Murine Model of Intracerebral Toxoplasmosis
We established a murine model of toxoplasmic encephalitis by using intracerebral inoculation with Toxoplasma gondii tachyzoites. Normal mice survived, but immunosuppressed mice died from progressive disease. In normal mice, necrosis developed at the site of inoculation, surrounded by areas with inte...
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| Veröffentlicht in: | The Journal of infectious diseases 1987-03, Vol.155 (3), p.550-557 |
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| container_title | The Journal of infectious diseases |
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| creator | Hofflin, Jesse M. Conley, Frances K. Remington, Jack S. |
| description | We established a murine model of toxoplasmic encephalitis by using intracerebral inoculation with Toxoplasma gondii tachyzoites. Normal mice survived, but immunosuppressed mice died from progressive disease. In normal mice, necrosis developed at the site of inoculation, surrounded by areas with intense mononuclear inflammation and cyst formation; tachyzoites were not detectable after two weeks. Immunosuppressed mice had evenlarger areas of tissue destruction, and tachyzoites were always detectable. Brains from cortisone-treated mice had numerous tachyzoites, but scant inflammation. Brains from cyclophosphamide-treated mice revealed cysts and a variable degree of inflammation. Compared with brains from controls, brains from cyclosporine-treated mice revealed attenuated inflammation; however, there were fewer tachyzoites and less tissue destruction than in the brains from cortisone-treated mice. The spectrum of histological findings observed in the model is similar to that observed in brains from humans with toxoplasmic encephalitis. |
| doi_str_mv | 10.1093/infdis/155.3.550 |
| format | Article |
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Normal mice survived, but immunosuppressed mice died from progressive disease. In normal mice, necrosis developed at the site of inoculation, surrounded by areas with intense mononuclear inflammation and cyst formation; tachyzoites were not detectable after two weeks. Immunosuppressed mice had evenlarger areas of tissue destruction, and tachyzoites were always detectable. Brains from cortisone-treated mice had numerous tachyzoites, but scant inflammation. Brains from cyclophosphamide-treated mice revealed cysts and a variable degree of inflammation. Compared with brains from controls, brains from cyclosporine-treated mice revealed attenuated inflammation; however, there were fewer tachyzoites and less tissue destruction than in the brains from cortisone-treated mice. 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Normal mice survived, but immunosuppressed mice died from progressive disease. In normal mice, necrosis developed at the site of inoculation, surrounded by areas with intense mononuclear inflammation and cyst formation; tachyzoites were not detectable after two weeks. Immunosuppressed mice had evenlarger areas of tissue destruction, and tachyzoites were always detectable. Brains from cortisone-treated mice had numerous tachyzoites, but scant inflammation. Brains from cyclophosphamide-treated mice revealed cysts and a variable degree of inflammation. Compared with brains from controls, brains from cyclosporine-treated mice revealed attenuated inflammation; however, there were fewer tachyzoites and less tissue destruction than in the brains from cortisone-treated mice. The spectrum of histological findings observed in the model is similar to that observed in brains from humans with toxoplasmic encephalitis.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - parasitology</subject><subject>Brain - pathology</subject><subject>Cyclosporins</subject><subject>Cysts</subject><subject>Disease Models, Animal</subject><subject>Encephalitis</subject><subject>Encephalitis - immunology</subject><subject>Encephalitis - parasitology</subject><subject>Encephalitis - pathology</subject><subject>Experimental protozoal diseases and models</subject><subject>Female</subject><subject>Histology</subject><subject>Immune Tolerance</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Inflammation</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Original Articles</subject><subject>Parasitic diseases</subject><subject>Protozoal diseases</subject><subject>Tachyzoites</subject><subject>Toxoplasma - isolation & purification</subject><subject>Toxoplasmosis</subject><subject>Toxoplasmosis, Animal - immunology</subject><subject>Toxoplasmosis, Animal - parasitology</subject><subject>Toxoplasmosis, Animal - pathology</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1LAzEQhoMoWqt3L0IP4kW2nWx2kt2jFLUFi4gVxEvIZhPYut3UZAv13xtp_bh5GALzvvMcnhByRmFIoWCjurVVHUYUcciGiLBHehSZSDinbJ_0ANI0oXlRHJHjEBYAkDEuDskhywGFED1yNVv7ujWDmatMM3B2MG07r7TxpvSqGczdxq0aFZYu1OGEHFjVBHO6e_vk-fZmPp4k9w930_H1faIzmnWJ1YUpVRyuLdcVIjLDcpZbUNRkWHHAuDW6TBFAVZhriyIvlTKal2lVsj653HJX3r2vTejksg7aNI1qjVsHKQTLU5Gl_xZpJjBntIhF2Ba1dyF4Y-XK10vlPyQF-SVSbkXKKFIyGUXGk_Mde10uTfVzsDMX84tdroJWjfWq1RHwXRPI4z_8wSxC5_wvBSgg8C9Mss3r0JnNT678m4ypQDl5eZWYPfHJ7exRztknTVSVqA</recordid><startdate>19870301</startdate><enddate>19870301</enddate><creator>Hofflin, Jesse M.</creator><creator>Conley, Frances K.</creator><creator>Remington, Jack S.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>19870301</creationdate><title>Murine Model of Intracerebral Toxoplasmosis</title><author>Hofflin, Jesse M. ; Conley, Frances K. ; Remington, Jack S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-fc9eba9eb6cf6cd5553e3838f0a1e45d605cd5ecb2500ad58cf578baaec6b2db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - parasitology</topic><topic>Brain - pathology</topic><topic>Cyclosporins</topic><topic>Cysts</topic><topic>Disease Models, Animal</topic><topic>Encephalitis</topic><topic>Encephalitis - immunology</topic><topic>Encephalitis - parasitology</topic><topic>Encephalitis - pathology</topic><topic>Experimental protozoal diseases and models</topic><topic>Female</topic><topic>Histology</topic><topic>Immune Tolerance</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Inflammation</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Original Articles</topic><topic>Parasitic diseases</topic><topic>Protozoal diseases</topic><topic>Tachyzoites</topic><topic>Toxoplasma - isolation & purification</topic><topic>Toxoplasmosis</topic><topic>Toxoplasmosis, Animal - immunology</topic><topic>Toxoplasmosis, Animal - parasitology</topic><topic>Toxoplasmosis, Animal - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hofflin, Jesse M.</creatorcontrib><creatorcontrib>Conley, Frances K.</creatorcontrib><creatorcontrib>Remington, Jack S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hofflin, Jesse M.</au><au>Conley, Frances K.</au><au>Remington, Jack S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Murine Model of Intracerebral Toxoplasmosis</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1987-03-01</date><risdate>1987</risdate><volume>155</volume><issue>3</issue><spage>550</spage><epage>557</epage><pages>550-557</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>We established a murine model of toxoplasmic encephalitis by using intracerebral inoculation with Toxoplasma gondii tachyzoites. Normal mice survived, but immunosuppressed mice died from progressive disease. In normal mice, necrosis developed at the site of inoculation, surrounded by areas with intense mononuclear inflammation and cyst formation; tachyzoites were not detectable after two weeks. Immunosuppressed mice had evenlarger areas of tissue destruction, and tachyzoites were always detectable. Brains from cortisone-treated mice had numerous tachyzoites, but scant inflammation. Brains from cyclophosphamide-treated mice revealed cysts and a variable degree of inflammation. Compared with brains from controls, brains from cyclosporine-treated mice revealed attenuated inflammation; however, there were fewer tachyzoites and less tissue destruction than in the brains from cortisone-treated mice. The spectrum of histological findings observed in the model is similar to that observed in brains from humans with toxoplasmic encephalitis.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>3805777</pmid><doi>10.1093/infdis/155.3.550</doi><tpages>8</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1987-03, Vol.155 (3), p.550-557 |
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| source | MEDLINE; Jstor Complete Legacy |
| subjects | Animals Biological and medical sciences Brain - parasitology Brain - pathology Cyclosporins Cysts Disease Models, Animal Encephalitis Encephalitis - immunology Encephalitis - parasitology Encephalitis - pathology Experimental protozoal diseases and models Female Histology Immune Tolerance Infections Infectious diseases Inflammation Medical sciences Mice Original Articles Parasitic diseases Protozoal diseases Tachyzoites Toxoplasma - isolation & purification Toxoplasmosis Toxoplasmosis, Animal - immunology Toxoplasmosis, Animal - parasitology Toxoplasmosis, Animal - pathology |
| title | Murine Model of Intracerebral Toxoplasmosis |
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