Hearing loss in Paget's disease of bone: The relationship between pure-tone thresholds and mineral density of the cochlear capsule

We have developed a unique method of quantitative computed tomography (QCT) that enables measurement of the density of the cochlear capsule in vivo. We performed pure-tone audiometry and QCT on 67 ears from 35 subjects with radiographically confirmed Paget's disease of the skull and on 40 ears...

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Veröffentlicht in:Hearing research 1995, Vol.83 (1), p.114-120
Hauptverfasser: Monsell, E.M., Cody, D.D., Bone, H.G., Divine, G.W., Windham, J.P., Jacobson, G.P., Newman, C.W., Patel, S.C.
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container_end_page 120
container_issue 1
container_start_page 114
container_title Hearing research
container_volume 83
creator Monsell, E.M.
Cody, D.D.
Bone, H.G.
Divine, G.W.
Windham, J.P.
Jacobson, G.P.
Newman, C.W.
Patel, S.C.
description We have developed a unique method of quantitative computed tomography (QCT) that enables measurement of the density of the cochlear capsule in vivo. We performed pure-tone audiometry and QCT on 67 ears from 35 subjects with radiographically confirmed Paget's disease of the skull and on 40 ears from twenty volunteer subjects. The Pearson product-moment correlation coefficients (age- and sex-adjusted) in the group affected by Paget's disease were −0.63 for left ears and −0.73 for right ears for high-frequency air conduction pure-tone thresholds (mean of 1, 2, and 4 kHz) versus cochlear capsule density. Correlation coefficients (age- and sex-adjusted) between cochlear capsule density and air-bone gap (mean at 0.5 and 1 kHz) for the affected group were −0.67 for left ears and −0.63 for right ears. All correlations between hearing thresholds and cochlear capsule density in pagetic subjects were significant at p < 0.001. The regression were consistent throughout the ranges of hearing level. There were no significant correlations between cochlear capsule mean density and hearing level in the volunteer subjects. These findings demonstrate the feasibility of precise and accurate density measurements in the temporal bone in vivo and support the use of the mean cochlear capsule density as a marker of disease effect. Alteration of cochlear capsule bone density may be related to the mechanisms of hearing loss in Paget's disease of bone.
doi_str_mv 10.1016/0378-5955(94)00196-W
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These findings demonstrate the feasibility of precise and accurate density measurements in the temporal bone in vivo and support the use of the mean cochlear capsule density as a marker of disease effect. 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These findings demonstrate the feasibility of precise and accurate density measurements in the temporal bone in vivo and support the use of the mean cochlear capsule density as a marker of disease effect. Alteration of cochlear capsule bone density may be related to the mechanisms of hearing loss in Paget's disease of bone.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>7607977</pmid><doi>10.1016/0378-5955(94)00196-W</doi><tpages>7</tpages></addata></record>
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source MEDLINE; Elsevier ScienceDirect Journals
subjects Adult
Aged
Aged, 80 and over
Analysis of Variance
Audiometry
Auditory Threshold - physiology
Behavioral audiometry
Biological and medical sciences
Bone Density - physiology
Bone mineral density
Cochlea - physiology
Cochlear capsule
Conductive hearing loss
Diseases of the osteoarticular system
Female
Hearing Loss, Conductive - etiology
Hearing Loss, Conductive - physiopathology
Humans
Image Processing, Computer-Assisted
Male
Medical sciences
Middle Aged
Osteitis Deformans - complications
Osteitis Deformans - physiopathology
Osteoporosis. Osteomalacia. Paget disease
Paget's disease
Risk Factors
Space life sciences
Temporal Bone - physiopathology
Tomography, X-Ray Computed
title Hearing loss in Paget's disease of bone: The relationship between pure-tone thresholds and mineral density of the cochlear capsule
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