Regional cerebral hypoperfusion in long-term Type 1 (insulin-dependent) diabetic patients: Relation to hypoglycaemic events
SUMMARYRegional distribution of cerebral blood flow was determined semi-quantitatively with Tc-HMPAO brain SPET under basal conditions in Type 1 (insulin-dependent) diabetic patients of recent onset and longer disease duration, and related to metabolic control and history of hypoglycaemic events. Lo...
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| Veröffentlicht in: | Nuclear medicine communications 1995-01, Vol.16 (1), p.10-16 |
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| creator | KEYMEULEN, B JACOBS, A METZ, K DE SADELEER, C DE BOSSUYT, A SOMERS, G |
| description | SUMMARYRegional distribution of cerebral blood flow was determined semi-quantitatively with Tc-HMPAO brain SPET under basal conditions in Type 1 (insulin-dependent) diabetic patients of recent onset and longer disease duration, and related to metabolic control and history of hypoglycaemic events. Long-term diabetic patients showed significantly more alterations in regional cerebral blood flow than diabetics of recent onset and healthy controls. Regional hypoperfusion, predominantly localized in the fronto-temporal cortex, was almost exclusively observed in patients with long-term diabetes. The latter finding was related to lower HbA1c levels (i.e. better metabolic control) and to the frequency of impending hypoglycaemia, but not to age of the patient, duration of diabetes or to chronic diabetes complications. The incidence of hypoperfusion was comparable in patient groups with or without a medical history of hypoglycaemic coma. However, regions of hypoperfusion were larger in the patients who had experienced hypoglycaemic coma. It is concluded that regional cerebral hypoperfusion in long-term Type 1 (insulin-dependent) diabetics, as evidenced by HMPAO-SPET, can be related to the frequency and degree of hypoglycaemic events and to tight metabolic control, which is however at the expense of an increased risk of recurrent hypoglycaemia. |
| doi_str_mv | 10.1097/00006231-199501000-00004 |
| format | Article |
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Long-term diabetic patients showed significantly more alterations in regional cerebral blood flow than diabetics of recent onset and healthy controls. Regional hypoperfusion, predominantly localized in the fronto-temporal cortex, was almost exclusively observed in patients with long-term diabetes. The latter finding was related to lower HbA1c levels (i.e. better metabolic control) and to the frequency of impending hypoglycaemia, but not to age of the patient, duration of diabetes or to chronic diabetes complications. The incidence of hypoperfusion was comparable in patient groups with or without a medical history of hypoglycaemic coma. However, regions of hypoperfusion were larger in the patients who had experienced hypoglycaemic coma. It is concluded that regional cerebral hypoperfusion in long-term Type 1 (insulin-dependent) diabetics, as evidenced by HMPAO-SPET, can be related to the frequency and degree of hypoglycaemic events and to tight metabolic control, which is however at the expense of an increased risk of recurrent hypoglycaemia.</description><identifier>ISSN: 0143-3636</identifier><identifier>EISSN: 1473-5628</identifier><identifier>DOI: 10.1097/00006231-199501000-00004</identifier><identifier>PMID: 7609929</identifier><language>eng</language><publisher>Hagerstown, MD: Copyright Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adult ; Age of Onset ; Biological and medical sciences ; Blood Glucose - metabolism ; Brain - blood supply ; Cerebral Cortex - blood supply ; Cerebrovascular Circulation ; Cohort Studies ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - diagnostic imaging ; Diabetes Mellitus, Type 1 - physiopathology ; Glycated Hemoglobin A - analysis ; Humans ; Hypoglycemia - epidemiology ; Insulin Coma - epidemiology ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Nervous system ; Organotechnetium Compounds ; Oximes ; Prevalence ; Radionuclide Imaging ; Radionuclide investigations ; Reference Values ; Regression Analysis ; Technetium Tc 99m Exametazime</subject><ispartof>Nuclear medicine communications, 1995-01, Vol.16 (1), p.10-16</ispartof><rights>Copyright © 1995 Wolters Kluwer Health, Inc. All rights reserved.</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,4010,27904,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3418418$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7609929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KEYMEULEN, B</creatorcontrib><creatorcontrib>JACOBS, A</creatorcontrib><creatorcontrib>METZ, K DE</creatorcontrib><creatorcontrib>SADELEER, C DE</creatorcontrib><creatorcontrib>BOSSUYT, A</creatorcontrib><creatorcontrib>SOMERS, G</creatorcontrib><title>Regional cerebral hypoperfusion in long-term Type 1 (insulin-dependent) diabetic patients: Relation to hypoglycaemic events</title><title>Nuclear medicine communications</title><addtitle>Nucl Med Commun</addtitle><description>SUMMARYRegional distribution of cerebral blood flow was determined semi-quantitatively with Tc-HMPAO brain SPET under basal conditions in Type 1 (insulin-dependent) diabetic patients of recent onset and longer disease duration, and related to metabolic control and history of hypoglycaemic events. Long-term diabetic patients showed significantly more alterations in regional cerebral blood flow than diabetics of recent onset and healthy controls. Regional hypoperfusion, predominantly localized in the fronto-temporal cortex, was almost exclusively observed in patients with long-term diabetes. The latter finding was related to lower HbA1c levels (i.e. better metabolic control) and to the frequency of impending hypoglycaemia, but not to age of the patient, duration of diabetes or to chronic diabetes complications. The incidence of hypoperfusion was comparable in patient groups with or without a medical history of hypoglycaemic coma. However, regions of hypoperfusion were larger in the patients who had experienced hypoglycaemic coma. It is concluded that regional cerebral hypoperfusion in long-term Type 1 (insulin-dependent) diabetics, as evidenced by HMPAO-SPET, can be related to the frequency and degree of hypoglycaemic events and to tight metabolic control, which is however at the expense of an increased risk of recurrent hypoglycaemia.</description><subject>Adult</subject><subject>Age of Onset</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Brain - blood supply</subject><subject>Cerebral Cortex - blood supply</subject><subject>Cerebrovascular Circulation</subject><subject>Cohort Studies</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - diagnostic imaging</subject><subject>Diabetes Mellitus, Type 1 - physiopathology</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Humans</subject><subject>Hypoglycemia - epidemiology</subject><subject>Insulin Coma - epidemiology</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Organotechnetium Compounds</subject><subject>Oximes</subject><subject>Prevalence</subject><subject>Radionuclide Imaging</subject><subject>Radionuclide investigations</subject><subject>Reference Values</subject><subject>Regression Analysis</subject><subject>Technetium Tc 99m Exametazime</subject><issn>0143-3636</issn><issn>1473-5628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV9rHCEUxaU0pNu0H6HgQyntg6mOro59C6H_IFAI6bM4znXX1nGmOtOw5MvHzW73rSJ4Pfd3j3BECDN6yahWH2ldsuGMMK3XlNUb2UviGVoxoThZy6Z9jlaUCU645PIFelnKr0q0XKpzdK4k1brRK_RwC5swJhuxgwxdrsV2N40TZL-U2sAh4TimDZkhD_huNwFm-H1IZYkhkR4mSD2k-QPug-1gDg5Pdg5VKZ_wLcRaV495fDLdxJ2zMFQG_u6JV-jM21jg9fG8QD-_fL67_kZufnz9fn11QxxTUhABXPROaMdkDwwYBaWF7GjTNS2nTnrNPe07vxaNa5kF6f2aSdr0mtPWdoxfoHcH3ymPfxYosxlCcRCjTTAuxSjFtdKtqmB7AF0eS8ngzZTDYPPOMGr2uZt_uZtT7k-SqKNvjm8s3QD9afAYdO2_PfZtcTb6bJML5YRxwdq6KyYO2P0Ya-Lld1zuIZst2Dhvzf9-nT8Cd0ebpg</recordid><startdate>199501</startdate><enddate>199501</enddate><creator>KEYMEULEN, B</creator><creator>JACOBS, A</creator><creator>METZ, K DE</creator><creator>SADELEER, C DE</creator><creator>BOSSUYT, A</creator><creator>SOMERS, G</creator><general>Copyright Wolters Kluwer Health, Inc. All rights reserved</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199501</creationdate><title>Regional cerebral hypoperfusion in long-term Type 1 (insulin-dependent) diabetic patients: Relation to hypoglycaemic events</title><author>KEYMEULEN, B ; JACOBS, A ; METZ, K DE ; SADELEER, C DE ; BOSSUYT, A ; SOMERS, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1764-4e34dc49c16de1e10e7946b02b2830c6f93f0dbf542c81ae6ff51602d9308ab13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Age of Onset</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Brain - blood supply</topic><topic>Cerebral Cortex - blood supply</topic><topic>Cerebrovascular Circulation</topic><topic>Cohort Studies</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - diagnostic imaging</topic><topic>Diabetes Mellitus, Type 1 - physiopathology</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Humans</topic><topic>Hypoglycemia - epidemiology</topic><topic>Insulin Coma - epidemiology</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>Organotechnetium Compounds</topic><topic>Oximes</topic><topic>Prevalence</topic><topic>Radionuclide Imaging</topic><topic>Radionuclide investigations</topic><topic>Reference Values</topic><topic>Regression Analysis</topic><topic>Technetium Tc 99m Exametazime</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KEYMEULEN, B</creatorcontrib><creatorcontrib>JACOBS, A</creatorcontrib><creatorcontrib>METZ, K DE</creatorcontrib><creatorcontrib>SADELEER, C DE</creatorcontrib><creatorcontrib>BOSSUYT, A</creatorcontrib><creatorcontrib>SOMERS, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nuclear medicine communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KEYMEULEN, B</au><au>JACOBS, A</au><au>METZ, K DE</au><au>SADELEER, C DE</au><au>BOSSUYT, A</au><au>SOMERS, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional cerebral hypoperfusion in long-term Type 1 (insulin-dependent) diabetic patients: Relation to hypoglycaemic events</atitle><jtitle>Nuclear medicine communications</jtitle><addtitle>Nucl Med Commun</addtitle><date>1995-01</date><risdate>1995</risdate><volume>16</volume><issue>1</issue><spage>10</spage><epage>16</epage><pages>10-16</pages><issn>0143-3636</issn><eissn>1473-5628</eissn><abstract>SUMMARYRegional distribution of cerebral blood flow was determined semi-quantitatively with Tc-HMPAO brain SPET under basal conditions in Type 1 (insulin-dependent) diabetic patients of recent onset and longer disease duration, and related to metabolic control and history of hypoglycaemic events. Long-term diabetic patients showed significantly more alterations in regional cerebral blood flow than diabetics of recent onset and healthy controls. Regional hypoperfusion, predominantly localized in the fronto-temporal cortex, was almost exclusively observed in patients with long-term diabetes. The latter finding was related to lower HbA1c levels (i.e. better metabolic control) and to the frequency of impending hypoglycaemia, but not to age of the patient, duration of diabetes or to chronic diabetes complications. The incidence of hypoperfusion was comparable in patient groups with or without a medical history of hypoglycaemic coma. However, regions of hypoperfusion were larger in the patients who had experienced hypoglycaemic coma. It is concluded that regional cerebral hypoperfusion in long-term Type 1 (insulin-dependent) diabetics, as evidenced by HMPAO-SPET, can be related to the frequency and degree of hypoglycaemic events and to tight metabolic control, which is however at the expense of an increased risk of recurrent hypoglycaemia.</abstract><cop>Hagerstown, MD</cop><pub>Copyright Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>7609929</pmid><doi>10.1097/00006231-199501000-00004</doi><tpages>7</tpages></addata></record> |
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| ispartof | Nuclear medicine communications, 1995-01, Vol.16 (1), p.10-16 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Age of Onset Biological and medical sciences Blood Glucose - metabolism Brain - blood supply Cerebral Cortex - blood supply Cerebrovascular Circulation Cohort Studies Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - diagnostic imaging Diabetes Mellitus, Type 1 - physiopathology Glycated Hemoglobin A - analysis Humans Hypoglycemia - epidemiology Insulin Coma - epidemiology Investigative techniques, diagnostic techniques (general aspects) Medical sciences Nervous system Organotechnetium Compounds Oximes Prevalence Radionuclide Imaging Radionuclide investigations Reference Values Regression Analysis Technetium Tc 99m Exametazime |
| title | Regional cerebral hypoperfusion in long-term Type 1 (insulin-dependent) diabetic patients: Relation to hypoglycaemic events |
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