Caffeine increases its own metabolism through cytochrome P4501A induction in rats
Caffeine is one of the most widely used - and may be abused - xenobiotic compounds in the world. If numerous pharmacological properties of caffeine have been reported, the effects of caffeine treatment on the hepatic drug-metabolizing enzyme system have been scarcely studied. Pretreatment of rats fo...
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| Veröffentlicht in: | Life sciences (1973) 1995, Vol.57 (6), p.541-549 |
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| container_title | Life sciences (1973) |
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| creator | Berthou, François Goasduff, Thierry Dréano, Yvonne Ménez, Jean-François |
| description | Caffeine is one of the most widely used - and may be abused - xenobiotic compounds in the world. If numerous pharmacological properties of caffeine have been reported, the effects of caffeine treatment on the hepatic drug-metabolizing enzyme system have been scarcely studied. Pretreatment of rats for 3 days with 150 mg/kg/day of caffeine dramatically increased P4501A and P4502B dependent catalytic activities determined
in vitro. Furthermore,
N-demethylations and C-8 oxidation of caffeine were increased by about 2 fold by caffeine treatment. Immunoblot analysis demonstrated that the liver contents of P4501A2 and P4502B1/2B2, known to be involved in these monooxygenase activities, increased also by about 2 fold. Cytochrome P4503A1 and 2E1 were not modified. Taken together, there data suggest that caffeine increases its own metabolism through P4501A induction. |
| doi_str_mv | 10.1016/0024-3205(95)00304-O |
| format | Article |
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in vitro. Furthermore,
N-demethylations and C-8 oxidation of caffeine were increased by about 2 fold by caffeine treatment. Immunoblot analysis demonstrated that the liver contents of P4501A2 and P4502B1/2B2, known to be involved in these monooxygenase activities, increased also by about 2 fold. Cytochrome P4503A1 and 2E1 were not modified. Taken together, there data suggest that caffeine increases its own metabolism through P4501A induction.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(95)00304-O</identifier><identifier>PMID: 7623622</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Caffeine - metabolism ; Caffeine - pharmacology ; caffeine demethylations ; caffeine induction ; CYP1A ; CYP2B ; Cytochrome P-450 Enzyme System - drug effects ; Cytochrome P-450 Enzyme System - metabolism ; cytochrome P450 ; Enzyme Induction - drug effects ; Immunoblotting ; Male ; Microsomes, Liver - drug effects ; Microsomes, Liver - metabolism ; Oxygenases - metabolism ; Rats ; Rats, Wistar</subject><ispartof>Life sciences (1973), 1995, Vol.57 (6), p.541-549</ispartof><rights>1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-83d7b4c4ed3026ab0e87c5b5362a1eccebc644cc504f22e3288450be30af81ed3</citedby><cites>FETCH-LOGICAL-c388t-83d7b4c4ed3026ab0e87c5b5362a1eccebc644cc504f22e3288450be30af81ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/002432059500304O$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7623622$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berthou, François</creatorcontrib><creatorcontrib>Goasduff, Thierry</creatorcontrib><creatorcontrib>Dréano, Yvonne</creatorcontrib><creatorcontrib>Ménez, Jean-François</creatorcontrib><title>Caffeine increases its own metabolism through cytochrome P4501A induction in rats</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Caffeine is one of the most widely used - and may be abused - xenobiotic compounds in the world. If numerous pharmacological properties of caffeine have been reported, the effects of caffeine treatment on the hepatic drug-metabolizing enzyme system have been scarcely studied. Pretreatment of rats for 3 days with 150 mg/kg/day of caffeine dramatically increased P4501A and P4502B dependent catalytic activities determined
in vitro. Furthermore,
N-demethylations and C-8 oxidation of caffeine were increased by about 2 fold by caffeine treatment. Immunoblot analysis demonstrated that the liver contents of P4501A2 and P4502B1/2B2, known to be involved in these monooxygenase activities, increased also by about 2 fold. Cytochrome P4503A1 and 2E1 were not modified. Taken together, there data suggest that caffeine increases its own metabolism through P4501A induction.</description><subject>Animals</subject><subject>Caffeine - metabolism</subject><subject>Caffeine - pharmacology</subject><subject>caffeine demethylations</subject><subject>caffeine induction</subject><subject>CYP1A</subject><subject>CYP2B</subject><subject>Cytochrome P-450 Enzyme System - drug effects</subject><subject>Cytochrome P-450 Enzyme System - metabolism</subject><subject>cytochrome P450</subject><subject>Enzyme Induction - drug effects</subject><subject>Immunoblotting</subject><subject>Male</subject><subject>Microsomes, Liver - drug effects</subject><subject>Microsomes, Liver - metabolism</subject><subject>Oxygenases - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9r20AQxZeS4jppvkEDOoXmoGb2nyRfAsY0ScHgFJrzshqNmg2WNt1dNeTbd12bHJPTDLz35g0_xr5w-MaBV5cAQpVSgP660BcAElS5-cDmvKkXJVSSH7H5q-UTO47xEQC0ruWMzepKyEqIOfu5sn1PbqTCjRjIRoqFS7Hwz2MxULKt37o4FOkh-On3Q4EvyWPeByrulAa-zLFuwuT8mLci2BQ_s4-93UY6PcwTdn_9_dfqtlxvbn6slusSZdOkspFd3SpU1EkQlW2Bmhp1q_NblhMitVgphahB9UKQFE2TC1uSYPuG59QJO9_ffQr-z0QxmcFFpO3WjuSnaOpaccFl9a6R60WmwmU2qr0Rg48xUG-eghtseDEczA652fE0O55moc1_5GaTY2eH-1M7UPcaOjDO-tVep0zjr6NgIjoakToXCJPpvHu74B8oXo-1</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Berthou, François</creator><creator>Goasduff, Thierry</creator><creator>Dréano, Yvonne</creator><creator>Ménez, Jean-François</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>Caffeine increases its own metabolism through cytochrome P4501A induction in rats</title><author>Berthou, François ; Goasduff, Thierry ; Dréano, Yvonne ; Ménez, Jean-François</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-83d7b4c4ed3026ab0e87c5b5362a1eccebc644cc504f22e3288450be30af81ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Caffeine - metabolism</topic><topic>Caffeine - pharmacology</topic><topic>caffeine demethylations</topic><topic>caffeine induction</topic><topic>CYP1A</topic><topic>CYP2B</topic><topic>Cytochrome P-450 Enzyme System - drug effects</topic><topic>Cytochrome P-450 Enzyme System - metabolism</topic><topic>cytochrome P450</topic><topic>Enzyme Induction - drug effects</topic><topic>Immunoblotting</topic><topic>Male</topic><topic>Microsomes, Liver - drug effects</topic><topic>Microsomes, Liver - metabolism</topic><topic>Oxygenases - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berthou, François</creatorcontrib><creatorcontrib>Goasduff, Thierry</creatorcontrib><creatorcontrib>Dréano, Yvonne</creatorcontrib><creatorcontrib>Ménez, Jean-François</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berthou, François</au><au>Goasduff, Thierry</au><au>Dréano, Yvonne</au><au>Ménez, Jean-François</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Caffeine increases its own metabolism through cytochrome P4501A induction in rats</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1995</date><risdate>1995</risdate><volume>57</volume><issue>6</issue><spage>541</spage><epage>549</epage><pages>541-549</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Caffeine is one of the most widely used - and may be abused - xenobiotic compounds in the world. If numerous pharmacological properties of caffeine have been reported, the effects of caffeine treatment on the hepatic drug-metabolizing enzyme system have been scarcely studied. Pretreatment of rats for 3 days with 150 mg/kg/day of caffeine dramatically increased P4501A and P4502B dependent catalytic activities determined
in vitro. Furthermore,
N-demethylations and C-8 oxidation of caffeine were increased by about 2 fold by caffeine treatment. Immunoblot analysis demonstrated that the liver contents of P4501A2 and P4502B1/2B2, known to be involved in these monooxygenase activities, increased also by about 2 fold. Cytochrome P4503A1 and 2E1 were not modified. Taken together, there data suggest that caffeine increases its own metabolism through P4501A induction.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>7623622</pmid><doi>10.1016/0024-3205(95)00304-O</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Life sciences (1973), 1995, Vol.57 (6), p.541-549 |
| issn | 0024-3205 1879-0631 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Caffeine - metabolism Caffeine - pharmacology caffeine demethylations caffeine induction CYP1A CYP2B Cytochrome P-450 Enzyme System - drug effects Cytochrome P-450 Enzyme System - metabolism cytochrome P450 Enzyme Induction - drug effects Immunoblotting Male Microsomes, Liver - drug effects Microsomes, Liver - metabolism Oxygenases - metabolism Rats Rats, Wistar |
| title | Caffeine increases its own metabolism through cytochrome P4501A induction in rats |
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