh, Bhavana S.</creatorcontrib><creatorcontrib>Pai, Suresh K.</creatorcontrib><creatorcontrib>Nair, Chandrika N.</creatorcontrib><creatorcontrib>Kurkure, Purna A.</creatorcontrib><creatorcontrib>Advani, Suresh H.</creatorcontrib><title>Rapid cytoreduction in childhood leukemic hyperleukocytosis by conservative therapy</title><title>Medical and pediatric oncology</title><addtitle>Med. Pediatr. Oncol</addtitle><description>Childhood leukemic hyperleukocytosis poses a serious threat to life because of its associated metabolic complications. The present prospective trial utilized conservative management of childhood acute lymphoblastic leukemia with hyperleukocytosis (total white cell count equal or >100 × 109/L) by intravenous hydration, urinary alkalinization, and allopurinol presenting without severe life‐threatening complications. The median reduction in WBC count was 81.51% (range: 66–98.8%) within a median period of 36 hours (range: 12–60 hours) following hospitalization. There were no failures or treatment related complications. Thus we conclude that in childhood acute lymphoblastic leukemia, hyperleukocytosis can be managed safely and effectively with intravenous hydration, urinary alkalinization, and allopurinol before starting any specific anti‐leukemic chemotherapy avoiding risk‐associated cranial irradiation, leukapheresis, and exchange transfusion. © 1995 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>Allopurinol - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Citrates - therapeutic use</subject><subject>Citric Acid</subject><subject>conservative therapy</subject><subject>Female</subject><subject>Fluid Therapy</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>hyperleukocytosis</subject><subject>leukemia</subject><subject>Leukocyte Count</subject><subject>Leukocytosis - complications</subject><subject>Leukocytosis - therapy</subject><subject>Leukocytosis - urine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - urine</subject><subject>Prospective Studies</subject><issn>0098-1532</issn><issn>1096-911X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtv1DAUhS0EKtOBLTukLBC7TG3fxI8lGsEU0dJRC4Kd5Ti2xjSJUzsp5N-T0YwGserq6uh-5z4OQm8IXhGM6UXbhxWVJaYlBiyeoQXBkuWSkJ_P0QJjKXJSAn2JzlP6hWctuThDZ5xR4IAX6O5W977OzDSEaOvRDD50me8ys_NNvQuhzho73tvWm2w39TbuVdjTyaesmjITumTjox78o82GnY26n16hF043yb4-1iX6_unjt_VlfnWz-bz-cJWbAnORg3Bcltww6jCAAFFWdSWYEU5KQimXvC5LUTEDRgOAZOAoqV3pCgJGcAdL9P4wt4_hYbRpUK1PxjaN7mwYk-K8IIIWfAZXB9DEkFK0TvXRtzpOimC1T1HNKap_Kc6Gt8fJY9Xa-oQfY5v77459nYxuXNSd8emEAYOCzT8tkTxgv31jpyeWquvtzX8n5AevT4P9c_LqeK8YB16qH183avuluIPNdqPW8BdC_Jry</recordid><startdate>199509</startdate><enddate>199509</enddate><creator>Basade, Maheboob</creator><creator>Dhar, Anil K.</creator><creator>Kulkarni, Samar S.</creator><creator>Sastry, P. S. R. K.</creator><creator>Yadav, Ram P.</creator><creator>Parikh, Bhavana S.</creator><creator>Pai, Suresh K.</creator><creator>Nair, Chandrika N.</creator><creator>Kurkure, Purna A.</creator><creator>Advani, Suresh H.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199509</creationdate><title>Rapid cytoreduction in childhood leukemic hyperleukocytosis by conservative therapy</title><author>Basade, Maheboob ; Dhar, Anil K. ; Kulkarni, Samar S. ; Sastry, P. S. R. K. ; Yadav, Ram P. ; Parikh, Bhavana S. ; Pai, Suresh K. ; Nair, Chandrika N. ; Kurkure, Purna A. ; Advani, Suresh H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4078-38f7957c62f0338385bdb86c8f99122797d558b6c3ca333963f21df5f413c87f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adolescent</topic><topic>Allopurinol - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Citrates - therapeutic use</topic><topic>Citric Acid</topic><topic>conservative therapy</topic><topic>Female</topic><topic>Fluid Therapy</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>hyperleukocytosis</topic><topic>leukemia</topic><topic>Leukocyte Count</topic><topic>Leukocytosis - complications</topic><topic>Leukocytosis - therapy</topic><topic>Leukocytosis - urine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - urine</topic><topic>Prospective Studies</topic><toplevel>online_resources</toplevel><creatorcontrib>Basade, Maheboob</creatorcontrib><creatorcontrib>Dhar, Anil K.</creatorcontrib><creatorcontrib>Kulkarni, Samar S.</creatorcontrib><creatorcontrib>Sastry, P. S. R. 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K.</au><au>Yadav, Ram P.</au><au>Parikh, Bhavana S.</au><au>Pai, Suresh K.</au><au>Nair, Chandrika N.</au><au>Kurkure, Purna A.</au><au>Advani, Suresh H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid cytoreduction in childhood leukemic hyperleukocytosis by conservative therapy</atitle><jtitle>Medical and pediatric oncology</jtitle><addtitle>Med. Pediatr. Oncol</addtitle><date>1995-09</date><risdate>1995</risdate><volume>25</volume><issue>3</issue><spage>204</spage><epage>207</epage><pages>204-207</pages><issn>0098-1532</issn><eissn>1096-911X</eissn><coden>MPONDB</coden><abstract>Childhood leukemic hyperleukocytosis poses a serious threat to life because of its associated metabolic complications. The present prospective trial utilized conservative management of childhood acute lymphoblastic leukemia with hyperleukocytosis (total white cell count equal or >100 × 109/L) by intravenous hydration, urinary alkalinization, and allopurinol presenting without severe life‐threatening complications. The median reduction in WBC count was 81.51% (range: 66–98.8%) within a median period of 36 hours (range: 12–60 hours) following hospitalization. There were no failures or treatment related complications. Thus we conclude that in childhood acute lymphoblastic leukemia, hyperleukocytosis can be managed safely and effectively with intravenous hydration, urinary alkalinization, and allopurinol before starting any specific anti‐leukemic chemotherapy avoiding risk‐associated cranial irradiation, leukapheresis, and exchange transfusion. © 1995 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>7623730</pmid><doi>10.1002/mpo.2950250308</doi><tpages>4</tpages></addata></record> |
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| ispartof | Medical and pediatric oncology, 1995-09, Vol.25 (3), p.204-207 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adolescent Allopurinol - therapeutic use Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Child Child, Preschool Citrates - therapeutic use Citric Acid conservative therapy Female Fluid Therapy Humans Hydrogen-Ion Concentration hyperleukocytosis leukemia Leukocyte Count Leukocytosis - complications Leukocytosis - therapy Leukocytosis - urine Male Medical sciences Pharmacology. Drug treatments Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - urine Prospective Studies |
| title | Rapid cytoreduction in childhood leukemic hyperleukocytosis by conservative therapy |
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