Sex differences in acetaldehyde on body temperature and open-field performance in the rat
Using the open field, for making an overall assessment of behavioural change in response to acetaldehyde (AcH) treatment, the results from the present study demonstrate that AcH produces behavioural and physiological effects similar to those of ethanol. High doses of AcH produced a similar degree of...
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| Veröffentlicht in: | Drug and alcohol dependence 1987, Vol.19 (1), p.1-6 |
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| container_title | Drug and alcohol dependence |
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| creator | Myers, Wendy D. Gibson, Stephen Ng, Kim T. Singer, George |
| description | Using the open field, for making an overall assessment of behavioural change in response to acetaldehyde (AcH) treatment, the results from the present study demonstrate that AcH produces behavioural and physiological effects similar to those of ethanol.
High doses of AcH produced a similar degree of change as high doses of ethanol. Both compounds render the animal incapable of locomotor activities, such as ambulation and rearing and both produce a decrease of 2–3 °C in body temperature. AcH, however, appears to be a much more potent compound as behavioural and physiological changes are exhibited even after a dose of 10 mg/kg, while the dose of ethanol necessary to produce a decrease in open-field behaviour is at least 10 times as much. Females were more sensitive to the effects of AcH at the 100 mg/kg dose. |
| doi_str_mv | 10.1016/0376-8716(87)90081-0 |
| format | Article |
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High doses of AcH produced a similar degree of change as high doses of ethanol. Both compounds render the animal incapable of locomotor activities, such as ambulation and rearing and both produce a decrease of 2–3 °C in body temperature. AcH, however, appears to be a much more potent compound as behavioural and physiological changes are exhibited even after a dose of 10 mg/kg, while the dose of ethanol necessary to produce a decrease in open-field behaviour is at least 10 times as much. Females were more sensitive to the effects of AcH at the 100 mg/kg dose.</description><identifier>ISSN: 0376-8716</identifier><identifier>EISSN: 1879-0046</identifier><identifier>DOI: 10.1016/0376-8716(87)90081-0</identifier><identifier>PMID: 3816535</identifier><identifier>CODEN: DADEDV</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Acetaldehyde ; Acetaldehyde - pharmacology ; Alcoholism and acute alcohol poisoning ; Animals ; Biological and medical sciences ; Body Temperature - drug effects ; Female ; Male ; Medical sciences ; Motor Activity - drug effects ; Open field ; Rats ; Reaction Time - drug effects ; Sex difference ; Sex Factors ; Temperature ; Toxicology</subject><ispartof>Drug and alcohol dependence, 1987, Vol.19 (1), p.1-6</ispartof><rights>1987</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-6627d65ef77f347000e255ad9574a64279f60878eebe583f31e5fcf18a78dbe73</citedby><cites>FETCH-LOGICAL-c386t-6627d65ef77f347000e255ad9574a64279f60878eebe583f31e5fcf18a78dbe73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0376-8716(87)90081-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4022,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8165297$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3816535$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Myers, Wendy D.</creatorcontrib><creatorcontrib>Gibson, Stephen</creatorcontrib><creatorcontrib>Ng, Kim T.</creatorcontrib><creatorcontrib>Singer, George</creatorcontrib><title>Sex differences in acetaldehyde on body temperature and open-field performance in the rat</title><title>Drug and alcohol dependence</title><addtitle>Drug Alcohol Depend</addtitle><description>Using the open field, for making an overall assessment of behavioural change in response to acetaldehyde (AcH) treatment, the results from the present study demonstrate that AcH produces behavioural and physiological effects similar to those of ethanol.
High doses of AcH produced a similar degree of change as high doses of ethanol. Both compounds render the animal incapable of locomotor activities, such as ambulation and rearing and both produce a decrease of 2–3 °C in body temperature. AcH, however, appears to be a much more potent compound as behavioural and physiological changes are exhibited even after a dose of 10 mg/kg, while the dose of ethanol necessary to produce a decrease in open-field behaviour is at least 10 times as much. Females were more sensitive to the effects of AcH at the 100 mg/kg dose.</description><subject>Acetaldehyde</subject><subject>Acetaldehyde - pharmacology</subject><subject>Alcoholism and acute alcohol poisoning</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Temperature - drug effects</subject><subject>Female</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Motor Activity - drug effects</subject><subject>Open field</subject><subject>Rats</subject><subject>Reaction Time - drug effects</subject><subject>Sex difference</subject><subject>Sex Factors</subject><subject>Temperature</subject><subject>Toxicology</subject><issn>0376-8716</issn><issn>1879-0046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotVb_gUIOInpYTZrNx14EEb9A8KAePIU0mdDIftRkK_bfm7WlR3OYwMwzw8uD0DEll5RQcUWYFIWSVJwreVERomhBdtCYKlkVhJRiF423yD46SOmT5CcqMkIjpqjgjI_Rxyv8YBe8hwithYRDi42F3tQO5isHuGvxrHMr3EOzgGj6ZQRsWoe7BbSFD1A7nPu-i43J-8N6PwecwUO0502d4GjzT9D7_d3b7WPx_PLwdHvzXFimRF8IMZVOcPBSelbKnBCmnBtXcVkaUU5l5QVRUgHMgCvmGQXurafKSOVmINkEna3vLmL3tYTU6yYkC3VtWuiWSUvJKi6oyGC5Bm3sUorg9SKGxsSVpkQPRvWgSw-6ctF_RnNrgk4295ezBtx2aaMwz083c5OsqX3MHkLaYgM1rYaY12sMsovvAFEnGwblLkSwvXZd-D_HL76skb4</recordid><startdate>1987</startdate><enddate>1987</enddate><creator>Myers, Wendy D.</creator><creator>Gibson, Stephen</creator><creator>Ng, Kim T.</creator><creator>Singer, George</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1987</creationdate><title>Sex differences in acetaldehyde on body temperature and open-field performance in the rat</title><author>Myers, Wendy D. ; Gibson, Stephen ; Ng, Kim T. ; Singer, George</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-6627d65ef77f347000e255ad9574a64279f60878eebe583f31e5fcf18a78dbe73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Acetaldehyde</topic><topic>Acetaldehyde - pharmacology</topic><topic>Alcoholism and acute alcohol poisoning</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Temperature - drug effects</topic><topic>Female</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Motor Activity - drug effects</topic><topic>Open field</topic><topic>Rats</topic><topic>Reaction Time - drug effects</topic><topic>Sex difference</topic><topic>Sex Factors</topic><topic>Temperature</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Myers, Wendy D.</creatorcontrib><creatorcontrib>Gibson, Stephen</creatorcontrib><creatorcontrib>Ng, Kim T.</creatorcontrib><creatorcontrib>Singer, George</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Drug and alcohol dependence</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Myers, Wendy D.</au><au>Gibson, Stephen</au><au>Ng, Kim T.</au><au>Singer, George</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex differences in acetaldehyde on body temperature and open-field performance in the rat</atitle><jtitle>Drug and alcohol dependence</jtitle><addtitle>Drug Alcohol Depend</addtitle><date>1987</date><risdate>1987</risdate><volume>19</volume><issue>1</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>0376-8716</issn><eissn>1879-0046</eissn><coden>DADEDV</coden><abstract>Using the open field, for making an overall assessment of behavioural change in response to acetaldehyde (AcH) treatment, the results from the present study demonstrate that AcH produces behavioural and physiological effects similar to those of ethanol.
High doses of AcH produced a similar degree of change as high doses of ethanol. Both compounds render the animal incapable of locomotor activities, such as ambulation and rearing and both produce a decrease of 2–3 °C in body temperature. AcH, however, appears to be a much more potent compound as behavioural and physiological changes are exhibited even after a dose of 10 mg/kg, while the dose of ethanol necessary to produce a decrease in open-field behaviour is at least 10 times as much. Females were more sensitive to the effects of AcH at the 100 mg/kg dose.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>3816535</pmid><doi>10.1016/0376-8716(87)90081-0</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0376-8716 |
| ispartof | Drug and alcohol dependence, 1987, Vol.19 (1), p.1-6 |
| issn | 0376-8716 1879-0046 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acetaldehyde Acetaldehyde - pharmacology Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Body Temperature - drug effects Female Male Medical sciences Motor Activity - drug effects Open field Rats Reaction Time - drug effects Sex difference Sex Factors Temperature Toxicology |
| title | Sex differences in acetaldehyde on body temperature and open-field performance in the rat |
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