Cell type-oriented differential modulatory actions of saikosaponin-d on growth responses and DNA fragmentation of lymphocytes triggered by receptor-mediated and receptor-bypassed pathways

We examined the immunoregulatory action of saikosaponin-d (SSd), which was isolated from the root of Bupleurum talcatum L. and had a steroid-like structure, on murine thymocytes, and compared the action with that on spleen cells. Constitutive DNA synthesis or the growth response stimulated with anti...

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Veröffentlicht in:	Immunopharmacology 1995-04, Vol.29 (3), p.207-213
Hauptverfasser:	Kato, Masashi, Pu, Mei-yi, Isobe, Ken-Ichi, Hattori, Taku, Yanagita, Noriyuki, Nakashima, Izumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Biological and medical sciences Calcimycin - pharmacology Cell Division - drug effects Cells, Cultured DNA Damage - immunology Down-Regulation General pharmacology Immuno-regulation Interleukin-2 - biosynthesis Interleukin-2 - genetics Interleukin-4 - biosynthesis Interleukin-4 - genetics Lymphocyte Activation - drug effects Lymphocyte Activation - genetics Lymphocyte Activation - immunology Medical sciences Mice Mice, Inbred C57BL Oleanolic Acid - analogs & derivatives Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Receptor-bypassed pathway Receptor-mediated pathway Receptors, Immunologic - drug effects Receptors, Immunologic - genetics Receptors, Immunologic - immunology Saikosaponin-d Sapogenins - pharmacology Saponins Signal Transduction - drug effects Signal Transduction - genetics Signal Transduction - immunology Spleen - cytology Spleen - drug effects Spleen - immunology T-Lymphocytes - drug effects T-Lymphocytes - immunology Thymus Gland - cytology Up-Regulation
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