Effects of n-dodecylguanidine on A-type potassium channels: role of external surface charges in channel gating

n-Dodecylguanidine (C12-G) is an amphipathic compound with a guanidine moiety, which is positively charged at physiological pH, and a hydrophobic side chain. Its effects on an A-type K+ channel clone (rKv1.4) expressed in Xenopus oocytes were examined. C12-G caused a concentration-dependent (1-20 mi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular pharmacology 1995-07, Vol.48 (1), p.160-171
Hauptverfasser:	Yao, J A, Saxena, N C, Ziai, M R, Ling, S, Tseng, G N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cations, Divalent Dogs Guanidine Guanidines - pharmacology Heart Ventricles - cytology Heart Ventricles - drug effects Heart Ventricles - metabolism Ion Channel Gating - drug effects Ion Channel Gating - physiology Kinetics Kv1.4 Potassium Channel Membrane Potentials - drug effects Membrane Potentials - physiology Osmolar Concentration Potassium Channels - drug effects Potassium Channels - physiology Potassium Channels, Voltage-Gated Xenopus
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!