Transepithelial transport properties of peptidomimetic thrombin inhibitors in monolayers of a human intestinal cell line (Caco-2) and their correlation to in vivo data

Peptidomimetic thrombin inhibitors (TI), derived from L-Asp-D-Phe were examined in confluent monolayers of a human colon carcinoma cell line (Caco-2) to elucidate their transepithelial transport properties. Effect availabilities, based on activated partial thromboplastin time (aPTT) measurements in...

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Veröffentlicht in:	Pharmaceutical research 1995-03, Vol.12 (3), p.360-365
Hauptverfasser:	WALTER, E, KISSEL, T, REERS, M, DICKNEITE, G, HOFFMANN, D, STÜBER, W
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biological Availability Blood. Blood coagulation. Reticuloendothelial system Cells, Cultured Dose-Response Relationship, Drug Humans Intestines - drug effects Medical sciences Permeability Pharmacology. Drug treatments Thrombin - antagonists & inhibitors Thrombin - chemistry Thrombin - metabolism
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