Enhancement of Neurite Outgrowth Following Calpain Inhibition Is Mediated by Protein Kinase C

: We examined the interdependence of calpain and protein kinase C (PKC) activities on neurite outgrowth in SH‐SY‐5Y human neuroblastoma cells. SH‐SY‐5Y cells elaborated neurites when deprived of serum or after a specific thrombin inhibitor, hirudin, was added to serum‐containing medium. The extent o...

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Veröffentlicht in:	Journal of neurochemistry 1995-08, Vol.65 (2), p.517-527
Hauptverfasser:	Shea, Thomas B., Cressman, Corinne M., Spencer, Melissa J., Beermann, Mary Lou, Nixon, Ralph A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood Physiological Phenomena Calpain Calpain - antagonists & inhibitors Calpain - metabolism Calpastatin Calpeptin Fundamental and applied biological sciences. Psychology Hirudin Hirudins - pharmacology Humans Isolated neuron and nerve. Neuroglia Neurites - physiology Neuritogenesis Neuronal differentiation Phosphotransferases - antagonists & inhibitors Protease Inhibitors - pharmacology Protein kinase C Protein Kinase C - physiology Thrombin Tumor Cells, Cultured Vertebrates: nervous system and sense organs
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