Hearing loss in Paget's disease of bone: The relationship between pure-tone thresholds and mineral density of the cochlear capsule
We have developed a unique method of quantitative computed tomography (QCT) that enables measurement of the density of the cochlear capsule in vivo. We performed pure-tone audiometry and QCT on 67 ears from 35 subjects with radiographically confirmed Paget's disease of the skull and on 40 ears...
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Veröffentlicht in: | Hearing research 1995, Vol.83 (1), p.114-120 |
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creator | Monsell, E.M. Cody, D.D. Bone, H.G. Divine, G.W. Windham, J.P. Jacobson, G.P. Newman, C.W. Patel, S.C. |
description | We have developed a unique method of quantitative computed tomography (QCT) that enables measurement of the density of the cochlear capsule in vivo. We performed pure-tone audiometry and QCT on 67 ears from 35 subjects with radiographically confirmed Paget's disease of the skull and on 40 ears from twenty volunteer subjects. The Pearson product-moment correlation coefficients (age- and sex-adjusted) in the group affected by Paget's disease were −0.63 for left ears and −0.73 for right ears for high-frequency air conduction pure-tone thresholds (mean of 1, 2, and 4 kHz) versus cochlear capsule density. Correlation coefficients (age- and sex-adjusted) between cochlear capsule density and air-bone gap (mean at 0.5 and 1 kHz) for the affected group were −0.67 for left ears and −0.63 for right ears. All correlations between hearing thresholds and cochlear capsule density in pagetic subjects were significant at p < 0.001. The regression were consistent throughout the ranges of hearing level. There were no significant correlations between cochlear capsule mean density and hearing level in the volunteer subjects. These findings demonstrate the feasibility of precise and accurate density measurements in the temporal bone in vivo and support the use of the mean cochlear capsule density as a marker of disease effect. Alteration of cochlear capsule bone density may be related to the mechanisms of hearing loss in Paget's disease of bone. |
doi_str_mv | 10.1016/0378-5955(94)00196-W |
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We performed pure-tone audiometry and QCT on 67 ears from 35 subjects with radiographically confirmed Paget's disease of the skull and on 40 ears from twenty volunteer subjects. The Pearson product-moment correlation coefficients (age- and sex-adjusted) in the group affected by Paget's disease were −0.63 for left ears and −0.73 for right ears for high-frequency air conduction pure-tone thresholds (mean of 1, 2, and 4 kHz) versus cochlear capsule density. Correlation coefficients (age- and sex-adjusted) between cochlear capsule density and air-bone gap (mean at 0.5 and 1 kHz) for the affected group were −0.67 for left ears and −0.63 for right ears. All correlations between hearing thresholds and cochlear capsule density in pagetic subjects were significant at p < 0.001. The regression were consistent throughout the ranges of hearing level. There were no significant correlations between cochlear capsule mean density and hearing level in the volunteer subjects. These findings demonstrate the feasibility of precise and accurate density measurements in the temporal bone in vivo and support the use of the mean cochlear capsule density as a marker of disease effect. Alteration of cochlear capsule bone density may be related to the mechanisms of hearing loss in Paget's disease of bone.</description><identifier>ISSN: 0378-5955</identifier><identifier>EISSN: 1878-5891</identifier><identifier>DOI: 10.1016/0378-5955(94)00196-W</identifier><identifier>PMID: 7607977</identifier><identifier>CODEN: HERED3</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; Audiometry ; Auditory Threshold - physiology ; Behavioral audiometry ; Biological and medical sciences ; Bone Density - physiology ; Bone mineral density ; Cochlea - physiology ; Cochlear capsule ; Conductive hearing loss ; Diseases of the osteoarticular system ; Female ; Hearing Loss, Conductive - etiology ; Hearing Loss, Conductive - physiopathology ; Humans ; Image Processing, Computer-Assisted ; Male ; Medical sciences ; Middle Aged ; Osteitis Deformans - complications ; Osteitis Deformans - physiopathology ; Osteoporosis. Osteomalacia. Paget disease ; Paget's disease ; Risk Factors ; Space life sciences ; Temporal Bone - physiopathology ; Tomography, X-Ray Computed</subject><ispartof>Hearing research, 1995, Vol.83 (1), p.114-120</ispartof><rights>1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-5a0a780e83626c8531510bae1c976aba7242cc1db8beadf663bfa52133ed166e3</citedby><cites>FETCH-LOGICAL-c512t-5a0a780e83626c8531510bae1c976aba7242cc1db8beadf663bfa52133ed166e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0378-5955(94)00196-W$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,777,781,786,787,3537,4010,4036,4037,23911,23912,25121,27904,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3485176$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7607977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Monsell, E.M.</creatorcontrib><creatorcontrib>Cody, D.D.</creatorcontrib><creatorcontrib>Bone, H.G.</creatorcontrib><creatorcontrib>Divine, G.W.</creatorcontrib><creatorcontrib>Windham, J.P.</creatorcontrib><creatorcontrib>Jacobson, G.P.</creatorcontrib><creatorcontrib>Newman, C.W.</creatorcontrib><creatorcontrib>Patel, S.C.</creatorcontrib><title>Hearing loss in Paget's disease of bone: The relationship between pure-tone thresholds and mineral density of the cochlear capsule</title><title>Hearing research</title><addtitle>Hear Res</addtitle><description>We have developed a unique method of quantitative computed tomography (QCT) that enables measurement of the density of the cochlear capsule in vivo. We performed pure-tone audiometry and QCT on 67 ears from 35 subjects with radiographically confirmed Paget's disease of the skull and on 40 ears from twenty volunteer subjects. The Pearson product-moment correlation coefficients (age- and sex-adjusted) in the group affected by Paget's disease were −0.63 for left ears and −0.73 for right ears for high-frequency air conduction pure-tone thresholds (mean of 1, 2, and 4 kHz) versus cochlear capsule density. Correlation coefficients (age- and sex-adjusted) between cochlear capsule density and air-bone gap (mean at 0.5 and 1 kHz) for the affected group were −0.67 for left ears and −0.63 for right ears. All correlations between hearing thresholds and cochlear capsule density in pagetic subjects were significant at p < 0.001. The regression were consistent throughout the ranges of hearing level. There were no significant correlations between cochlear capsule mean density and hearing level in the volunteer subjects. These findings demonstrate the feasibility of precise and accurate density measurements in the temporal bone in vivo and support the use of the mean cochlear capsule density as a marker of disease effect. Alteration of cochlear capsule bone density may be related to the mechanisms of hearing loss in Paget's disease of bone.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis of Variance</subject><subject>Audiometry</subject><subject>Auditory Threshold - physiology</subject><subject>Behavioral audiometry</subject><subject>Biological and medical sciences</subject><subject>Bone Density - physiology</subject><subject>Bone mineral density</subject><subject>Cochlea - physiology</subject><subject>Cochlear capsule</subject><subject>Conductive hearing loss</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Hearing Loss, Conductive - etiology</subject><subject>Hearing Loss, Conductive - physiopathology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Osteitis Deformans - complications</subject><subject>Osteitis Deformans - physiopathology</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Paget's disease</subject><subject>Risk Factors</subject><subject>Space life sciences</subject><subject>Temporal Bone - physiopathology</subject><subject>Tomography, X-Ray Computed</subject><issn>0378-5955</issn><issn>1878-5891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EKtvCPwDJB0ThELDj-CMckFAFFKkSHIp6tBx70hh5na3tgHrll-Owqz3CaSTPM-9Y8yD0jJI3lFDxljCpGt5z_qrvXhNCe9HcPEAbqtZn1dOHaHNEHqPTnH9UiLOuPUEnUhDZS7lBvy_BJB9vcZhzxj7ib-YWynnGzmcwGfA84mGO8A5fT4ATBFP8HPPkd3iA8gsg4t2SoCmVwWVKkKc5uIxNdHjrIyQTsIOYfblfo0oNsbOdQt2KrdnlJcAT9Gg0IcPTQz1D3z99vL64bK6-fv5y8eGqsZy2peGGGKkIKCZaYRVnlFMyGKC2l8IMRrZday11gxrAuFEINoyGt5QxcFQIYGfo5T53l-a7BXLRW58thGAizEvWUjLV9R39L0iFooQzVsFuD9pUr5dg1Lvktybda0r06kivAvQqQPed_utI39Sx54f8ZdiCOw4dpNT-i0PfZGvCmEy0Ph8x1ilOpajY-z0G9Wg_PSSdrYdowfkEtmg3-3__4w_emq8o</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Monsell, E.M.</creator><creator>Cody, D.D.</creator><creator>Bone, H.G.</creator><creator>Divine, G.W.</creator><creator>Windham, J.P.</creator><creator>Jacobson, G.P.</creator><creator>Newman, C.W.</creator><creator>Patel, S.C.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>1995</creationdate><title>Hearing loss in Paget's disease of bone: The relationship between pure-tone thresholds and mineral density of the cochlear capsule</title><author>Monsell, E.M. ; Cody, D.D. ; Bone, H.G. ; Divine, G.W. ; Windham, J.P. ; Jacobson, G.P. ; Newman, C.W. ; Patel, S.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-5a0a780e83626c8531510bae1c976aba7242cc1db8beadf663bfa52133ed166e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis of Variance</topic><topic>Audiometry</topic><topic>Auditory Threshold - physiology</topic><topic>Behavioral audiometry</topic><topic>Biological and medical sciences</topic><topic>Bone Density - physiology</topic><topic>Bone mineral density</topic><topic>Cochlea - physiology</topic><topic>Cochlear capsule</topic><topic>Conductive hearing loss</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Hearing Loss, Conductive - etiology</topic><topic>Hearing Loss, Conductive - physiopathology</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Osteitis Deformans - complications</topic><topic>Osteitis Deformans - physiopathology</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Paget's disease</topic><topic>Risk Factors</topic><topic>Space life sciences</topic><topic>Temporal Bone - physiopathology</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Monsell, E.M.</creatorcontrib><creatorcontrib>Cody, D.D.</creatorcontrib><creatorcontrib>Bone, H.G.</creatorcontrib><creatorcontrib>Divine, G.W.</creatorcontrib><creatorcontrib>Windham, J.P.</creatorcontrib><creatorcontrib>Jacobson, G.P.</creatorcontrib><creatorcontrib>Newman, C.W.</creatorcontrib><creatorcontrib>Patel, S.C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Hearing research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Monsell, E.M.</au><au>Cody, D.D.</au><au>Bone, H.G.</au><au>Divine, G.W.</au><au>Windham, J.P.</au><au>Jacobson, G.P.</au><au>Newman, C.W.</au><au>Patel, S.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hearing loss in Paget's disease of bone: The relationship between pure-tone thresholds and mineral density of the cochlear capsule</atitle><jtitle>Hearing research</jtitle><addtitle>Hear Res</addtitle><date>1995</date><risdate>1995</risdate><volume>83</volume><issue>1</issue><spage>114</spage><epage>120</epage><pages>114-120</pages><issn>0378-5955</issn><eissn>1878-5891</eissn><coden>HERED3</coden><abstract>We have developed a unique method of quantitative computed tomography (QCT) that enables measurement of the density of the cochlear capsule in vivo. We performed pure-tone audiometry and QCT on 67 ears from 35 subjects with radiographically confirmed Paget's disease of the skull and on 40 ears from twenty volunteer subjects. The Pearson product-moment correlation coefficients (age- and sex-adjusted) in the group affected by Paget's disease were −0.63 for left ears and −0.73 for right ears for high-frequency air conduction pure-tone thresholds (mean of 1, 2, and 4 kHz) versus cochlear capsule density. Correlation coefficients (age- and sex-adjusted) between cochlear capsule density and air-bone gap (mean at 0.5 and 1 kHz) for the affected group were −0.67 for left ears and −0.63 for right ears. All correlations between hearing thresholds and cochlear capsule density in pagetic subjects were significant at p < 0.001. The regression were consistent throughout the ranges of hearing level. There were no significant correlations between cochlear capsule mean density and hearing level in the volunteer subjects. These findings demonstrate the feasibility of precise and accurate density measurements in the temporal bone in vivo and support the use of the mean cochlear capsule density as a marker of disease effect. Alteration of cochlear capsule bone density may be related to the mechanisms of hearing loss in Paget's disease of bone.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>7607977</pmid><doi>10.1016/0378-5955(94)00196-W</doi><tpages>7</tpages></addata></record> |
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subjects | Adult Aged Aged, 80 and over Analysis of Variance Audiometry Auditory Threshold - physiology Behavioral audiometry Biological and medical sciences Bone Density - physiology Bone mineral density Cochlea - physiology Cochlear capsule Conductive hearing loss Diseases of the osteoarticular system Female Hearing Loss, Conductive - etiology Hearing Loss, Conductive - physiopathology Humans Image Processing, Computer-Assisted Male Medical sciences Middle Aged Osteitis Deformans - complications Osteitis Deformans - physiopathology Osteoporosis. Osteomalacia. Paget disease Paget's disease Risk Factors Space life sciences Temporal Bone - physiopathology Tomography, X-Ray Computed |
title | Hearing loss in Paget's disease of bone: The relationship between pure-tone thresholds and mineral density of the cochlear capsule |
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