Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells. A possible signaling role for the Syk tyrosine kinase

Activation of cytoplasmic tyrosine kinases is an important aspect of signal transduction mediated by integrins. In the human monocytic cell line THP-1, either integrin-dependent cell adhesion to fibronectin or ligation of beta 1 integrins with antibodies causes a rapid and intense tyrosine phosphory...

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Veröffentlicht in:	The Journal of biological chemistry 1995-07, Vol.270 (27), p.16189-16197
Hauptverfasser:	Lin, T H, Rosales, C, Mondal, K, Bolen, J B, Haskill, S, Juliano, R L
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzoquinones Cell Adhesion - physiology Cell Adhesion Molecules - metabolism Enzyme Activation Enzyme Precursors - antagonists & inhibitors Enzyme Precursors - metabolism Extracellular Matrix Proteins - metabolism Fibronectins - metabolism Focal Adhesion Kinase 1 Focal Adhesion Protein-Tyrosine Kinases Gene Expression Regulation, Neoplastic Genes, Reporter Genistein Humans Inflammation Integrin beta1 Integrins - metabolism Interleukin-1 - biosynthesis Interleukin-1 - genetics Intracellular Signaling Peptides and Proteins Isoflavones - pharmacology Lactams, Macrocyclic Leukemia, Monocytic, Acute Monocytes - metabolism NF-kappa B - metabolism Phosphorylation Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - metabolism Quinones - pharmacology Rifabutin - analogs & derivatives RNA, Messenger - biosynthesis Signal Transduction Syk Kinase Tumor Cells, Cultured Tyrosine - metabolism
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