An Equivalent Site Mechanism for Na+ and K+ Binding to Sodium Pump and Control of the Conformational Change Reported by Fluorescein 5'-Isothiocyanate Modification

We have previously shown that two K+ must bind to cause the conformational change in Mg(2+)-dependent and Na(+)- and K(+)-stimulated ATPase reported by fluorescein 5'-isothiocyanate modification and that the ratio of the macroscopic K+ dissociation constants is 4 [Smirnova, I. N., & Faller,...

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Veröffentlicht in:	Biochemistry (Easton) 1995-07, Vol.34 (27), p.8657-8667
Hauptverfasser:	Smirnova, Irina N, Lin, Shwu-Hwa, Faller, Larry D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Fluorescein-5-isothiocyanate - chemistry Potassium - metabolism Protein Conformation Sodium - metabolism Sodium-Potassium-Exchanging ATPase - chemistry Sodium-Potassium-Exchanging ATPase - metabolism Swine
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