Modulation of morphine antinociception by the brain-penetrating H2 antagonist zolantidine : detailed characterization in five nociceptive test systems

Because histamine (HA) in the CNS may be a mediator of antinociception, a detailed investigation of the effects of the brain-penetrating H2 antagonist zolantidine (ZOL) was performed on five nociceptive tests in the presence and absence of morphine (MOR) in rats. ZOL inhibited MOR antinociception on...

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Veröffentlicht in:Pharmacology, biochemistry and behavior biochemistry and behavior, 1995-03, Vol.50 (3), p.421-429
Hauptverfasser: NALWALK, J. W, KOCH, J. E, BARKE, K. E, BODNAR, R. J, HOUGH, L. B
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container_issue 3
container_start_page 421
container_title Pharmacology, biochemistry and behavior
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creator NALWALK, J. W
KOCH, J. E
BARKE, K. E
BODNAR, R. J
HOUGH, L. B
description Because histamine (HA) in the CNS may be a mediator of antinociception, a detailed investigation of the effects of the brain-penetrating H2 antagonist zolantidine (ZOL) was performed on five nociceptive tests in the presence and absence of morphine (MOR) in rats. ZOL inhibited MOR antinociception on the tail flick test, although a diurnal difference (inhibition in the dark cycle >> light cycle) was found. Similar results were found with the hot plate test, although details of the test procedure were significant. In contrast, ZOL induced opposing effects on MOR antinociception on two nonthermal tests (jump test and tail pinch test); ZOL alone induced moderate antinociception on the former test and mild antinociception on the latter test. Thus, ZOL exerts differential effects on baseline nociception and on MOR antinociception that vary depending on the nociceptive test employed, the light-dark cycle of the subjects, and the degree of stress associated with the nociceptive testing. These complex effects reveal the heterogeneous nature of opiate-induced modulation of nociception, and show that ZOL is a powerful tool for studying the relationships between opiates, HA, and nociceptive mechanisms.
doi_str_mv 10.1016/0091-3057(94)00291-P
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B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of morphine antinociception by the brain-penetrating H2 antagonist zolantidine : detailed characterization in five nociceptive test systems</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1995-03</date><risdate>1995</risdate><volume>50</volume><issue>3</issue><spage>421</spage><epage>429</epage><pages>421-429</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>Because histamine (HA) in the CNS may be a mediator of antinociception, a detailed investigation of the effects of the brain-penetrating H2 antagonist zolantidine (ZOL) was performed on five nociceptive tests in the presence and absence of morphine (MOR) in rats. ZOL inhibited MOR antinociception on the tail flick test, although a diurnal difference (inhibition in the dark cycle &gt;&gt; light cycle) was found. 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subjects Analgesics
Animals
Benzothiazoles
Biological and medical sciences
Blood-Brain Barrier
Histamine H2 Antagonists - pharmacology
Hot Temperature
Male
Medical sciences
Morphine - antagonists & inhibitors
Morphine - pharmacology
Neuropharmacology
Pain - physiopathology
Pain Measurement
Pharmacology. Drug treatments
Phenoxypropanolamines
Piperidines - pharmacokinetics
Rats
Rats, Sprague-Dawley
Reproducibility of Results
Thiazoles - pharmacokinetics
title Modulation of morphine antinociception by the brain-penetrating H2 antagonist zolantidine : detailed characterization in five nociceptive test systems
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