DALDA (H-Tyr-D-Arg-Phe-Lys-NH 2), a potent μ-opioid peptide agonist, affects various patterns of locomotor activities

The central effects of μ-opioid receptor agonist DALDA (ICV 0.00, 0.1, or 1.0 μg) were investigated in rats for 120 min on activity monitors. The durations in seconds of horizontal movement time, rearing time, and stereotypy time were measured during 12 consecutive 10-min time blocks. DALDA (ICV, 0....

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1995-05, Vol.51 (1), p.149-151
Hauptverfasser:	Meyer, Merle E., McLaurin, Bonnie I., Meyer, Melissa E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analgesics - administration & dosage Analgesics - pharmacology Animals Biological and medical sciences DALDA Injections, Intraventricular Locomotion - drug effects Locomotor activity Male Medical sciences Molecular Sequence Data Motor Activity - drug effects Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Oligopeptides - administration & dosage Oligopeptides - pharmacology Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Rats Rearing Linear locomotion Receptors, Opioid, mu - agonists Stereotyped Behavior - drug effects Stereotypy μ-Opioid peptide agonists
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Zusammenfassung:	The central effects of μ-opioid receptor agonist DALDA (ICV 0.00, 0.1, or 1.0 μg) were investigated in rats for 120 min on activity monitors. The durations in seconds of horizontal movement time, rearing time, and stereotypy time were measured during 12 consecutive 10-min time blocks. DALDA (ICV, 0.1 and 1.0 μg) resulted in biphasic effects, inhibition followed by activation for horizontal movement, rearing, and stereotypy times.
ISSN:	0091-3057 1873-5177
DOI:	10.1016/0091-3057(94)00308-6