Acute lymphoblastic leukemia with chromosomal 5;14 translocation and hypereosinophilia: case report and literature review
A 19-year-old man with acute lymphoblastic leukemia (ALL) presented with 82,000 WBC/microL, 57% eosinophils, and cardiorespiratory symptoms. Lymphoblast infiltration of the meninges and testes developed without eosinophil infiltration at these sites and peripheral blood and marrow lymphoblast counts...
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| Veröffentlicht in: | Journal of clinical oncology 1987-03, Vol.5 (3), p.382-390 |
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| container_end_page | 390 |
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| container_issue | 3 |
| container_start_page | 382 |
| container_title | Journal of clinical oncology |
| container_volume | 5 |
| creator | Hogan, T F Koss, W Murgo, A J Amato, R S Fontana, J A VanScoy, F L |
| description | A 19-year-old man with acute lymphoblastic leukemia (ALL) presented with 82,000 WBC/microL, 57% eosinophils, and cardiorespiratory symptoms. Lymphoblast infiltration of the meninges and testes developed without eosinophil infiltration at these sites and peripheral blood and marrow lymphoblast counts progressively increased, while blood eosinophilia disappeared. The patient's bone marrow cells had a clonal cytogenetic abnormality--t(5;14), (q?,q32)--which disappeared during remission and reappeared during disease relapse. Including this case, three patients with ALL and hypereosinophilia have had cytogenetic studies with G-banding. All three had 14q + chromosomal abnormalities and two had a similar translocation t(5,14), (q?,q32). Survival of the 26 ALL patients with hypereosinophilia reported since 1973 was similar to that of 52 age- and sex-matched historical-control patients without hypereosinophilia treated during the same time interval. |
| doi_str_mv | 10.1200/JCO.1987.5.3.382 |
| format | Article |
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Lymphoblast infiltration of the meninges and testes developed without eosinophil infiltration at these sites and peripheral blood and marrow lymphoblast counts progressively increased, while blood eosinophilia disappeared. The patient's bone marrow cells had a clonal cytogenetic abnormality--t(5;14), (q?,q32)--which disappeared during remission and reappeared during disease relapse. Including this case, three patients with ALL and hypereosinophilia have had cytogenetic studies with G-banding. All three had 14q + chromosomal abnormalities and two had a similar translocation t(5,14), (q?,q32). Survival of the 26 ALL patients with hypereosinophilia reported since 1973 was similar to that of 52 age- and sex-matched historical-control patients without hypereosinophilia treated during the same time interval.</description><identifier>ISSN: 0732-183X</identifier><identifier>EISSN: 1527-7755</identifier><identifier>DOI: 10.1200/JCO.1987.5.3.382</identifier><identifier>PMID: 3546615</identifier><language>eng</language><publisher>United States: American Society of Clinical Oncology</publisher><subject>Actuarial Analysis ; Adolescent ; Adult ; Blood Cell Count ; Bone Marrow - ultrastructure ; Child ; Child, Preschool ; Chromosome Banding ; Eosinophilia - etiology ; Female ; Humans ; Leukemia, Lymphoid - blood ; Leukemia, Lymphoid - complications ; Leukemia, Lymphoid - genetics ; Male ; Translocation, Genetic</subject><ispartof>Journal of clinical oncology, 1987-03, Vol.5 (3), p.382-390</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c323t-12d91b21dd33a9b1c001089ece11e3666be9af20b3200650c062ecbe6663336f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3729,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3546615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hogan, T F</creatorcontrib><creatorcontrib>Koss, W</creatorcontrib><creatorcontrib>Murgo, A J</creatorcontrib><creatorcontrib>Amato, R S</creatorcontrib><creatorcontrib>Fontana, J A</creatorcontrib><creatorcontrib>VanScoy, F L</creatorcontrib><title>Acute lymphoblastic leukemia with chromosomal 5;14 translocation and hypereosinophilia: case report and literature review</title><title>Journal of clinical oncology</title><addtitle>J Clin Oncol</addtitle><description>A 19-year-old man with acute lymphoblastic leukemia (ALL) presented with 82,000 WBC/microL, 57% eosinophils, and cardiorespiratory symptoms. Lymphoblast infiltration of the meninges and testes developed without eosinophil infiltration at these sites and peripheral blood and marrow lymphoblast counts progressively increased, while blood eosinophilia disappeared. The patient's bone marrow cells had a clonal cytogenetic abnormality--t(5;14), (q?,q32)--which disappeared during remission and reappeared during disease relapse. Including this case, three patients with ALL and hypereosinophilia have had cytogenetic studies with G-banding. All three had 14q + chromosomal abnormalities and two had a similar translocation t(5,14), (q?,q32). Survival of the 26 ALL patients with hypereosinophilia reported since 1973 was similar to that of 52 age- and sex-matched historical-control patients without hypereosinophilia treated during the same time interval.</description><subject>Actuarial Analysis</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Blood Cell Count</subject><subject>Bone Marrow - ultrastructure</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chromosome Banding</subject><subject>Eosinophilia - etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Leukemia, Lymphoid - blood</subject><subject>Leukemia, Lymphoid - complications</subject><subject>Leukemia, Lymphoid - genetics</subject><subject>Male</subject><subject>Translocation, Genetic</subject><issn>0732-183X</issn><issn>1527-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1r3DAQhkVoSbZp7rkUdCi52ZU0K3-0p7CkXwRyaSE3IcuztVLZciU5y_77arPbngbmfeaFeQi55qzkgrEP3zcPJW-bupQllNCIM7LiUtRFXUv5iqxYDaLgDTxekDcxPjHG1w3Ic3IOcl1VXK7I_tYsCanbj_PgO6djsoY6XH7jaDXd2TRQMwQ_-uhH7aj8xNc0BT1F541O1k9UTz0d9jMG9NFOfh6ss_ojNToiDTj7kF4QZxMGnZZw2D5b3L0lr7faRbw6zUvy8_Pdj83X4v7hy7fN7X1hQEAquOhb3gne9wC67bjJT7CmRYOcI1RV1WGrt4J1kH1UkhlWCTQd5gQAqi1ckptj7xz8nwVjUqONBp3TE_olqrpeZysSMsiOoAk-xoBbNQc76rBXnKmDbZVtq4NtJRWobDufvDt1L92I_f-Dk96cvz_mg_017GxAFbNFl2mhnoz_V_MXpt-Jjg</recordid><startdate>19870301</startdate><enddate>19870301</enddate><creator>Hogan, T F</creator><creator>Koss, W</creator><creator>Murgo, A J</creator><creator>Amato, R S</creator><creator>Fontana, J A</creator><creator>VanScoy, F L</creator><general>American Society of Clinical Oncology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870301</creationdate><title>Acute lymphoblastic leukemia with chromosomal 5;14 translocation and hypereosinophilia: case report and literature review</title><author>Hogan, T F ; Koss, W ; Murgo, A J ; Amato, R S ; Fontana, J A ; VanScoy, F L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-12d91b21dd33a9b1c001089ece11e3666be9af20b3200650c062ecbe6663336f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Actuarial Analysis</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Blood Cell Count</topic><topic>Bone Marrow - ultrastructure</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chromosome Banding</topic><topic>Eosinophilia - etiology</topic><topic>Female</topic><topic>Humans</topic><topic>Leukemia, Lymphoid - blood</topic><topic>Leukemia, Lymphoid - complications</topic><topic>Leukemia, Lymphoid - genetics</topic><topic>Male</topic><topic>Translocation, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hogan, T F</creatorcontrib><creatorcontrib>Koss, W</creatorcontrib><creatorcontrib>Murgo, A J</creatorcontrib><creatorcontrib>Amato, R S</creatorcontrib><creatorcontrib>Fontana, J A</creatorcontrib><creatorcontrib>VanScoy, F L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hogan, T F</au><au>Koss, W</au><au>Murgo, A J</au><au>Amato, R S</au><au>Fontana, J A</au><au>VanScoy, F L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute lymphoblastic leukemia with chromosomal 5;14 translocation and hypereosinophilia: case report and literature review</atitle><jtitle>Journal of clinical oncology</jtitle><addtitle>J Clin Oncol</addtitle><date>1987-03-01</date><risdate>1987</risdate><volume>5</volume><issue>3</issue><spage>382</spage><epage>390</epage><pages>382-390</pages><issn>0732-183X</issn><eissn>1527-7755</eissn><abstract>A 19-year-old man with acute lymphoblastic leukemia (ALL) presented with 82,000 WBC/microL, 57% eosinophils, and cardiorespiratory symptoms. Lymphoblast infiltration of the meninges and testes developed without eosinophil infiltration at these sites and peripheral blood and marrow lymphoblast counts progressively increased, while blood eosinophilia disappeared. The patient's bone marrow cells had a clonal cytogenetic abnormality--t(5;14), (q?,q32)--which disappeared during remission and reappeared during disease relapse. Including this case, three patients with ALL and hypereosinophilia have had cytogenetic studies with G-banding. All three had 14q + chromosomal abnormalities and two had a similar translocation t(5,14), (q?,q32). Survival of the 26 ALL patients with hypereosinophilia reported since 1973 was similar to that of 52 age- and sex-matched historical-control patients without hypereosinophilia treated during the same time interval.</abstract><cop>United States</cop><pub>American Society of Clinical Oncology</pub><pmid>3546615</pmid><doi>10.1200/JCO.1987.5.3.382</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0732-183X |
| ispartof | Journal of clinical oncology, 1987-03, Vol.5 (3), p.382-390 |
| issn | 0732-183X 1527-7755 |
| language | eng |
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| source | MEDLINE; American Society of Clinical Oncology; Journals@Ovid Complete |
| subjects | Actuarial Analysis Adolescent Adult Blood Cell Count Bone Marrow - ultrastructure Child Child, Preschool Chromosome Banding Eosinophilia - etiology Female Humans Leukemia, Lymphoid - blood Leukemia, Lymphoid - complications Leukemia, Lymphoid - genetics Male Translocation, Genetic |
| title | Acute lymphoblastic leukemia with chromosomal 5;14 translocation and hypereosinophilia: case report and literature review |
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