Residence times of the buried water molecules in bovine pancreatic trypsin inhibitor and its G36S mutant

The three-dimensional structure of the bovine pancreatic trypsin inhibitor (BPTI) contains 4 internal water molecules, denoted W111, W112, W113, and W122, the latter being replaced by a seryl side chain in the BPTI(G36S) analogue. To investigate the effect of the exchange between these explicit wate...

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Veröffentlicht in:	Biochemistry (Easton) 1995-07, Vol.34 (28), p.9046-9051
Hauptverfasser:	Denisov, Vladimir P, Halle, Bertil, Peters, Joerg, Hoerlein, Hans Dietrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Aprotinin - chemistry Aprotinin - genetics Cattle Hydrogen Bonding Magnetic Resonance Spectroscopy Models, Molecular Molecular Sequence Data Molecular Structure Point Mutation Protein Conformation Water - chemistry
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