Increased frequency of the uncommon allele of a tumour necrosis factor alpha gene polymorphism in rheumatoid arthritis and systemic lupus erythematosus
The frequency of the uncommon allele (TNF2) of a polymorphism in the promoter region of the tumour necrosis factor alpha (TNF alpha) gene in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) was found to be 3 times that of the normal anglo-saxon population. In SLE patien...
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| Veröffentlicht in: | Disease markers 1995-03, Vol.12 (2), p.127-133 |
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| container_issue | 2 |
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| container_title | Disease markers |
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| creator | DANIS, V. A MILLINGTON, M HYLAND, V LAWFORD, R QIRONG HUANG GRENNAN, D |
| description | The frequency of the uncommon allele (TNF2) of a polymorphism in the promoter region of the tumour necrosis factor alpha (TNF alpha) gene in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) was found to be 3 times that of the normal anglo-saxon population. In SLE patients, this allele was strongly associated with HLA-DR3 expression and was also more frequent in patients who did not have malar rash. Functional studies of normal monocyte cytokine production in vitro showed that this genotype was associated with increased IL-1 alpha protein production but there were no differences in the production of TNF alpha protein. |
| doi_str_mv | 10.1155/1994/756247 |
| format | Article |
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Functional studies of normal monocyte cytokine production in vitro showed that this genotype was associated with increased IL-1 alpha protein production but there were no differences in the production of TNF alpha protein.</description><subject>Alleles</subject><subject>Arthritis, Rheumatoid - genetics</subject><subject>Biological and medical sciences</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>HLA-DR Antigens - genetics</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Lupus Erythematosus, Systemic - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Polymorphism, Genetic</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><issn>0278-0240</issn><issn>1875-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1TAQhS0EKreFFWskLxCbKtSPOLaXqOJRqRIbWEeOMyFBfgQ_Fvkl_N0mulfdshpp5pszmnMQekfJJ0qFuKNat3dSdKyVL9CJKika1XHyEp0Ik6ohrCWv0XXOfwihTLf6Cl3JjrZSsRP69xBsApNhxFOCvxWC3XCccJkB12Cj9zFg4xw4ONoGl-pjTTiATTEvGU_Glph2ZJ0N_g0B8Brd5mNa5yV7vAScZqjelLiM2KQyp6XsayaMOG-5gF8sdnWtGUPa9qsHmWt-g15NxmV4e6k36NfXLz_vvzePP7493H9-bCxXtDTKcDoRbpjgxLKRD7STbDIwGC6lJUy1io_DSAUIOXCutBSihYHw3YeWgeY36ONZd01x_z6X3i_ZgnMmQKy5l5LrfYn-F6Sd1oqIQ_H2DB4G5QRTv6bFm7T1lPRHXv2RV3_Oa6ffX2Tr4GF8Zi8B7fMPl7nJ1rgpmWCX_IzxVgvVKf4EOtSfqQ</recordid><startdate>19950301</startdate><enddate>19950301</enddate><creator>DANIS, V. 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A</creatorcontrib><creatorcontrib>MILLINGTON, M</creatorcontrib><creatorcontrib>HYLAND, V</creatorcontrib><creatorcontrib>LAWFORD, R</creatorcontrib><creatorcontrib>QIRONG HUANG</creatorcontrib><creatorcontrib>GRENNAN, D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DANIS, V. A</au><au>MILLINGTON, M</au><au>HYLAND, V</au><au>LAWFORD, R</au><au>QIRONG HUANG</au><au>GRENNAN, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased frequency of the uncommon allele of a tumour necrosis factor alpha gene polymorphism in rheumatoid arthritis and systemic lupus erythematosus</atitle><jtitle>Disease markers</jtitle><addtitle>Dis Markers</addtitle><date>1995-03-01</date><risdate>1995</risdate><volume>12</volume><issue>2</issue><spage>127</spage><epage>133</epage><pages>127-133</pages><issn>0278-0240</issn><eissn>1875-8630</eissn><coden>DMARD3</coden><abstract>The frequency of the uncommon allele (TNF2) of a polymorphism in the promoter region of the tumour necrosis factor alpha (TNF alpha) gene in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) was found to be 3 times that of the normal anglo-saxon population. 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| fulltext | fulltext |
| identifier | ISSN: 0278-0240 |
| ispartof | Disease markers, 1995-03, Vol.12 (2), p.127-133 |
| issn | 0278-0240 1875-8630 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77399751 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); Alma/SFX Local Collection |
| subjects | Alleles Arthritis, Rheumatoid - genetics Biological and medical sciences Diseases of the osteoarticular system Female HLA-DR Antigens - genetics Humans Inflammatory joint diseases Lupus Erythematosus, Systemic - genetics Male Medical sciences Polymorphism, Genetic Tumor Necrosis Factor-alpha - genetics |
| title | Increased frequency of the uncommon allele of a tumour necrosis factor alpha gene polymorphism in rheumatoid arthritis and systemic lupus erythematosus |
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