The metabotropic glutamate receptors: Structure and functions
Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels—termed NMDA, AMPA and kainate receptors—involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate ion channe...
Gespeichert in:
| Veröffentlicht in: | Neuropharmacology 1995, Vol.34 (1), p.1-26 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 26 |
|---|---|
| container_issue | 1 |
| container_start_page | 1 |
| container_title | Neuropharmacology |
| container_volume | 34 |
| creator | Pin, J.-P. Duvoisin, R. |
| description | Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels—termed NMDA, AMPA and kainate receptors—involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins. The existence of these receptors, called metabotropic glutamate receptors, is changing our views on the functioning of fast excitatory synapses. |
| doi_str_mv | 10.1016/0028-3908(94)00129-G |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77414599</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>002839089400129G</els_id><sourcerecordid>16793415</sourcerecordid><originalsourceid>FETCH-LOGICAL-c534t-90382ec2ce8f4d81c98bac5bb5fcb28393d445ebcdca1f5610a024e0edc7e26d3</originalsourceid><addsrcrecordid>eNqFkEuLFDEUhYMoY8_oP1CohYguSm8eVUkEBRmcHmHAheM6pG5uaaQebZIa8N9bPd30clzdxfnO4fIx9oLDOw68fQ8gTC0tmDdWvQXgwtbbR2zDjZa1hlY9ZpsT8pSd5_wbAJTh5oyd6VZI2-gN-3j7i6qRiu_mkuZdxOrnsBQ_-kJVIqRdmVP-UH0vacGyJKr8FKp-mbDEecrP2JPeD5meH-8F-3H15fbyur75tv16-fmmxkaqUluQRhAKJNOrYDha03lsuq7psRNGWhmUaqjDgJ73TcvBg1AEFFCTaIO8YK8Pu7s0_1koFzfGjDQMfqJ5yU5rxVVj7X9B3morFW9WUB1ATHPOiXq3S3H06a_j4PZ63d6d27tzVrl7vW671l4e95dupHAqHX2u-atj7jP6oU9-wphPmFRKSxAr9umA0SrtLlJyGSNNSCGu0osLc3z4j3_Te5bM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16793415</pqid></control><display><type>article</type><title>The metabotropic glutamate receptors: Structure and functions</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Pin, J.-P. ; Duvoisin, R.</creator><creatorcontrib>Pin, J.-P. ; Duvoisin, R.</creatorcontrib><description>Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels—termed NMDA, AMPA and kainate receptors—involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins. The existence of these receptors, called metabotropic glutamate receptors, is changing our views on the functioning of fast excitatory synapses.</description><identifier>ISSN: 0028-3908</identifier><identifier>EISSN: 1873-7064</identifier><identifier>DOI: 10.1016/0028-3908(94)00129-G</identifier><identifier>PMID: 7623957</identifier><identifier>CODEN: NEPHBW</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>ACPD ; adenylyl cyclase ; alternative splicing ; Aminoacid receptors (glycine, glutamate, gaba) ; Animals ; Base Sequence ; Binding Sites ; Biological and medical sciences ; Ca 2+-channels ; Calcium Channels ; Cell receptors ; Cell structures and functions ; cloning ; Cloning, Molecular ; Cyclic GMP ; Fundamental and applied biological sciences. Psychology ; G-protein ; glutamate ; Glutamic Acid - pharmacology ; GTP-Binding Proteins ; Humans ; K +-channels ; LTD ; LTP ; mGluR ; Molecular and cellular biology ; Molecular Sequence Data ; Neurotransmitter Agents - chemistry ; Neurotransmitter Agents - physiology ; PLC ; Receptors, Metabotropic Glutamate - chemistry ; Receptors, Metabotropic Glutamate - genetics ; Receptors, Metabotropic Glutamate - physiology</subject><ispartof>Neuropharmacology, 1995, Vol.34 (1), p.1-26</ispartof><rights>1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-90382ec2ce8f4d81c98bac5bb5fcb28393d445ebcdca1f5610a024e0edc7e26d3</citedby><cites>FETCH-LOGICAL-c534t-90382ec2ce8f4d81c98bac5bb5fcb28393d445ebcdca1f5610a024e0edc7e26d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0028-3908(94)00129-G$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>313,314,780,784,792,3550,4024,4054,27922,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3447302$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7623957$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pin, J.-P.</creatorcontrib><creatorcontrib>Duvoisin, R.</creatorcontrib><title>The metabotropic glutamate receptors: Structure and functions</title><title>Neuropharmacology</title><addtitle>Neuropharmacology</addtitle><description>Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels—termed NMDA, AMPA and kainate receptors—involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins. The existence of these receptors, called metabotropic glutamate receptors, is changing our views on the functioning of fast excitatory synapses.</description><subject>ACPD</subject><subject>adenylyl cyclase</subject><subject>alternative splicing</subject><subject>Aminoacid receptors (glycine, glutamate, gaba)</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>Ca 2+-channels</subject><subject>Calcium Channels</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>cloning</subject><subject>Cloning, Molecular</subject><subject>Cyclic GMP</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>G-protein</subject><subject>glutamate</subject><subject>Glutamic Acid - pharmacology</subject><subject>GTP-Binding Proteins</subject><subject>Humans</subject><subject>K +-channels</subject><subject>LTD</subject><subject>LTP</subject><subject>mGluR</subject><subject>Molecular and cellular biology</subject><subject>Molecular Sequence Data</subject><subject>Neurotransmitter Agents - chemistry</subject><subject>Neurotransmitter Agents - physiology</subject><subject>PLC</subject><subject>Receptors, Metabotropic Glutamate - chemistry</subject><subject>Receptors, Metabotropic Glutamate - genetics</subject><subject>Receptors, Metabotropic Glutamate - physiology</subject><issn>0028-3908</issn><issn>1873-7064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEuLFDEUhYMoY8_oP1CohYguSm8eVUkEBRmcHmHAheM6pG5uaaQebZIa8N9bPd30clzdxfnO4fIx9oLDOw68fQ8gTC0tmDdWvQXgwtbbR2zDjZa1hlY9ZpsT8pSd5_wbAJTh5oyd6VZI2-gN-3j7i6qRiu_mkuZdxOrnsBQ_-kJVIqRdmVP-UH0vacGyJKr8FKp-mbDEecrP2JPeD5meH-8F-3H15fbyur75tv16-fmmxkaqUluQRhAKJNOrYDha03lsuq7psRNGWhmUaqjDgJ73TcvBg1AEFFCTaIO8YK8Pu7s0_1koFzfGjDQMfqJ5yU5rxVVj7X9B3morFW9WUB1ATHPOiXq3S3H06a_j4PZ63d6d27tzVrl7vW671l4e95dupHAqHX2u-atj7jP6oU9-wphPmFRKSxAr9umA0SrtLlJyGSNNSCGu0osLc3z4j3_Te5bM</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Pin, J.-P.</creator><creator>Duvoisin, R.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>The metabotropic glutamate receptors: Structure and functions</title><author>Pin, J.-P. ; Duvoisin, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-90382ec2ce8f4d81c98bac5bb5fcb28393d445ebcdca1f5610a024e0edc7e26d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>ACPD</topic><topic>adenylyl cyclase</topic><topic>alternative splicing</topic><topic>Aminoacid receptors (glycine, glutamate, gaba)</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Binding Sites</topic><topic>Biological and medical sciences</topic><topic>Ca 2+-channels</topic><topic>Calcium Channels</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>cloning</topic><topic>Cloning, Molecular</topic><topic>Cyclic GMP</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>G-protein</topic><topic>glutamate</topic><topic>Glutamic Acid - pharmacology</topic><topic>GTP-Binding Proteins</topic><topic>Humans</topic><topic>K +-channels</topic><topic>LTD</topic><topic>LTP</topic><topic>mGluR</topic><topic>Molecular and cellular biology</topic><topic>Molecular Sequence Data</topic><topic>Neurotransmitter Agents - chemistry</topic><topic>Neurotransmitter Agents - physiology</topic><topic>PLC</topic><topic>Receptors, Metabotropic Glutamate - chemistry</topic><topic>Receptors, Metabotropic Glutamate - genetics</topic><topic>Receptors, Metabotropic Glutamate - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pin, J.-P.</creatorcontrib><creatorcontrib>Duvoisin, R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pin, J.-P.</au><au>Duvoisin, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The metabotropic glutamate receptors: Structure and functions</atitle><jtitle>Neuropharmacology</jtitle><addtitle>Neuropharmacology</addtitle><date>1995</date><risdate>1995</risdate><volume>34</volume><issue>1</issue><spage>1</spage><epage>26</epage><pages>1-26</pages><issn>0028-3908</issn><eissn>1873-7064</eissn><coden>NEPHBW</coden><abstract>Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels—termed NMDA, AMPA and kainate receptors—involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins. The existence of these receptors, called metabotropic glutamate receptors, is changing our views on the functioning of fast excitatory synapses.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>7623957</pmid><doi>10.1016/0028-3908(94)00129-G</doi><tpages>26</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-3908 |
| ispartof | Neuropharmacology, 1995, Vol.34 (1), p.1-26 |
| issn | 0028-3908 1873-7064 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77414599 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | ACPD adenylyl cyclase alternative splicing Aminoacid receptors (glycine, glutamate, gaba) Animals Base Sequence Binding Sites Biological and medical sciences Ca 2+-channels Calcium Channels Cell receptors Cell structures and functions cloning Cloning, Molecular Cyclic GMP Fundamental and applied biological sciences. Psychology G-protein glutamate Glutamic Acid - pharmacology GTP-Binding Proteins Humans K +-channels LTD LTP mGluR Molecular and cellular biology Molecular Sequence Data Neurotransmitter Agents - chemistry Neurotransmitter Agents - physiology PLC Receptors, Metabotropic Glutamate - chemistry Receptors, Metabotropic Glutamate - genetics Receptors, Metabotropic Glutamate - physiology |
| title | The metabotropic glutamate receptors: Structure and functions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T17%3A10%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20metabotropic%20glutamate%20receptors:%20Structure%20and%20functions&rft.jtitle=Neuropharmacology&rft.au=Pin,%20J.-P.&rft.date=1995&rft.volume=34&rft.issue=1&rft.spage=1&rft.epage=26&rft.pages=1-26&rft.issn=0028-3908&rft.eissn=1873-7064&rft.coden=NEPHBW&rft_id=info:doi/10.1016/0028-3908(94)00129-G&rft_dat=%3Cproquest_cross%3E16793415%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16793415&rft_id=info:pmid/7623957&rft_els_id=002839089400129G&rfr_iscdi=true |