P3 Abnormality in fragile X syndrome
P300 (P3) and other long latency auditory event-related potentials (ERPs) were recorded in 33 adults with fragile X syndrome. All patients had an abnormal P3. It was longer in latency and smaller in amplitude than in controls. In several cases, it was split into two separate components, and in other...
Gespeichert in:
| Veröffentlicht in: | Biological psychiatry (1969) 1987-03, Vol.22 (3), p.303-312 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 312 |
|---|---|
| container_issue | 3 |
| container_start_page | 303 |
| container_title | Biological psychiatry (1969) |
| container_volume | 22 |
| creator | St. Clair, David M. Blackwood, Douglas H.R. Oliver, Christopher J. Dickens, Paul |
| description | P300 (P3) and other long latency auditory event-related potentials (ERPs) were recorded in 33 adults with fragile X syndrome. All patients had an abnormal P3. It was longer in latency and smaller in amplitude than in controls. In several cases, it was split into two separate components, and in others, was generated in response to expected as well as unexpected events. Abnormal P3 was not related to age, percentage cell fragility, or intellectual ability, but complete splitting was associated with the presence of physical dysmorphisms. Our results are interpreted as showing that in fragile X syndrome there is dysgenesis of the hippocampus and related brain structures. |
| doi_str_mv | 10.1016/0006-3223(87)90148-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77391086</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>000632238790148X</els_id><sourcerecordid>77391086</sourcerecordid><originalsourceid>FETCH-LOGICAL-c437t-a35e82e01b2252624343ce3037e65b83e9b8e50a82a4cdf6e83be4f09a223df43</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMotVb_gcIeRPSwmkyym-xFKMUvKOhBobeQzc5KZD9qshX6701t6dHTMMwzw7wPIeeM3jLK8jtKaZ5yAH6t5E1BmVDp4oCMmZI8BUHhkIz3yDE5CeErthKAjcgIClFIxcbk8o0n07LrfWsaN6wT1yW1N5-uwWSRhHVX-b7FU3JUmybg2a5OyMfjw_vsOZ2_Pr3MpvPUCi6H1PAMFSBlJUAGOQguuEVOucQ8KxXHolSYUaPACFvVOSpeoqhpYeKHVS34hFxt7y59_73CMOjWBYtNYzrsV0FLyQtGVR5BsQWt70PwWOuld63xa82o3sjRm-R6k1wrqf_k6EVcu9jdX5UtVvulnY04v9zNTbCmiSI668IeUyAyyiBi91sMo4sfh14H67CzWDmPdtBV7_7_4xdZnH2c</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77391086</pqid></control><display><type>article</type><title>P3 Abnormality in fragile X syndrome</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>St. Clair, David M. ; Blackwood, Douglas H.R. ; Oliver, Christopher J. ; Dickens, Paul</creator><creatorcontrib>St. Clair, David M. ; Blackwood, Douglas H.R. ; Oliver, Christopher J. ; Dickens, Paul</creatorcontrib><description>P300 (P3) and other long latency auditory event-related potentials (ERPs) were recorded in 33 adults with fragile X syndrome. All patients had an abnormal P3. It was longer in latency and smaller in amplitude than in controls. In several cases, it was split into two separate components, and in others, was generated in response to expected as well as unexpected events. Abnormal P3 was not related to age, percentage cell fragility, or intellectual ability, but complete splitting was associated with the presence of physical dysmorphisms. Our results are interpreted as showing that in fragile X syndrome there is dysgenesis of the hippocampus and related brain structures.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/0006-3223(87)90148-X</identifier><identifier>PMID: 2949781</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Chromosome fragility (bloom syndrome, ataxia telangiectasia, fanconi anemia, x-linked mental retardation...) ; Down Syndrome - physiopathology ; Evoked Potentials, Auditory ; Female ; Fragile X Syndrome - physiopathology ; Humans ; Male ; Medical genetics ; Medical sciences ; Middle Aged ; Reaction Time ; Sex Chromosome Aberrations - physiopathology</subject><ispartof>Biological psychiatry (1969), 1987-03, Vol.22 (3), p.303-312</ispartof><rights>1987</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-a35e82e01b2252624343ce3037e65b83e9b8e50a82a4cdf6e83be4f09a223df43</citedby><cites>FETCH-LOGICAL-c437t-a35e82e01b2252624343ce3037e65b83e9b8e50a82a4cdf6e83be4f09a223df43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-3223(87)90148-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8245012$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2949781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>St. Clair, David M.</creatorcontrib><creatorcontrib>Blackwood, Douglas H.R.</creatorcontrib><creatorcontrib>Oliver, Christopher J.</creatorcontrib><creatorcontrib>Dickens, Paul</creatorcontrib><title>P3 Abnormality in fragile X syndrome</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>P300 (P3) and other long latency auditory event-related potentials (ERPs) were recorded in 33 adults with fragile X syndrome. All patients had an abnormal P3. It was longer in latency and smaller in amplitude than in controls. In several cases, it was split into two separate components, and in others, was generated in response to expected as well as unexpected events. Abnormal P3 was not related to age, percentage cell fragility, or intellectual ability, but complete splitting was associated with the presence of physical dysmorphisms. Our results are interpreted as showing that in fragile X syndrome there is dysgenesis of the hippocampus and related brain structures.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Chromosome fragility (bloom syndrome, ataxia telangiectasia, fanconi anemia, x-linked mental retardation...)</subject><subject>Down Syndrome - physiopathology</subject><subject>Evoked Potentials, Auditory</subject><subject>Female</subject><subject>Fragile X Syndrome - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Reaction Time</subject><subject>Sex Chromosome Aberrations - physiopathology</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotVb_gcIeRPSwmkyym-xFKMUvKOhBobeQzc5KZD9qshX6701t6dHTMMwzw7wPIeeM3jLK8jtKaZ5yAH6t5E1BmVDp4oCMmZI8BUHhkIz3yDE5CeErthKAjcgIClFIxcbk8o0n07LrfWsaN6wT1yW1N5-uwWSRhHVX-b7FU3JUmybg2a5OyMfjw_vsOZ2_Pr3MpvPUCi6H1PAMFSBlJUAGOQguuEVOucQ8KxXHolSYUaPACFvVOSpeoqhpYeKHVS34hFxt7y59_73CMOjWBYtNYzrsV0FLyQtGVR5BsQWt70PwWOuld63xa82o3sjRm-R6k1wrqf_k6EVcu9jdX5UtVvulnY04v9zNTbCmiSI668IeUyAyyiBi91sMo4sfh14H67CzWDmPdtBV7_7_4xdZnH2c</recordid><startdate>19870301</startdate><enddate>19870301</enddate><creator>St. Clair, David M.</creator><creator>Blackwood, Douglas H.R.</creator><creator>Oliver, Christopher J.</creator><creator>Dickens, Paul</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870301</creationdate><title>P3 Abnormality in fragile X syndrome</title><author>St. Clair, David M. ; Blackwood, Douglas H.R. ; Oliver, Christopher J. ; Dickens, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-a35e82e01b2252624343ce3037e65b83e9b8e50a82a4cdf6e83be4f09a223df43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Chromosome fragility (bloom syndrome, ataxia telangiectasia, fanconi anemia, x-linked mental retardation...)</topic><topic>Down Syndrome - physiopathology</topic><topic>Evoked Potentials, Auditory</topic><topic>Female</topic><topic>Fragile X Syndrome - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Reaction Time</topic><topic>Sex Chromosome Aberrations - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>St. Clair, David M.</creatorcontrib><creatorcontrib>Blackwood, Douglas H.R.</creatorcontrib><creatorcontrib>Oliver, Christopher J.</creatorcontrib><creatorcontrib>Dickens, Paul</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>St. Clair, David M.</au><au>Blackwood, Douglas H.R.</au><au>Oliver, Christopher J.</au><au>Dickens, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>P3 Abnormality in fragile X syndrome</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>1987-03-01</date><risdate>1987</risdate><volume>22</volume><issue>3</issue><spage>303</spage><epage>312</epage><pages>303-312</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>P300 (P3) and other long latency auditory event-related potentials (ERPs) were recorded in 33 adults with fragile X syndrome. All patients had an abnormal P3. It was longer in latency and smaller in amplitude than in controls. In several cases, it was split into two separate components, and in others, was generated in response to expected as well as unexpected events. Abnormal P3 was not related to age, percentage cell fragility, or intellectual ability, but complete splitting was associated with the presence of physical dysmorphisms. Our results are interpreted as showing that in fragile X syndrome there is dysgenesis of the hippocampus and related brain structures.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2949781</pmid><doi>10.1016/0006-3223(87)90148-X</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-3223 |
| ispartof | Biological psychiatry (1969), 1987-03, Vol.22 (3), p.303-312 |
| issn | 0006-3223 1873-2402 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77391086 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adolescent Adult Aged Biological and medical sciences Chromosome fragility (bloom syndrome, ataxia telangiectasia, fanconi anemia, x-linked mental retardation...) Down Syndrome - physiopathology Evoked Potentials, Auditory Female Fragile X Syndrome - physiopathology Humans Male Medical genetics Medical sciences Middle Aged Reaction Time Sex Chromosome Aberrations - physiopathology |
| title | P3 Abnormality in fragile X syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T11%3A19%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=P3%20Abnormality%20in%20fragile%20X%20syndrome&rft.jtitle=Biological%20psychiatry%20(1969)&rft.au=St.%20Clair,%20David%20M.&rft.date=1987-03-01&rft.volume=22&rft.issue=3&rft.spage=303&rft.epage=312&rft.pages=303-312&rft.issn=0006-3223&rft.eissn=1873-2402&rft.coden=BIPCBF&rft_id=info:doi/10.1016/0006-3223(87)90148-X&rft_dat=%3Cproquest_cross%3E77391086%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77391086&rft_id=info:pmid/2949781&rft_els_id=000632238790148X&rfr_iscdi=true |