Effect of Isoproterenol on Accessory Pathways Without Overt Retrograde Conduction

Effect of Isoproterenol on Accessory Pathways. Introduction: Absence of overt retrograde accessory pathway conduction may be related to low resting sympathetic tone in patients with apparent unidirectional anterogradely conducting accessory pathways (UACAP). Methods and Results: To test this hypothe...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of cardiovascular electrophysiology 1995-03, Vol.6 (3), p.170-173
Hauptverfasser: LI, HUAGUI G., YEE, RAYMOND, KLEIN, GEORGE J.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 173
container_issue 3
container_start_page 170
container_title Journal of cardiovascular electrophysiology
container_volume 6
creator LI, HUAGUI G.
YEE, RAYMOND
KLEIN, GEORGE J.
description Effect of Isoproterenol on Accessory Pathways. Introduction: Absence of overt retrograde accessory pathway conduction may be related to low resting sympathetic tone in patients with apparent unidirectional anterogradely conducting accessory pathways (UACAP). Methods and Results: To test this hypothesis, we studied the effect of isoproterenol on accessory pathway function and tachycardia induction in 18 patients (12 men and 6 women, ages 34 ± 16 years [mean ± SD]) with UACAP. After baseline study in the drug‐free state, electrophysiologic testing was repeated during infusion of isoproterenol (0.5 to 1.5 μg/min, titrated to increase heart rate by 20%). Isoproterenol shortened the anterograde effective refractory period (398 ± 117 vs 305 ± 63 msec; P < 0.01; basic drive cycle length 600 msec) of the accessory pathway. However, retrograde accessory pathway conduction and atrioventricular reentrant tachycardia were exposed in only 3 (17%) patients by isoproterenol infusion. All 3 patients with retrograde accessory pathway revealed after isoproterenol had clinically documented tachycardia (supraventricular tachycardia in 2, atrial fibrillation in 1) during exercise, while none of the patients with persistent absence of retrograde accessory pathway conduction had this symptom. Conclusions: We conclude that absence of overt retrograde conduction over accessory pathways may be related to low resting sympathetic tone in some individuals. Restoration of retrograde conduction with isoproterenol is unusual and most likely to be observed in patients with clinically documented paroxysmal supraventricular tachycardia related to exercise.
doi_str_mv 10.1111/j.1540-8167.1995.tb00768.x
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77410451</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77410451</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4730-6cf5625c9227bf287b4fd568c758451dddd1d7bc1dc569a30d29f3baba0399353</originalsourceid><addsrcrecordid>eNqVkF1PwyAUhonR-DH9CSbEC-9aoRRovTAxy_xcnBrNEm8IpaCdXVGguv1722zZvecGkvec58ADwAlGMe7qbBZjmqIow4zHOM9pHAqEOMvixRbY30Tb3R2lNCIZJ3vgwPsZQpgwRHfBLmcJYmmyD55GxmgVoDXw1tsvZ4N2urE1tA28VEp7b90SPsrw8SuXHk6r8GHbACc_2gX4rIOz706WGg5tU7YqVLY5BDtG1l4frc8BeL0avQxvovHk-nZ4OY5UygmKmDKUJVTlScILk2S8SE1JWaY4zVKKy65wyQuFS0VZLgkqk9yQQhYSkTwnlAzA6YrbPfq71T6IeeWVrmvZaNt6wXnafx93jeerRuWs904b8eWquXRLgZHofYqZ6KWJXprofYq1T7Hoho_XW9pirsvN6Fpgl1-s8t-q1st_kMXdcIQ56gDRClD5oBcbgHSfgnHCqZg-XIv79IlPp9mbGJM_uHqVbQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77410451</pqid></control><display><type>article</type><title>Effect of Isoproterenol on Accessory Pathways Without Overt Retrograde Conduction</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>LI, HUAGUI G. ; YEE, RAYMOND ; KLEIN, GEORGE J.</creator><creatorcontrib>LI, HUAGUI G. ; YEE, RAYMOND ; KLEIN, GEORGE J.</creatorcontrib><description>Effect of Isoproterenol on Accessory Pathways. Introduction: Absence of overt retrograde accessory pathway conduction may be related to low resting sympathetic tone in patients with apparent unidirectional anterogradely conducting accessory pathways (UACAP). Methods and Results: To test this hypothesis, we studied the effect of isoproterenol on accessory pathway function and tachycardia induction in 18 patients (12 men and 6 women, ages 34 ± 16 years [mean ± SD]) with UACAP. After baseline study in the drug‐free state, electrophysiologic testing was repeated during infusion of isoproterenol (0.5 to 1.5 μg/min, titrated to increase heart rate by 20%). Isoproterenol shortened the anterograde effective refractory period (398 ± 117 vs 305 ± 63 msec; P &lt; 0.01; basic drive cycle length 600 msec) of the accessory pathway. However, retrograde accessory pathway conduction and atrioventricular reentrant tachycardia were exposed in only 3 (17%) patients by isoproterenol infusion. All 3 patients with retrograde accessory pathway revealed after isoproterenol had clinically documented tachycardia (supraventricular tachycardia in 2, atrial fibrillation in 1) during exercise, while none of the patients with persistent absence of retrograde accessory pathway conduction had this symptom. Conclusions: We conclude that absence of overt retrograde conduction over accessory pathways may be related to low resting sympathetic tone in some individuals. Restoration of retrograde conduction with isoproterenol is unusual and most likely to be observed in patients with clinically documented paroxysmal supraventricular tachycardia related to exercise.</description><identifier>ISSN: 1045-3873</identifier><identifier>EISSN: 1540-8167</identifier><identifier>DOI: 10.1111/j.1540-8167.1995.tb00768.x</identifier><identifier>PMID: 7620642</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Accessory Nerve - drug effects ; Accessory Nerve - physiology ; Adolescent ; Adult ; Aged ; Atrioventricular Node - physiology ; Bundle of His - physiology ; Electrocardiography ; Exercise - physiology ; Female ; Humans ; isoproterenol ; Isoproterenol - pharmacology ; Male ; Middle Aged ; Neural Conduction - drug effects ; Neural Conduction - physiology ; retrograde accessory pathway conduction ; Retrograde Degeneration - physiology ; Tachycardia - physiopathology ; Tachycardia, Atrioventricular Nodal Reentry - physiopathology ; Tachycardia, Ventricular - physiopathology</subject><ispartof>Journal of cardiovascular electrophysiology, 1995-03, Vol.6 (3), p.170-173</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4730-6cf5625c9227bf287b4fd568c758451dddd1d7bc1dc569a30d29f3baba0399353</citedby><cites>FETCH-LOGICAL-c4730-6cf5625c9227bf287b4fd568c758451dddd1d7bc1dc569a30d29f3baba0399353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1540-8167.1995.tb00768.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1540-8167.1995.tb00768.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27926,27927,45576,45577</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7620642$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LI, HUAGUI G.</creatorcontrib><creatorcontrib>YEE, RAYMOND</creatorcontrib><creatorcontrib>KLEIN, GEORGE J.</creatorcontrib><title>Effect of Isoproterenol on Accessory Pathways Without Overt Retrograde Conduction</title><title>Journal of cardiovascular electrophysiology</title><addtitle>J Cardiovasc Electrophysiol</addtitle><description>Effect of Isoproterenol on Accessory Pathways. Introduction: Absence of overt retrograde accessory pathway conduction may be related to low resting sympathetic tone in patients with apparent unidirectional anterogradely conducting accessory pathways (UACAP). Methods and Results: To test this hypothesis, we studied the effect of isoproterenol on accessory pathway function and tachycardia induction in 18 patients (12 men and 6 women, ages 34 ± 16 years [mean ± SD]) with UACAP. After baseline study in the drug‐free state, electrophysiologic testing was repeated during infusion of isoproterenol (0.5 to 1.5 μg/min, titrated to increase heart rate by 20%). Isoproterenol shortened the anterograde effective refractory period (398 ± 117 vs 305 ± 63 msec; P &lt; 0.01; basic drive cycle length 600 msec) of the accessory pathway. However, retrograde accessory pathway conduction and atrioventricular reentrant tachycardia were exposed in only 3 (17%) patients by isoproterenol infusion. All 3 patients with retrograde accessory pathway revealed after isoproterenol had clinically documented tachycardia (supraventricular tachycardia in 2, atrial fibrillation in 1) during exercise, while none of the patients with persistent absence of retrograde accessory pathway conduction had this symptom. Conclusions: We conclude that absence of overt retrograde conduction over accessory pathways may be related to low resting sympathetic tone in some individuals. Restoration of retrograde conduction with isoproterenol is unusual and most likely to be observed in patients with clinically documented paroxysmal supraventricular tachycardia related to exercise.</description><subject>Accessory Nerve - drug effects</subject><subject>Accessory Nerve - physiology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Atrioventricular Node - physiology</subject><subject>Bundle of His - physiology</subject><subject>Electrocardiography</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>isoproterenol</subject><subject>Isoproterenol - pharmacology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neural Conduction - drug effects</subject><subject>Neural Conduction - physiology</subject><subject>retrograde accessory pathway conduction</subject><subject>Retrograde Degeneration - physiology</subject><subject>Tachycardia - physiopathology</subject><subject>Tachycardia, Atrioventricular Nodal Reentry - physiopathology</subject><subject>Tachycardia, Ventricular - physiopathology</subject><issn>1045-3873</issn><issn>1540-8167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1PwyAUhonR-DH9CSbEC-9aoRRovTAxy_xcnBrNEm8IpaCdXVGguv1722zZvecGkvec58ADwAlGMe7qbBZjmqIow4zHOM9pHAqEOMvixRbY30Tb3R2lNCIZJ3vgwPsZQpgwRHfBLmcJYmmyD55GxmgVoDXw1tsvZ4N2urE1tA28VEp7b90SPsrw8SuXHk6r8GHbACc_2gX4rIOz706WGg5tU7YqVLY5BDtG1l4frc8BeL0avQxvovHk-nZ4OY5UygmKmDKUJVTlScILk2S8SE1JWaY4zVKKy65wyQuFS0VZLgkqk9yQQhYSkTwnlAzA6YrbPfq71T6IeeWVrmvZaNt6wXnafx93jeerRuWs904b8eWquXRLgZHofYqZ6KWJXprofYq1T7Hoho_XW9pirsvN6Fpgl1-s8t-q1st_kMXdcIQ56gDRClD5oBcbgHSfgnHCqZg-XIv79IlPp9mbGJM_uHqVbQ</recordid><startdate>199503</startdate><enddate>199503</enddate><creator>LI, HUAGUI G.</creator><creator>YEE, RAYMOND</creator><creator>KLEIN, GEORGE J.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199503</creationdate><title>Effect of Isoproterenol on Accessory Pathways Without Overt Retrograde Conduction</title><author>LI, HUAGUI G. ; YEE, RAYMOND ; KLEIN, GEORGE J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4730-6cf5625c9227bf287b4fd568c758451dddd1d7bc1dc569a30d29f3baba0399353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Accessory Nerve - drug effects</topic><topic>Accessory Nerve - physiology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Atrioventricular Node - physiology</topic><topic>Bundle of His - physiology</topic><topic>Electrocardiography</topic><topic>Exercise - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>isoproterenol</topic><topic>Isoproterenol - pharmacology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neural Conduction - drug effects</topic><topic>Neural Conduction - physiology</topic><topic>retrograde accessory pathway conduction</topic><topic>Retrograde Degeneration - physiology</topic><topic>Tachycardia - physiopathology</topic><topic>Tachycardia, Atrioventricular Nodal Reentry - physiopathology</topic><topic>Tachycardia, Ventricular - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LI, HUAGUI G.</creatorcontrib><creatorcontrib>YEE, RAYMOND</creatorcontrib><creatorcontrib>KLEIN, GEORGE J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular electrophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LI, HUAGUI G.</au><au>YEE, RAYMOND</au><au>KLEIN, GEORGE J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Isoproterenol on Accessory Pathways Without Overt Retrograde Conduction</atitle><jtitle>Journal of cardiovascular electrophysiology</jtitle><addtitle>J Cardiovasc Electrophysiol</addtitle><date>1995-03</date><risdate>1995</risdate><volume>6</volume><issue>3</issue><spage>170</spage><epage>173</epage><pages>170-173</pages><issn>1045-3873</issn><eissn>1540-8167</eissn><abstract>Effect of Isoproterenol on Accessory Pathways. Introduction: Absence of overt retrograde accessory pathway conduction may be related to low resting sympathetic tone in patients with apparent unidirectional anterogradely conducting accessory pathways (UACAP). Methods and Results: To test this hypothesis, we studied the effect of isoproterenol on accessory pathway function and tachycardia induction in 18 patients (12 men and 6 women, ages 34 ± 16 years [mean ± SD]) with UACAP. After baseline study in the drug‐free state, electrophysiologic testing was repeated during infusion of isoproterenol (0.5 to 1.5 μg/min, titrated to increase heart rate by 20%). Isoproterenol shortened the anterograde effective refractory period (398 ± 117 vs 305 ± 63 msec; P &lt; 0.01; basic drive cycle length 600 msec) of the accessory pathway. However, retrograde accessory pathway conduction and atrioventricular reentrant tachycardia were exposed in only 3 (17%) patients by isoproterenol infusion. All 3 patients with retrograde accessory pathway revealed after isoproterenol had clinically documented tachycardia (supraventricular tachycardia in 2, atrial fibrillation in 1) during exercise, while none of the patients with persistent absence of retrograde accessory pathway conduction had this symptom. Conclusions: We conclude that absence of overt retrograde conduction over accessory pathways may be related to low resting sympathetic tone in some individuals. Restoration of retrograde conduction with isoproterenol is unusual and most likely to be observed in patients with clinically documented paroxysmal supraventricular tachycardia related to exercise.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7620642</pmid><doi>10.1111/j.1540-8167.1995.tb00768.x</doi><tpages>4</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1045-3873
ispartof Journal of cardiovascular electrophysiology, 1995-03, Vol.6 (3), p.170-173
issn 1045-3873
1540-8167
language eng
recordid cdi_proquest_miscellaneous_77410451
source MEDLINE; Access via Wiley Online Library
subjects Accessory Nerve - drug effects
Accessory Nerve - physiology
Adolescent
Adult
Aged
Atrioventricular Node - physiology
Bundle of His - physiology
Electrocardiography
Exercise - physiology
Female
Humans
isoproterenol
Isoproterenol - pharmacology
Male
Middle Aged
Neural Conduction - drug effects
Neural Conduction - physiology
retrograde accessory pathway conduction
Retrograde Degeneration - physiology
Tachycardia - physiopathology
Tachycardia, Atrioventricular Nodal Reentry - physiopathology
Tachycardia, Ventricular - physiopathology
title Effect of Isoproterenol on Accessory Pathways Without Overt Retrograde Conduction
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T00%3A11%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Isoproterenol%20on%20Accessory%20Pathways%20Without%20Overt%20Retrograde%20Conduction&rft.jtitle=Journal%20of%20cardiovascular%20electrophysiology&rft.au=LI,%20HUAGUI%20G.&rft.date=1995-03&rft.volume=6&rft.issue=3&rft.spage=170&rft.epage=173&rft.pages=170-173&rft.issn=1045-3873&rft.eissn=1540-8167&rft_id=info:doi/10.1111/j.1540-8167.1995.tb00768.x&rft_dat=%3Cproquest_cross%3E77410451%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77410451&rft_id=info:pmid/7620642&rfr_iscdi=true