Tissue polypeptide antigen: a marker antigen differentiating cholangiolar tumors from other hepatic tumors
Twenty-two cases of primary hepatic tumors consisting of 11 hepatocellular carcinomas, 6 cholangiocarcinomas, 3 mixed hepatocellular and cholangiocellular carcinomas, and 2 biliary cystadenocarcinomas together with 8 cases of metastatic adenocarcinoma from various sites were studied by immunoperoxid...
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| Veröffentlicht in: | American journal of clinical pathology 1987-02, Vol.87 (2), p.168-173 |
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| container_end_page | 173 |
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| container_issue | 2 |
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| container_title | American journal of clinical pathology |
| container_volume | 87 |
| creator | PASTOLERO, G. C WAKABAYASHI, T OKA, T MORI, S |
| description | Twenty-two cases of primary hepatic tumors consisting of 11 hepatocellular carcinomas, 6 cholangiocarcinomas, 3 mixed hepatocellular and cholangiocellular carcinomas, and 2 biliary cystadenocarcinomas together with 8 cases of metastatic adenocarcinoma from various sites were studied by immunoperoxidase technic to demonstrate tissue polypeptide antigen. All of the tumors presumably derived from the epithelial lining of the bile duct, including cholangiocarcinoma, cholangiocarcinomatous portion of the mixed hepatocellular and cholangiocellular carcinoma, and biliary cystadenocarcinoma showed strong positive reaction. The hepatocellular carcinoma and the metastatic adenocarcinoma exhibited negative to weakly positive reactions. These results indicate that TPA can be of use in differentiating bile duct carcinomas from hepatocellular carcinoma and, to a lesser extent, from hepatic metastases of various adenocarcinomas. |
| doi_str_mv | 10.1093/ajcp/87.2.168 |
| format | Article |
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These results indicate that TPA can be of use in differentiating bile duct carcinomas from hepatocellular carcinoma and, to a lesser extent, from hepatic metastases of various adenocarcinomas.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1093/ajcp/87.2.168</identifier><identifier>PMID: 3028121</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>Adenocarcinoma - diagnosis ; Adenocarcinoma - immunology ; Adenoma, Bile Duct - diagnosis ; Adenoma, Bile Duct - immunology ; Antigens, Neoplasm - analysis ; Biological and medical sciences ; Carcinoma, Hepatocellular - diagnosis ; Carcinoma, Hepatocellular - immunology ; Diagnosis, Differential ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Immunoenzyme Techniques ; Liver Neoplasms - diagnosis ; Liver Neoplasms - immunology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Peptides - analysis ; Tissue Polypeptide Antigen ; Tumors</subject><ispartof>American journal of clinical pathology, 1987-02, Vol.87 (2), p.168-173</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8097234$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3028121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PASTOLERO, G. C</creatorcontrib><creatorcontrib>WAKABAYASHI, T</creatorcontrib><creatorcontrib>OKA, T</creatorcontrib><creatorcontrib>MORI, S</creatorcontrib><title>Tissue polypeptide antigen: a marker antigen differentiating cholangiolar tumors from other hepatic tumors</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>Twenty-two cases of primary hepatic tumors consisting of 11 hepatocellular carcinomas, 6 cholangiocarcinomas, 3 mixed hepatocellular and cholangiocellular carcinomas, and 2 biliary cystadenocarcinomas together with 8 cases of metastatic adenocarcinoma from various sites were studied by immunoperoxidase technic to demonstrate tissue polypeptide antigen. All of the tumors presumably derived from the epithelial lining of the bile duct, including cholangiocarcinoma, cholangiocarcinomatous portion of the mixed hepatocellular and cholangiocellular carcinoma, and biliary cystadenocarcinoma showed strong positive reaction. The hepatocellular carcinoma and the metastatic adenocarcinoma exhibited negative to weakly positive reactions. These results indicate that TPA can be of use in differentiating bile duct carcinomas from hepatocellular carcinoma and, to a lesser extent, from hepatic metastases of various adenocarcinomas.</description><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - immunology</subject><subject>Adenoma, Bile Duct - diagnosis</subject><subject>Adenoma, Bile Duct - immunology</subject><subject>Antigens, Neoplasm - analysis</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Carcinoma, Hepatocellular - immunology</subject><subject>Diagnosis, Differential</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - immunology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Peptides - analysis</subject><subject>Tissue Polypeptide Antigen</subject><subject>Tumors</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtPwzAMxyMEGmNw5IiUA-LWLa82KTc08ZImcRnnKU2dLaOPkLSHfXsiUfDBlv3_2bKN0C0lS0pKvtJH41dKLtmSFuoMzWkpeCYlY-doTghhWUklv0RXMR4JoUwRMUMzTpiijM7RcetiHAH7vjl58IOrAetucHvoHrHGrQ5fEP4quHbWQoCU6cF1e2wOfaO7vUs-4GFs-xCxDX2L--GQ2g7gE2cm5RpdWN1EuJniAn2-PG_Xb9nm4_V9_bTJPOP5kNm8IsJAXZUFqWuVTBrCRSULrXXOKwaMQ16XimoFQFkNImcFA8ss1YJTvkAPv3N96L9HiMOuddFAkzaFfow7KbkqCyESeDeBY9VCvfPBpXtPu-k5Sb-fdB2NbmzQnXHxH1OklIwL_gNvzHWn</recordid><startdate>19870201</startdate><enddate>19870201</enddate><creator>PASTOLERO, G. C</creator><creator>WAKABAYASHI, T</creator><creator>OKA, T</creator><creator>MORI, S</creator><general>American Society of Clinical Pathologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19870201</creationdate><title>Tissue polypeptide antigen: a marker antigen differentiating cholangiolar tumors from other hepatic tumors</title><author>PASTOLERO, G. C ; WAKABAYASHI, T ; OKA, T ; MORI, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-f5b04cedb960dd88887c034b76aaa53b2e23e5d981a8ee12de45262ef2f1a4313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - immunology</topic><topic>Adenoma, Bile Duct - diagnosis</topic><topic>Adenoma, Bile Duct - immunology</topic><topic>Antigens, Neoplasm - analysis</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular - diagnosis</topic><topic>Carcinoma, Hepatocellular - immunology</topic><topic>Diagnosis, Differential</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - immunology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Peptides - analysis</topic><topic>Tissue Polypeptide Antigen</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PASTOLERO, G. C</creatorcontrib><creatorcontrib>WAKABAYASHI, T</creatorcontrib><creatorcontrib>OKA, T</creatorcontrib><creatorcontrib>MORI, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PASTOLERO, G. C</au><au>WAKABAYASHI, T</au><au>OKA, T</au><au>MORI, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tissue polypeptide antigen: a marker antigen differentiating cholangiolar tumors from other hepatic tumors</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>1987-02-01</date><risdate>1987</risdate><volume>87</volume><issue>2</issue><spage>168</spage><epage>173</epage><pages>168-173</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>Twenty-two cases of primary hepatic tumors consisting of 11 hepatocellular carcinomas, 6 cholangiocarcinomas, 3 mixed hepatocellular and cholangiocellular carcinomas, and 2 biliary cystadenocarcinomas together with 8 cases of metastatic adenocarcinoma from various sites were studied by immunoperoxidase technic to demonstrate tissue polypeptide antigen. All of the tumors presumably derived from the epithelial lining of the bile duct, including cholangiocarcinoma, cholangiocarcinomatous portion of the mixed hepatocellular and cholangiocellular carcinoma, and biliary cystadenocarcinoma showed strong positive reaction. The hepatocellular carcinoma and the metastatic adenocarcinoma exhibited negative to weakly positive reactions. These results indicate that TPA can be of use in differentiating bile duct carcinomas from hepatocellular carcinoma and, to a lesser extent, from hepatic metastases of various adenocarcinomas.</abstract><cop>Chicago, IL</cop><pub>American Society of Clinical Pathologists</pub><pmid>3028121</pmid><doi>10.1093/ajcp/87.2.168</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9173 |
| ispartof | American journal of clinical pathology, 1987-02, Vol.87 (2), p.168-173 |
| issn | 0002-9173 1943-7722 |
| language | eng |
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| source | MEDLINE; Oxford Journals Archive |
| subjects | Adenocarcinoma - diagnosis Adenocarcinoma - immunology Adenoma, Bile Duct - diagnosis Adenoma, Bile Duct - immunology Antigens, Neoplasm - analysis Biological and medical sciences Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - immunology Diagnosis, Differential Gastroenterology. Liver. Pancreas. Abdomen Humans Immunoenzyme Techniques Liver Neoplasms - diagnosis Liver Neoplasms - immunology Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Peptides - analysis Tissue Polypeptide Antigen Tumors |
| title | Tissue polypeptide antigen: a marker antigen differentiating cholangiolar tumors from other hepatic tumors |
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