Effect of Isoproterenol on Accessory Pathways Without Overt Retrograde Conduction
Effect of Isoproterenol on Accessory Pathways. Introduction: Absence of overt retrograde accessory pathway conduction may be related to low resting sympathetic tone in patients with apparent unidirectional anterogradely conducting accessory pathways (UACAP). Methods and Results: To test this hypothe...
Gespeichert in:
Veröffentlicht in: | Journal of cardiovascular electrophysiology 1995-03, Vol.6 (3), p.170-173 |
---|---|
Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 173 |
---|---|
container_issue | 3 |
container_start_page | 170 |
container_title | Journal of cardiovascular electrophysiology |
container_volume | 6 |
creator | LI, HUAGUI G. YEE, RAYMOND KLEIN, GEORGE J. |
description | Effect of Isoproterenol on Accessory Pathways. Introduction: Absence of overt retrograde accessory pathway conduction may be related to low resting sympathetic tone in patients with apparent unidirectional anterogradely conducting accessory pathways (UACAP).
Methods and Results: To test this hypothesis, we studied the effect of isoproterenol on accessory pathway function and tachycardia induction in 18 patients (12 men and 6 women, ages 34 ± 16 years [mean ± SD]) with UACAP. After baseline study in the drug‐free state, electrophysiologic testing was repeated during infusion of isoproterenol (0.5 to 1.5 μg/min, titrated to increase heart rate by 20%). Isoproterenol shortened the anterograde effective refractory period (398 ± 117 vs 305 ± 63 msec; P < 0.01; basic drive cycle length 600 msec) of the accessory pathway. However, retrograde accessory pathway conduction and atrioventricular reentrant tachycardia were exposed in only 3 (17%) patients by isoproterenol infusion. All 3 patients with retrograde accessory pathway revealed after isoproterenol had clinically documented tachycardia (supraventricular tachycardia in 2, atrial fibrillation in 1) during exercise, while none of the patients with persistent absence of retrograde accessory pathway conduction had this symptom.
Conclusions: We conclude that absence of overt retrograde conduction over accessory pathways may be related to low resting sympathetic tone in some individuals. Restoration of retrograde conduction with isoproterenol is unusual and most likely to be observed in patients with clinically documented paroxysmal supraventricular tachycardia related to exercise. |
doi_str_mv | 10.1111/j.1540-8167.1995.tb00768.x |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77410451</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77410451</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4730-6cf5625c9227bf287b4fd568c758451dddd1d7bc1dc569a30d29f3baba0399353</originalsourceid><addsrcrecordid>eNqVkF1PwyAUhonR-DH9CSbEC-9aoRRovTAxy_xcnBrNEm8IpaCdXVGguv1722zZvecGkvec58ADwAlGMe7qbBZjmqIow4zHOM9pHAqEOMvixRbY30Tb3R2lNCIZJ3vgwPsZQpgwRHfBLmcJYmmyD55GxmgVoDXw1tsvZ4N2urE1tA28VEp7b90SPsrw8SuXHk6r8GHbACc_2gX4rIOz706WGg5tU7YqVLY5BDtG1l4frc8BeL0avQxvovHk-nZ4OY5UygmKmDKUJVTlScILk2S8SE1JWaY4zVKKy65wyQuFS0VZLgkqk9yQQhYSkTwnlAzA6YrbPfq71T6IeeWVrmvZaNt6wXnafx93jeerRuWs904b8eWquXRLgZHofYqZ6KWJXprofYq1T7Hoho_XW9pirsvN6Fpgl1-s8t-q1st_kMXdcIQ56gDRClD5oBcbgHSfgnHCqZg-XIv79IlPp9mbGJM_uHqVbQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77410451</pqid></control><display><type>article</type><title>Effect of Isoproterenol on Accessory Pathways Without Overt Retrograde Conduction</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>LI, HUAGUI G. ; YEE, RAYMOND ; KLEIN, GEORGE J.</creator><creatorcontrib>LI, HUAGUI G. ; YEE, RAYMOND ; KLEIN, GEORGE J.</creatorcontrib><description>Effect of Isoproterenol on Accessory Pathways. Introduction: Absence of overt retrograde accessory pathway conduction may be related to low resting sympathetic tone in patients with apparent unidirectional anterogradely conducting accessory pathways (UACAP).
Methods and Results: To test this hypothesis, we studied the effect of isoproterenol on accessory pathway function and tachycardia induction in 18 patients (12 men and 6 women, ages 34 ± 16 years [mean ± SD]) with UACAP. After baseline study in the drug‐free state, electrophysiologic testing was repeated during infusion of isoproterenol (0.5 to 1.5 μg/min, titrated to increase heart rate by 20%). Isoproterenol shortened the anterograde effective refractory period (398 ± 117 vs 305 ± 63 msec; P < 0.01; basic drive cycle length 600 msec) of the accessory pathway. However, retrograde accessory pathway conduction and atrioventricular reentrant tachycardia were exposed in only 3 (17%) patients by isoproterenol infusion. All 3 patients with retrograde accessory pathway revealed after isoproterenol had clinically documented tachycardia (supraventricular tachycardia in 2, atrial fibrillation in 1) during exercise, while none of the patients with persistent absence of retrograde accessory pathway conduction had this symptom.
Conclusions: We conclude that absence of overt retrograde conduction over accessory pathways may be related to low resting sympathetic tone in some individuals. Restoration of retrograde conduction with isoproterenol is unusual and most likely to be observed in patients with clinically documented paroxysmal supraventricular tachycardia related to exercise.</description><identifier>ISSN: 1045-3873</identifier><identifier>EISSN: 1540-8167</identifier><identifier>DOI: 10.1111/j.1540-8167.1995.tb00768.x</identifier><identifier>PMID: 7620642</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Accessory Nerve - drug effects ; Accessory Nerve - physiology ; Adolescent ; Adult ; Aged ; Atrioventricular Node - physiology ; Bundle of His - physiology ; Electrocardiography ; Exercise - physiology ; Female ; Humans ; isoproterenol ; Isoproterenol - pharmacology ; Male ; Middle Aged ; Neural Conduction - drug effects ; Neural Conduction - physiology ; retrograde accessory pathway conduction ; Retrograde Degeneration - physiology ; Tachycardia - physiopathology ; Tachycardia, Atrioventricular Nodal Reentry - physiopathology ; Tachycardia, Ventricular - physiopathology</subject><ispartof>Journal of cardiovascular electrophysiology, 1995-03, Vol.6 (3), p.170-173</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4730-6cf5625c9227bf287b4fd568c758451dddd1d7bc1dc569a30d29f3baba0399353</citedby><cites>FETCH-LOGICAL-c4730-6cf5625c9227bf287b4fd568c758451dddd1d7bc1dc569a30d29f3baba0399353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1540-8167.1995.tb00768.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1540-8167.1995.tb00768.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27926,27927,45576,45577</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7620642$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LI, HUAGUI G.</creatorcontrib><creatorcontrib>YEE, RAYMOND</creatorcontrib><creatorcontrib>KLEIN, GEORGE J.</creatorcontrib><title>Effect of Isoproterenol on Accessory Pathways Without Overt Retrograde Conduction</title><title>Journal of cardiovascular electrophysiology</title><addtitle>J Cardiovasc Electrophysiol</addtitle><description>Effect of Isoproterenol on Accessory Pathways. Introduction: Absence of overt retrograde accessory pathway conduction may be related to low resting sympathetic tone in patients with apparent unidirectional anterogradely conducting accessory pathways (UACAP).
Methods and Results: To test this hypothesis, we studied the effect of isoproterenol on accessory pathway function and tachycardia induction in 18 patients (12 men and 6 women, ages 34 ± 16 years [mean ± SD]) with UACAP. After baseline study in the drug‐free state, electrophysiologic testing was repeated during infusion of isoproterenol (0.5 to 1.5 μg/min, titrated to increase heart rate by 20%). Isoproterenol shortened the anterograde effective refractory period (398 ± 117 vs 305 ± 63 msec; P < 0.01; basic drive cycle length 600 msec) of the accessory pathway. However, retrograde accessory pathway conduction and atrioventricular reentrant tachycardia were exposed in only 3 (17%) patients by isoproterenol infusion. All 3 patients with retrograde accessory pathway revealed after isoproterenol had clinically documented tachycardia (supraventricular tachycardia in 2, atrial fibrillation in 1) during exercise, while none of the patients with persistent absence of retrograde accessory pathway conduction had this symptom.
Conclusions: We conclude that absence of overt retrograde conduction over accessory pathways may be related to low resting sympathetic tone in some individuals. Restoration of retrograde conduction with isoproterenol is unusual and most likely to be observed in patients with clinically documented paroxysmal supraventricular tachycardia related to exercise.</description><subject>Accessory Nerve - drug effects</subject><subject>Accessory Nerve - physiology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Atrioventricular Node - physiology</subject><subject>Bundle of His - physiology</subject><subject>Electrocardiography</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>isoproterenol</subject><subject>Isoproterenol - pharmacology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neural Conduction - drug effects</subject><subject>Neural Conduction - physiology</subject><subject>retrograde accessory pathway conduction</subject><subject>Retrograde Degeneration - physiology</subject><subject>Tachycardia - physiopathology</subject><subject>Tachycardia, Atrioventricular Nodal Reentry - physiopathology</subject><subject>Tachycardia, Ventricular - physiopathology</subject><issn>1045-3873</issn><issn>1540-8167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1PwyAUhonR-DH9CSbEC-9aoRRovTAxy_xcnBrNEm8IpaCdXVGguv1722zZvecGkvec58ADwAlGMe7qbBZjmqIow4zHOM9pHAqEOMvixRbY30Tb3R2lNCIZJ3vgwPsZQpgwRHfBLmcJYmmyD55GxmgVoDXw1tsvZ4N2urE1tA28VEp7b90SPsrw8SuXHk6r8GHbACc_2gX4rIOz706WGg5tU7YqVLY5BDtG1l4frc8BeL0avQxvovHk-nZ4OY5UygmKmDKUJVTlScILk2S8SE1JWaY4zVKKy65wyQuFS0VZLgkqk9yQQhYSkTwnlAzA6YrbPfq71T6IeeWVrmvZaNt6wXnafx93jeerRuWs904b8eWquXRLgZHofYqZ6KWJXprofYq1T7Hoho_XW9pirsvN6Fpgl1-s8t-q1st_kMXdcIQ56gDRClD5oBcbgHSfgnHCqZg-XIv79IlPp9mbGJM_uHqVbQ</recordid><startdate>199503</startdate><enddate>199503</enddate><creator>LI, HUAGUI G.</creator><creator>YEE, RAYMOND</creator><creator>KLEIN, GEORGE J.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199503</creationdate><title>Effect of Isoproterenol on Accessory Pathways Without Overt Retrograde Conduction</title><author>LI, HUAGUI G. ; YEE, RAYMOND ; KLEIN, GEORGE J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4730-6cf5625c9227bf287b4fd568c758451dddd1d7bc1dc569a30d29f3baba0399353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Accessory Nerve - drug effects</topic><topic>Accessory Nerve - physiology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Atrioventricular Node - physiology</topic><topic>Bundle of His - physiology</topic><topic>Electrocardiography</topic><topic>Exercise - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>isoproterenol</topic><topic>Isoproterenol - pharmacology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neural Conduction - drug effects</topic><topic>Neural Conduction - physiology</topic><topic>retrograde accessory pathway conduction</topic><topic>Retrograde Degeneration - physiology</topic><topic>Tachycardia - physiopathology</topic><topic>Tachycardia, Atrioventricular Nodal Reentry - physiopathology</topic><topic>Tachycardia, Ventricular - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LI, HUAGUI G.</creatorcontrib><creatorcontrib>YEE, RAYMOND</creatorcontrib><creatorcontrib>KLEIN, GEORGE J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular electrophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LI, HUAGUI G.</au><au>YEE, RAYMOND</au><au>KLEIN, GEORGE J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Isoproterenol on Accessory Pathways Without Overt Retrograde Conduction</atitle><jtitle>Journal of cardiovascular electrophysiology</jtitle><addtitle>J Cardiovasc Electrophysiol</addtitle><date>1995-03</date><risdate>1995</risdate><volume>6</volume><issue>3</issue><spage>170</spage><epage>173</epage><pages>170-173</pages><issn>1045-3873</issn><eissn>1540-8167</eissn><abstract>Effect of Isoproterenol on Accessory Pathways. Introduction: Absence of overt retrograde accessory pathway conduction may be related to low resting sympathetic tone in patients with apparent unidirectional anterogradely conducting accessory pathways (UACAP).
Methods and Results: To test this hypothesis, we studied the effect of isoproterenol on accessory pathway function and tachycardia induction in 18 patients (12 men and 6 women, ages 34 ± 16 years [mean ± SD]) with UACAP. After baseline study in the drug‐free state, electrophysiologic testing was repeated during infusion of isoproterenol (0.5 to 1.5 μg/min, titrated to increase heart rate by 20%). Isoproterenol shortened the anterograde effective refractory period (398 ± 117 vs 305 ± 63 msec; P < 0.01; basic drive cycle length 600 msec) of the accessory pathway. However, retrograde accessory pathway conduction and atrioventricular reentrant tachycardia were exposed in only 3 (17%) patients by isoproterenol infusion. All 3 patients with retrograde accessory pathway revealed after isoproterenol had clinically documented tachycardia (supraventricular tachycardia in 2, atrial fibrillation in 1) during exercise, while none of the patients with persistent absence of retrograde accessory pathway conduction had this symptom.
Conclusions: We conclude that absence of overt retrograde conduction over accessory pathways may be related to low resting sympathetic tone in some individuals. Restoration of retrograde conduction with isoproterenol is unusual and most likely to be observed in patients with clinically documented paroxysmal supraventricular tachycardia related to exercise.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7620642</pmid><doi>10.1111/j.1540-8167.1995.tb00768.x</doi><tpages>4</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1045-3873 |
ispartof | Journal of cardiovascular electrophysiology, 1995-03, Vol.6 (3), p.170-173 |
issn | 1045-3873 1540-8167 |
language | eng |
recordid | cdi_proquest_miscellaneous_77410451 |
source | MEDLINE; Access via Wiley Online Library |
subjects | Accessory Nerve - drug effects Accessory Nerve - physiology Adolescent Adult Aged Atrioventricular Node - physiology Bundle of His - physiology Electrocardiography Exercise - physiology Female Humans isoproterenol Isoproterenol - pharmacology Male Middle Aged Neural Conduction - drug effects Neural Conduction - physiology retrograde accessory pathway conduction Retrograde Degeneration - physiology Tachycardia - physiopathology Tachycardia, Atrioventricular Nodal Reentry - physiopathology Tachycardia, Ventricular - physiopathology |
title | Effect of Isoproterenol on Accessory Pathways Without Overt Retrograde Conduction |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T00%3A11%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Isoproterenol%20on%20Accessory%20Pathways%20Without%20Overt%20Retrograde%20Conduction&rft.jtitle=Journal%20of%20cardiovascular%20electrophysiology&rft.au=LI,%20HUAGUI%20G.&rft.date=1995-03&rft.volume=6&rft.issue=3&rft.spage=170&rft.epage=173&rft.pages=170-173&rft.issn=1045-3873&rft.eissn=1540-8167&rft_id=info:doi/10.1111/j.1540-8167.1995.tb00768.x&rft_dat=%3Cproquest_cross%3E77410451%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77410451&rft_id=info:pmid/7620642&rfr_iscdi=true |