Modulation of morphine antinociception by the brain-penetrating H2 antagonist zolantidine : detailed characterization in five nociceptive test systems

Because histamine (HA) in the CNS may be a mediator of antinociception, a detailed investigation of the effects of the brain-penetrating H2 antagonist zolantidine (ZOL) was performed on five nociceptive tests in the presence and absence of morphine (MOR) in rats. ZOL inhibited MOR antinociception on...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1995-03, Vol.50 (3), p.421-429
Hauptverfasser:	NALWALK, J. W, KOCH, J. E, BARKE, K. E, BODNAR, R. J, HOUGH, L. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animals Benzothiazoles Biological and medical sciences Blood-Brain Barrier Histamine H2 Antagonists - pharmacology Hot Temperature Male Medical sciences Morphine - antagonists & inhibitors Morphine - pharmacology Neuropharmacology Pain - physiopathology Pain Measurement Pharmacology. Drug treatments Phenoxypropanolamines Piperidines - pharmacokinetics Rats Rats, Sprague-Dawley Reproducibility of Results Thiazoles - pharmacokinetics
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