Effects of methysergide and ritanserin on the prolactin and thyrotropin responses to TRH in depressed patients
Despite extensive study of the effects of various pharmacological agents on the thyrotropin (TSH) and prolactin (PRL) responses to TRH challenge, the effect of serotoninergic agents remains inconclusive. We studied the effect of the serotonin antagonists methysergide (non-selective 5-HT 1/5-HT 2 blo...
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| Veröffentlicht in: | European neuropsychopharmacology 1995-03, Vol.5 (1), p.15-18 |
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| container_title | European neuropsychopharmacology |
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| creator | Papakostas, Yiannis G. Markianos, Manolis Papadimitriou, George N. Zervas, Iannis M. Stefanis, Costas N. |
| description | Despite extensive study of the effects of various pharmacological agents on the thyrotropin (TSH) and prolactin (PRL) responses to TRH challenge, the effect of serotoninergic agents remains inconclusive. We studied the effect of the serotonin antagonists methysergide (non-selective 5-HT
1/5-HT
2 blocker with dopaminergic properties) and ritanserin (selective 5-HT
2 blocker) on the TSH and PRL responses to TRH stimulation in two groups of medication-free female depressed patients in a double-blind, within-subject design. Methysergide was found to decrease significantly the PRL response to TRH, while ritanserin had no effect. Neither compound influenced the TSH response. Results suggest that 5-HT
2 mechanisms do not mediate the PRL and TSH responses to TRH challenge in depression. The reduction in PRL observed after methysergide is probably due to either 5-HT
1 or dopaminergic mechanisms. |
| doi_str_mv | 10.1016/0924-977X(94)00126-V |
| format | Article |
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1/5-HT
2 blocker with dopaminergic properties) and ritanserin (selective 5-HT
2 blocker) on the TSH and PRL responses to TRH stimulation in two groups of medication-free female depressed patients in a double-blind, within-subject design. Methysergide was found to decrease significantly the PRL response to TRH, while ritanserin had no effect. Neither compound influenced the TSH response. Results suggest that 5-HT
2 mechanisms do not mediate the PRL and TSH responses to TRH challenge in depression. The reduction in PRL observed after methysergide is probably due to either 5-HT
1 or dopaminergic mechanisms.</description><identifier>ISSN: 0924-977X</identifier><identifier>EISSN: 1873-7862</identifier><identifier>DOI: 10.1016/0924-977X(94)00126-V</identifier><identifier>PMID: 7613098</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Aged ; Depression ; Female ; Humans ; Methysergide ; Methysergide - pharmacology ; Middle Aged ; Prolactin ; Prolactin - metabolism ; Ritanserin ; Ritanserin - pharmacology ; Thyrotropin - metabolism ; Thyrotropin releasing hormone</subject><ispartof>European neuropsychopharmacology, 1995-03, Vol.5 (1), p.15-18</ispartof><rights>1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0924-977X(94)00126-V$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7613098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Papakostas, Yiannis G.</creatorcontrib><creatorcontrib>Markianos, Manolis</creatorcontrib><creatorcontrib>Papadimitriou, George N.</creatorcontrib><creatorcontrib>Zervas, Iannis M.</creatorcontrib><creatorcontrib>Stefanis, Costas N.</creatorcontrib><title>Effects of methysergide and ritanserin on the prolactin and thyrotropin responses to TRH in depressed patients</title><title>European neuropsychopharmacology</title><addtitle>Eur Neuropsychopharmacol</addtitle><description>Despite extensive study of the effects of various pharmacological agents on the thyrotropin (TSH) and prolactin (PRL) responses to TRH challenge, the effect of serotoninergic agents remains inconclusive. We studied the effect of the serotonin antagonists methysergide (non-selective 5-HT
1/5-HT
2 blocker with dopaminergic properties) and ritanserin (selective 5-HT
2 blocker) on the TSH and PRL responses to TRH stimulation in two groups of medication-free female depressed patients in a double-blind, within-subject design. Methysergide was found to decrease significantly the PRL response to TRH, while ritanserin had no effect. Neither compound influenced the TSH response. Results suggest that 5-HT
2 mechanisms do not mediate the PRL and TSH responses to TRH challenge in depression. The reduction in PRL observed after methysergide is probably due to either 5-HT
1 or dopaminergic mechanisms.</description><subject>Aged</subject><subject>Depression</subject><subject>Female</subject><subject>Humans</subject><subject>Methysergide</subject><subject>Methysergide - pharmacology</subject><subject>Middle Aged</subject><subject>Prolactin</subject><subject>Prolactin - metabolism</subject><subject>Ritanserin</subject><subject>Ritanserin - pharmacology</subject><subject>Thyrotropin - metabolism</subject><subject>Thyrotropin releasing hormone</subject><issn>0924-977X</issn><issn>1873-7862</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LJDEQhoO46PjxDxRyEj30btLpSToXQUR3FoSFRcVbyCQVjcx02iQj-O-tcQaPewp566lK6iHkhLOfnHH5i-m2a7RST-e6u2CMt7J53CET3ivRqF62u2TyjeyTg1JeEZoKoffInpJcMN1PyHATArhaaAp0CfXlo0B-jh6oHTzNsdoBgzjQNND6AnTMaWFdxWBdRzynmtOI9wxlTAgXWhO9_zejmHkYMS7g6WhrhKGWI_Ij2EWB4-15SB5ub-6vZ83d399_rq_uGieYrI30ft5ZJRVjbcunrJ06B70QHJezzHZBqTm3TgbpMVOd08IGoeY6TNsWTYhDcraZix9-W0GpZhmLg8XCDpBWxSglet1LgWC3AV1OpWQIZsxxafOH4cysNZu1Q7N2aHRnvjSbR2w73c5fzZfgv5u2XrF-uakDLvkeIZviUIADHzPqNj7F_z_wCQGYjhM</recordid><startdate>19950301</startdate><enddate>19950301</enddate><creator>Papakostas, Yiannis G.</creator><creator>Markianos, Manolis</creator><creator>Papadimitriou, George N.</creator><creator>Zervas, Iannis M.</creator><creator>Stefanis, Costas N.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950301</creationdate><title>Effects of methysergide and ritanserin on the prolactin and thyrotropin responses to TRH in depressed patients</title><author>Papakostas, Yiannis G. ; Markianos, Manolis ; Papadimitriou, George N. ; Zervas, Iannis M. ; Stefanis, Costas N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c306t-6ddb4a767002215025cce8331187a0a4f77b1ac6f6d31174c93af37b9f5220123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Aged</topic><topic>Depression</topic><topic>Female</topic><topic>Humans</topic><topic>Methysergide</topic><topic>Methysergide - pharmacology</topic><topic>Middle Aged</topic><topic>Prolactin</topic><topic>Prolactin - metabolism</topic><topic>Ritanserin</topic><topic>Ritanserin - pharmacology</topic><topic>Thyrotropin - metabolism</topic><topic>Thyrotropin releasing hormone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Papakostas, Yiannis G.</creatorcontrib><creatorcontrib>Markianos, Manolis</creatorcontrib><creatorcontrib>Papadimitriou, George N.</creatorcontrib><creatorcontrib>Zervas, Iannis M.</creatorcontrib><creatorcontrib>Stefanis, Costas N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European neuropsychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Papakostas, Yiannis G.</au><au>Markianos, Manolis</au><au>Papadimitriou, George N.</au><au>Zervas, Iannis M.</au><au>Stefanis, Costas N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of methysergide and ritanserin on the prolactin and thyrotropin responses to TRH in depressed patients</atitle><jtitle>European neuropsychopharmacology</jtitle><addtitle>Eur Neuropsychopharmacol</addtitle><date>1995-03-01</date><risdate>1995</risdate><volume>5</volume><issue>1</issue><spage>15</spage><epage>18</epage><pages>15-18</pages><issn>0924-977X</issn><eissn>1873-7862</eissn><abstract>Despite extensive study of the effects of various pharmacological agents on the thyrotropin (TSH) and prolactin (PRL) responses to TRH challenge, the effect of serotoninergic agents remains inconclusive. We studied the effect of the serotonin antagonists methysergide (non-selective 5-HT
1/5-HT
2 blocker with dopaminergic properties) and ritanserin (selective 5-HT
2 blocker) on the TSH and PRL responses to TRH stimulation in two groups of medication-free female depressed patients in a double-blind, within-subject design. Methysergide was found to decrease significantly the PRL response to TRH, while ritanserin had no effect. Neither compound influenced the TSH response. Results suggest that 5-HT
2 mechanisms do not mediate the PRL and TSH responses to TRH challenge in depression. The reduction in PRL observed after methysergide is probably due to either 5-HT
1 or dopaminergic mechanisms.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>7613098</pmid><doi>10.1016/0924-977X(94)00126-V</doi><tpages>4</tpages></addata></record> |
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| ispartof | European neuropsychopharmacology, 1995-03, Vol.5 (1), p.15-18 |
| issn | 0924-977X 1873-7862 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Aged Depression Female Humans Methysergide Methysergide - pharmacology Middle Aged Prolactin Prolactin - metabolism Ritanserin Ritanserin - pharmacology Thyrotropin - metabolism Thyrotropin releasing hormone |
| title | Effects of methysergide and ritanserin on the prolactin and thyrotropin responses to TRH in depressed patients |
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