Targeted Disruption of Mouse EGF Receptor: Effect of Genetic Background on Mutant Phenotype

Gene targeting was used to create a null allele at the epidermal growth factor receptor locus (Egfr). The phenotype was dependent on genetic background. EGFR deficiency on a CF-1 background resulted in peri-implantation death due to degeneration of the inner cell mass. On a 129/Sv background, homozy...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1995-07, Vol.269 (5221), p.230-234
Hauptverfasser:	Threadgill, David W., Dlugosz, Andrzej A., Hansen, Laura A., Tennenbaum, Tamar, Lichti, Ulrike, Yee, Della, LaMantia, Christian, Mourton, Tracy, Herrup, Karl, Harris, Raymond C., Barnard, John A., Yuspa, Stuart H., Coffey, Robert J., Magnuson, Terry
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Multiple - genetics Alleles Animals Base Sequence Biological and medical sciences Brain - abnormalities Brain - cytology Cell Division Cellular biology Classical genetics, quantitative genetics, hybrids Digestive System - cytology Digestive System Abnormalities Embryo implantation Embryonic and Fetal Development Embryos ErbB Receptors - deficiency ErbB Receptors - genetics ErbB Receptors - physiology Exons Female Fundamental and applied biological sciences. Psychology Gene Targeting Genetics Genetics of eukaryotes. Biological and molecular evolution Giant cells Hair - abnormalities Hepatocytes Histology Homozygote Individualized Instruction Kidney - cytology Kidney cells Lung - cytology Male Mice Molecular Sequence Data Mutation Phenotype Phenotypes Pregnancy Rodents Scientific Concepts Skin - cytology Skin Abnormalities Vertebrata
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