alpha.-Methylproline-containing renin inhibitory peptides: in vivo evaluation in an anesthetized, ganglion-blocked, hog renin infused rat model

A structure-activity analysis of peptides containing backbone C alpha-methyl modification at the P4 site of the angiotensinogen sequence led to the discovery of potent renin inhibitors with apparent in vitro metabolic stability. Boc-alpha-MePro-Phe-His-Leu psi[CHOHCH2]Val-Ile-Amp dicitrate (Va) is a...

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Veröffentlicht in:	Journal of medicinal chemistry 1987-03, Vol.30 (3), p.536-541
Hauptverfasser:	Thaisrivongs, Suvit, Pals, Donald T, Lawson, Judy A, Turner, Steve R, Harris, Douglas W
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological and medical sciences Chemical Phenomena Chemistry General pharmacology Humans Indicators and Reagents Kinetics Male Medical sciences Oligopeptides - chemical synthesis Oligopeptides - pharmacology Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Proline - analogs & derivatives Rats Rats, Inbred Strains Renin - antagonists & inhibitors Renin - blood Swine
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