Ambulatory oesophageal bile reflux monitoring in Barrett's oesophagus
Bile reflux has been implicated in the pathogenesis of Barrett's oesophagus but evaluation remains difficult. Bilitec 2000 is an ambulatory system that detects bilirubin based on its spectrophotometric properties. Oesophageal bile exposure was evaluated in three groups of patients. Group 1 (n =...
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| Veröffentlicht in: | British journal of surgery 1995-05, Vol.82 (5), p.657-660 |
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| container_end_page | 660 |
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| container_title | British journal of surgery |
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| creator | Caldwell, M. T. P. Lawlor, P. Byrne, P. J. Walsh, T. N. Hennessy, T. P. J. |
| description | Bile reflux has been implicated in the pathogenesis of Barrett's oesophagus but evaluation remains difficult. Bilitec 2000 is an ambulatory system that detects bilirubin based on its spectrophotometric properties. Oesophageal bile exposure was evaluated in three groups of patients. Group 1 (n = 11) were normal controls, group 2 (n = 13) were patients with uncomplicated gastro‐oesophageal reflux and group 3 (n = 12) were patients with Barrett's oesophagus. Bile reflux was greater in patients with Barrett's mucosa than in controls or those with uncomplicated reflux. This difference was seen in the supine and interdigestive periods. The percentage of time at which gastric pH was greater than 4 and oesophageal pH was above 7 did not differ between the groups. Bilitec 2000 detects greater bile reflux in patients with Barrett's oesophagus. No corresponding gastric or oesophageal alkaline shift is found. This ambulatory bile reflux monitoring system may be a useful tool in clinical practice. |
| doi_str_mv | 10.1002/bjs.1800820528 |
| format | Article |
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T. P. ; Lawlor, P. ; Byrne, P. J. ; Walsh, T. N. ; Hennessy, T. P. J.</creator><creatorcontrib>Caldwell, M. T. P. ; Lawlor, P. ; Byrne, P. J. ; Walsh, T. N. ; Hennessy, T. P. J.</creatorcontrib><description>Bile reflux has been implicated in the pathogenesis of Barrett's oesophagus but evaluation remains difficult. Bilitec 2000 is an ambulatory system that detects bilirubin based on its spectrophotometric properties. Oesophageal bile exposure was evaluated in three groups of patients. Group 1 (n = 11) were normal controls, group 2 (n = 13) were patients with uncomplicated gastro‐oesophageal reflux and group 3 (n = 12) were patients with Barrett's oesophagus. Bile reflux was greater in patients with Barrett's mucosa than in controls or those with uncomplicated reflux. This difference was seen in the supine and interdigestive periods. The percentage of time at which gastric pH was greater than 4 and oesophageal pH was above 7 did not differ between the groups. Bilitec 2000 detects greater bile reflux in patients with Barrett's oesophagus. No corresponding gastric or oesophageal alkaline shift is found. This ambulatory bile reflux monitoring system may be a useful tool in clinical practice.</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.1800820528</identifier><identifier>PMID: 7613943</identifier><language>eng</language><publisher>Bristol: John Wiley & Sons, Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Ambulatory Care ; Barrett Esophagus - complications ; Bile - chemistry ; Bilirubin - analysis ; Controlled Clinical Trials as Topic ; Esophagus - chemistry ; Gastroesophageal Reflux - complications ; Humans ; Hydrogen-Ion Concentration ; Middle Aged ; Spectrophotometry, Atomic</subject><ispartof>British journal of surgery, 1995-05, Vol.82 (5), p.657-660</ispartof><rights>Copyright © 1995 British Journal of Surgery Society Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2548-f0b06f2e730a578f9982455b111e265b3f1e307553dd1b54386696d14f5366eb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.1800820528$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.1800820528$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7613943$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caldwell, M. 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This difference was seen in the supine and interdigestive periods. The percentage of time at which gastric pH was greater than 4 and oesophageal pH was above 7 did not differ between the groups. Bilitec 2000 detects greater bile reflux in patients with Barrett's oesophagus. No corresponding gastric or oesophageal alkaline shift is found. This ambulatory bile reflux monitoring system may be a useful tool in clinical practice.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Ambulatory Care</subject><subject>Barrett Esophagus - complications</subject><subject>Bile - chemistry</subject><subject>Bilirubin - analysis</subject><subject>Controlled Clinical Trials as Topic</subject><subject>Esophagus - chemistry</subject><subject>Gastroesophageal Reflux - complications</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Middle Aged</subject><subject>Spectrophotometry, Atomic</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1PwkAUxDdGg4hevZn0pKfi233djx6BIGpQ41c4bnZhi8WWYreN8N9bA4HTy2R-85IZQi4pdCkAu7UL36UKQDHgTB2RNkXBQ0aFOiZtAJAhRYan5Mz7BQDFhmqRlhQU4wjbZNjLbZ2Zqig3QeF8sfoyc2eywKaZC0qXZPU6yItl2gDpch6ky6BvytJV1Y3f87U_JyeJyby72N0O-bwbfgzuw_HL6GHQG4dTxiMVJmBBJMxJBMOlSuJYsYhzSyl1THCLCXUIknOczajlESohYjGjUcJRCGexQ663f1dl8VM7X-k89VOXZWbpitprKTHmimEDXu3A2uZupldlmptyo3e9Gz_e-r9Nz83epqD_R9XNqPowqu4_vh9Ukw232dRXbr3PmvJbC4mS68nzSMcj6MeTt1f9hH8xU3jg</recordid><startdate>199505</startdate><enddate>199505</enddate><creator>Caldwell, M. 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N.</creatorcontrib><creatorcontrib>Hennessy, T. P. J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caldwell, M. T. P.</au><au>Lawlor, P.</au><au>Byrne, P. J.</au><au>Walsh, T. N.</au><au>Hennessy, T. P. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ambulatory oesophageal bile reflux monitoring in Barrett's oesophagus</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>1995-05</date><risdate>1995</risdate><volume>82</volume><issue>5</issue><spage>657</spage><epage>660</epage><pages>657-660</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><abstract>Bile reflux has been implicated in the pathogenesis of Barrett's oesophagus but evaluation remains difficult. Bilitec 2000 is an ambulatory system that detects bilirubin based on its spectrophotometric properties. Oesophageal bile exposure was evaluated in three groups of patients. Group 1 (n = 11) were normal controls, group 2 (n = 13) were patients with uncomplicated gastro‐oesophageal reflux and group 3 (n = 12) were patients with Barrett's oesophagus. Bile reflux was greater in patients with Barrett's mucosa than in controls or those with uncomplicated reflux. This difference was seen in the supine and interdigestive periods. The percentage of time at which gastric pH was greater than 4 and oesophageal pH was above 7 did not differ between the groups. Bilitec 2000 detects greater bile reflux in patients with Barrett's oesophagus. No corresponding gastric or oesophageal alkaline shift is found. This ambulatory bile reflux monitoring system may be a useful tool in clinical practice.</abstract><cop>Bristol</cop><pub>John Wiley & Sons, Ltd</pub><pmid>7613943</pmid><doi>10.1002/bjs.1800820528</doi><tpages>4</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Aged Ambulatory Care Barrett Esophagus - complications Bile - chemistry Bilirubin - analysis Controlled Clinical Trials as Topic Esophagus - chemistry Gastroesophageal Reflux - complications Humans Hydrogen-Ion Concentration Middle Aged Spectrophotometry, Atomic |
| title | Ambulatory oesophageal bile reflux monitoring in Barrett's oesophagus |
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