A nodal-related gene defines a physical and functional domain within the Spemann organizer
A functional screen for gene products that rescue dorsal development in ventralized Xenopus embryos has yielded Xenopus nodal-related 3 ( Xnr3), a diverged member of the TGFβ superfamily. Xnr3 is specifically expressed in the Spemann organizer and is only expressed in the epithelial layer of the org...
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| Veröffentlicht in: | Cell 1995-07, Vol.82 (1), p.37-46 |
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| creator | Smith, William C. McKendry, Roslyn Ribisi, Stephen Harland, Richard M. |
| description | A functional screen for gene products that rescue dorsal development in ventralized Xenopus embryos has yielded Xenopus
nodal-related 3 (
Xnr3), a diverged member of the TGFβ superfamily.
Xnr3 is specifically expressed in the Spemann organizer and is only expressed in the epithelial layer of the organizer immediately preceding and extending through gastrulation. Like
noggin,
Xnr3 can induce muscle in ventral mesoderm explants, consistent with a role in patterning the gastrula. In other ways, the activity of
Xnr3 is different from
noggin. Embryos receiving injections of
Xnr3, particularly in the animal pole, send out tube-like extensions of tissue from the site of injection. These protrusions usually contain no axial mesoderm and only occasionally are positive for neural markers. It has previously been proposed that the epithelial layer of the organizer initiates and coordinates the morphogenetic movements at gastrulation. The protrusions observed may reflect an activity of
Xnr3 in promoting morphogenesis. |
| doi_str_mv | 10.1016/0092-8674(95)90050-0 |
| format | Article |
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nodal-related 3 (
Xnr3), a diverged member of the TGFβ superfamily.
Xnr3 is specifically expressed in the Spemann organizer and is only expressed in the epithelial layer of the organizer immediately preceding and extending through gastrulation. Like
noggin,
Xnr3 can induce muscle in ventral mesoderm explants, consistent with a role in patterning the gastrula. In other ways, the activity of
Xnr3 is different from
noggin. Embryos receiving injections of
Xnr3, particularly in the animal pole, send out tube-like extensions of tissue from the site of injection. These protrusions usually contain no axial mesoderm and only occasionally are positive for neural markers. It has previously been proposed that the epithelial layer of the organizer initiates and coordinates the morphogenetic movements at gastrulation. The protrusions observed may reflect an activity of
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nodal-related 3 (
Xnr3), a diverged member of the TGFβ superfamily.
Xnr3 is specifically expressed in the Spemann organizer and is only expressed in the epithelial layer of the organizer immediately preceding and extending through gastrulation. Like
noggin,
Xnr3 can induce muscle in ventral mesoderm explants, consistent with a role in patterning the gastrula. In other ways, the activity of
Xnr3 is different from
noggin. Embryos receiving injections of
Xnr3, particularly in the animal pole, send out tube-like extensions of tissue from the site of injection. These protrusions usually contain no axial mesoderm and only occasionally are positive for neural markers. It has previously been proposed that the epithelial layer of the organizer initiates and coordinates the morphogenetic movements at gastrulation. The protrusions observed may reflect an activity of
Xnr3 in promoting morphogenesis.</description><subject>Actins - biosynthesis</subject><subject>Activins</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Blastocyst - chemistry</subject><subject>Carrier Proteins</subject><subject>Cell Differentiation</subject><subject>Cloning, Molecular</subject><subject>Epithelium</subject><subject>Freshwater</subject><subject>Gastrula - chemistry</subject><subject>Gastrula - physiology</subject><subject>Gene Expression Regulation, Developmental - genetics</subject><subject>Inhibins - physiology</subject><subject>Mesoderm</subject><subject>Molecular Sequence Data</subject><subject>Morphogenesis</subject><subject>Proteins - physiology</subject><subject>Receptors, Transforming Growth Factor beta - genetics</subject><subject>Receptors, Transforming Growth Factor beta - physiology</subject><subject>RNA, Messenger - analysis</subject><subject>Sequence Alignment</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology, Amino Acid</subject><subject>Transforming Growth Factor beta</subject><subject>Xenopus</subject><subject>Xenopus Proteins</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LHDEYx0Np0dX6DVrIqdTD6JPN-6Ugom1B6KF66SVkkmfclJnMmsy22E_vrLt4rKc_D_-XB36EfGBwxoCpcwC7bIzS4rOVpxZAQgNvyIKB1Y1gevmWLF4ih-So1t8AYKSUB-RAK1Da8AX5dUHzGH3fFOz9hJHeY0YasUsZK_V0vXqsKfie-hxpt8lhSmOezzgOPmX6N02rWaYV0p9rHHzOdCz3Pqd_WN6Td53vK57s9ZjcXV_dXn5rbn58_X55cdMEwcXUBEQmW4Y6cmlRdNYIbXVsJQiJ0rOoBbedjKHVXvtOcQTDJSgvW2mAR35MPu1212V82GCd3JBqwL73GcdNdVpzw4VavhpkyiylUTAHxS4Yylhrwc6tSxp8eXQM3Ja924J1W7DOSvfM3m1rH_f7m3bA-FLaw579LzsfZxp_EhZXQ8IcMKaCYXJxTP9_8AQ6lpMK</recordid><startdate>19950714</startdate><enddate>19950714</enddate><creator>Smith, William C.</creator><creator>McKendry, Roslyn</creator><creator>Ribisi, Stephen</creator><creator>Harland, Richard M.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>L.G</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19950714</creationdate><title>A nodal-related gene defines a physical and functional domain within the Spemann organizer</title><author>Smith, William C. ; McKendry, Roslyn ; Ribisi, Stephen ; Harland, Richard M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-cee15b1e7d359e4f984797db5045e5a1d7439f5dcb7a7af63e083506a5b5803d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Actins - biosynthesis</topic><topic>Activins</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Blastocyst - chemistry</topic><topic>Carrier Proteins</topic><topic>Cell Differentiation</topic><topic>Cloning, Molecular</topic><topic>Epithelium</topic><topic>Freshwater</topic><topic>Gastrula - chemistry</topic><topic>Gastrula - physiology</topic><topic>Gene Expression Regulation, Developmental - genetics</topic><topic>Inhibins - physiology</topic><topic>Mesoderm</topic><topic>Molecular Sequence Data</topic><topic>Morphogenesis</topic><topic>Proteins - physiology</topic><topic>Receptors, Transforming Growth Factor beta - genetics</topic><topic>Receptors, Transforming Growth Factor beta - physiology</topic><topic>RNA, Messenger - analysis</topic><topic>Sequence Alignment</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology, Amino Acid</topic><topic>Transforming Growth Factor beta</topic><topic>Xenopus</topic><topic>Xenopus Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, William C.</creatorcontrib><creatorcontrib>McKendry, Roslyn</creatorcontrib><creatorcontrib>Ribisi, Stephen</creatorcontrib><creatorcontrib>Harland, Richard M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, William C.</au><au>McKendry, Roslyn</au><au>Ribisi, Stephen</au><au>Harland, Richard M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A nodal-related gene defines a physical and functional domain within the Spemann organizer</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>1995-07-14</date><risdate>1995</risdate><volume>82</volume><issue>1</issue><spage>37</spage><epage>46</epage><pages>37-46</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>A functional screen for gene products that rescue dorsal development in ventralized Xenopus embryos has yielded Xenopus
nodal-related 3 (
Xnr3), a diverged member of the TGFβ superfamily.
Xnr3 is specifically expressed in the Spemann organizer and is only expressed in the epithelial layer of the organizer immediately preceding and extending through gastrulation. Like
noggin,
Xnr3 can induce muscle in ventral mesoderm explants, consistent with a role in patterning the gastrula. In other ways, the activity of
Xnr3 is different from
noggin. Embryos receiving injections of
Xnr3, particularly in the animal pole, send out tube-like extensions of tissue from the site of injection. These protrusions usually contain no axial mesoderm and only occasionally are positive for neural markers. It has previously been proposed that the epithelial layer of the organizer initiates and coordinates the morphogenetic movements at gastrulation. The protrusions observed may reflect an activity of
Xnr3 in promoting morphogenesis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7606783</pmid><doi>10.1016/0092-8674(95)90050-0</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0092-8674 1097-4172 |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Actins - biosynthesis Activins Amino Acid Sequence Animals Blastocyst - chemistry Carrier Proteins Cell Differentiation Cloning, Molecular Epithelium Freshwater Gastrula - chemistry Gastrula - physiology Gene Expression Regulation, Developmental - genetics Inhibins - physiology Mesoderm Molecular Sequence Data Morphogenesis Proteins - physiology Receptors, Transforming Growth Factor beta - genetics Receptors, Transforming Growth Factor beta - physiology RNA, Messenger - analysis Sequence Alignment Sequence Analysis, DNA Sequence Homology, Amino Acid Transforming Growth Factor beta Xenopus Xenopus Proteins |
| title | A nodal-related gene defines a physical and functional domain within the Spemann organizer |
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