Molecular characterization of a (1;10)(p22;q21) constitutional translocation from a patient with neuroblastoma

A constitutional t(1;10)(p22;q21) from a patient with stage IVS neuroblastoma has been isolated in somatic cell hybrids and the position of the breakpoints analyzed. On chromosome 1 the breakpoint lies in a 4-Mbp region flanked by minisatellite marker D1S234 and by D1S188, which lies in the region o...

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Veröffentlicht in:	Cancer genetics and cytogenetics 1995-06, Vol.81 (2), p.151-157
Hauptverfasser:	Scott Mead, R., Cowell, John K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences breakpoints Chromosome 1 Chromosome 10 Chromosome Mapping Chromosomes, Human, Pair 1 - genetics Chromosomes, Human, Pair 10 - genetics DNA Probes DNA, Neoplasm - analysis Female Humans Infant man Medical sciences Molecular Sequence Data neuroblastoma Neuroblastoma - genetics Neurology Retroperitoneal Neoplasms - genetics translocation Translocation, Genetic - genetics Tumors of the nervous system. Phacomatoses
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Zusammenfassung:	A constitutional t(1;10)(p22;q21) from a patient with stage IVS neuroblastoma has been isolated in somatic cell hybrids and the position of the breakpoints analyzed. On chromosome 1 the breakpoint lies in a 4-Mbp region flanked by minisatellite marker D1S234 and by D1S188, which lies in the region of F3. The chromosome 10 breakpoint lies between RBP3 and NAKNR below the MEN2 locus. Because, in patients with genetic disease, constitutional translocations frequently interrupt genes which are related to the clinical phenotype this rearrangement has identified two regions which potentially contain genes related to the development of neuroblastoma.
ISSN:	0165-4608 1873-4456
DOI:	10.1016/0165-4608(94)00216-X