Genetic analysis of human B cell hybridomas expressing a cross-reactive idiotype

We have examined the genetic basis for the expression of a human cross-reactive idiotype (CRI) commonly found on monoclonal IgM rheumatoid factors. The CRI was identified with a monoclonal antibody (17.109) and has been localized previously to the kappa-variable region. By using the human lymphoblas...

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Veröffentlicht in:	The Journal of immunology (1950) 1987-02, Vol.138 (3), p.940-944
Hauptverfasser:	Goldfien, RD, Chen, PJ, Kipps, TJ, Starkebaum, G, Heitzmann, JG, Radoux, V, Fong, S, Carson, DA
Format:	Artikel
Sprache:	eng
Schlagworte:	B-Lymphocytes - immunology Cross Reactions DNA - analysis Humans Hybridomas - immunology Immunoglobulin Idiotypes - genetics Immunoglobulin kappa-Chains - genetics Immunoglobulin Variable Region - genetics Nucleic Acid Hybridization Recombination, Genetic RNA - analysis
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