Coxsackie B virus infection and onset of childhood diabetes
Infection with Coxsackie B viruses has been linked to insulin-dependent diabetes mellitus. Nine of 14 serum samples (64%) taken from children at the onset of diabetes were positive for enterovirus RNA by PCR. All of the children were under age six, and five were under age three. By contrast, enterov...
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| Veröffentlicht in: | The Lancet (British edition) 1995-07, Vol.346 (8969), p.221-223 |
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| creator | Clements, G.B Galbraith, D.N Taylor, K.W |
| description | Infection with Coxsackie B viruses has been linked to insulin-dependent diabetes mellitus. Nine of 14 serum samples (64%) taken from children at the onset of diabetes were positive for enterovirus RNA by PCR. All of the children were under age six, and five were under age three. By contrast, enterovirus sequences were detected in only two of 45 serum samples from appropriate comparison children (4%). Sequences from six of the positive patients showed strong homology with Coxsackie B3 and B4 viruses, and there were some common patterns among the sequences from infected diabetic children. This is evidence for a role for enteroviruses in childhood diabetes. |
| doi_str_mv | 10.1016/S0140-6736(95)91270-3 |
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Nine of 14 serum samples (64%) taken from children at the onset of diabetes were positive for enterovirus RNA by PCR. All of the children were under age six, and five were under age three. By contrast, enterovirus sequences were detected in only two of 45 serum samples from appropriate comparison children (4%). Sequences from six of the positive patients showed strong homology with Coxsackie B3 and B4 viruses, and there were some common patterns among the sequences from infected diabetic children. This is evidence for a role for enteroviruses in childhood diabetes.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(95)91270-3</identifier><identifier>PMID: 7616803</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Base Sequence ; Biological and medical sciences ; Child ; Child, Preschool ; Children & youth ; Coxsackievirus Infections - complications ; Coxsackievirus Infections - genetics ; Diabetes ; Diabetes Mellitus, Type 1 - virology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Enterovirus B, Human - genetics ; Enterovirus B, Human - isolation & purification ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Humans ; Infant ; Infections ; Insulin ; Male ; Medical research ; Medical sciences ; Molecular Sequence Data ; Polymerase Chain Reaction ; RNA, Viral - blood ; RNA, Viral - chemistry ; Sequence Homology, Nucleic Acid ; Viruses</subject><ispartof>The Lancet (British edition), 1995-07, Vol.346 (8969), p.221-223</ispartof><rights>1995</rights><rights>1995 INIST-CNRS</rights><rights>Copyright Lancet Ltd. 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Nine of 14 serum samples (64%) taken from children at the onset of diabetes were positive for enterovirus RNA by PCR. All of the children were under age six, and five were under age three. By contrast, enterovirus sequences were detected in only two of 45 serum samples from appropriate comparison children (4%). Sequences from six of the positive patients showed strong homology with Coxsackie B3 and B4 viruses, and there were some common patterns among the sequences from infected diabetic children. This is evidence for a role for enteroviruses in childhood diabetes.</description><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>Coxsackievirus Infections - complications</subject><subject>Coxsackievirus Infections - genetics</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 1 - virology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Enterovirus B, Human - genetics</subject><subject>Enterovirus B, Human - isolation & purification</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infections</subject><subject>Insulin</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Polymerase Chain Reaction</subject><subject>RNA, Viral - blood</subject><subject>RNA, Viral - chemistry</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Viruses</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkMtqHDEQRYVJsCeOP8HQhBCcRTul1quFFyYe8gKDF0kgO6GRSlh2T8uWuk3y99F4hllkk1Ut6tzi1iHklMI5BSo_fAfKoZWKyTMt3mvaKWjZAVlQrngruPr1giz2yBF5VcodAHAJ4pAcKkllD2xBLpbpd7HuPmJz1TzFPJcmjgHdFNPY2NE3aSw4NSk07jYO_jYl3_hoVzhheU1eBjsUPNnNY_Lz86cfy6_t9c2Xb8uP160TjE8tg66XdhVsry2VWmFPEbmyTtQ_RIDe9150EhhXSigUECz10gXHNZWyD-yYvNvefcjpccYymXUsDofBjpjmYpTiUFlewTf_gHdpzmPtZqjW0HXAuwqJLeRyKiVjMA85rm3-YyiYjVnzbNZstBktzLNZw2rudHd8Xq3R71M7lXX_dre3xdkhZDu6WPYYE1oKtel4ucWwGnuKmE1xEUeHPuaq3fgU_1PkLw6Xko0</recordid><startdate>19950722</startdate><enddate>19950722</enddate><creator>Clements, G.B</creator><creator>Galbraith, D.N</creator><creator>Taylor, K.W</creator><general>Elsevier Ltd</general><general>Lancet</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TT</scope><scope>0TZ</scope><scope>0U~</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>KB~</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>19950722</creationdate><title>Coxsackie B virus infection and onset of childhood diabetes</title><author>Clements, G.B ; Galbraith, D.N ; Taylor, K.W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-30286abfa89a1697e81ee47ac51015f08d8d5260347757e50fa1d6cfc491668f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>Coxsackievirus Infections - complications</topic><topic>Coxsackievirus Infections - genetics</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 1 - virology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Enterovirus B, Human - genetics</topic><topic>Enterovirus B, Human - isolation & purification</topic><topic>Etiopathogenesis. Screening. Investigations. 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Nine of 14 serum samples (64%) taken from children at the onset of diabetes were positive for enterovirus RNA by PCR. All of the children were under age six, and five were under age three. By contrast, enterovirus sequences were detected in only two of 45 serum samples from appropriate comparison children (4%). Sequences from six of the positive patients showed strong homology with Coxsackie B3 and B4 viruses, and there were some common patterns among the sequences from infected diabetic children. This is evidence for a role for enteroviruses in childhood diabetes.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>7616803</pmid><doi>10.1016/S0140-6736(95)91270-3</doi><tpages>3</tpages></addata></record> |
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| ispartof | The Lancet (British edition), 1995-07, Vol.346 (8969), p.221-223 |
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| subjects | Base Sequence Biological and medical sciences Child Child, Preschool Children & youth Coxsackievirus Infections - complications Coxsackievirus Infections - genetics Diabetes Diabetes Mellitus, Type 1 - virology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enterovirus B, Human - genetics Enterovirus B, Human - isolation & purification Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Humans Infant Infections Insulin Male Medical research Medical sciences Molecular Sequence Data Polymerase Chain Reaction RNA, Viral - blood RNA, Viral - chemistry Sequence Homology, Nucleic Acid Viruses |
| title | Coxsackie B virus infection and onset of childhood diabetes |
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